Dr. Perlmutter's Brain Maker Q&A on Periscope

This content was created by David Perlmutter. This content was uploaded by David Perlmutter. This is a YouTube Periscope Q&A titled "Dr. Perlmutter's Brain Maker Q&A on Periscope" (recorded May 13, 2015) featuring Dr. David Perlmutter answering questions from moderators and an audience about his new book Brain Maker. The session is a live, expert-led Q&A/conversation with multiple speakers (moderators labeled SPEAKER B and SPEAKER C and audience callers) covering the gut–brain connection and practical topics such as turmeric alternatives, coffee/tea/red wine benefits, fecal microbial transplant, probiotics and prebiotics, diet (gluten/sugar/fats), ADHD in children, ketogenic/MCT/coconut oil, supplements (cod liver oil, vitamin D, DHA), exercise, kombucha/fermented foods, and care for people with dementia. Metadata: YouTube content, thumbnail available, created_time 2015-05-13, title as above.
Chapters
Hi everybody, I'm Dr. David Perlmutter, and please feel free to go ahead and dial in your questions, type them in, and we've already got a bunch of questions. They're going to be read to me off camera, and let's get started.
Alright, Dr. Perlmutter, your first question: I've had adverse effects from turmeric. Is there any alternative that you would suggest?
So the real reason I like turmeric so much is because its role in activating certain genes that are anti-inflammatory. As well as genes that help turn on the production of antioxidants and detoxification. So, it's a super cool herb, spice, and the literature that's talked about turmeric really goes back to 3,000 years ago to the Vedic texts. But that said, there are a certain number of people who just can't use turmeric for one reason or another. Some people get rashes and some people can sneeze and turn— the skin turns red. So, what I would say is we still want to activate that same pathway that's protective, reducing inflammation, bumping up antioxidant function, and the pathway is called the NRF2 pathway. And how you can activate the NRF2 pathway is, number one, you're going to love this, drink coffee. Yes, coffee activates the very same pathway that turmeric does. Resveratrol is a Very popular nutritional supplement at the health food store, and truly you can also activate the same pathway by getting aerobic exercise. So, there are lots of cool things that you can do well beyond turmeric to reap its benefits and really act very much in the same way, but you're not alone, whoever asked that question.
You have some more folks asking about coffee and red wine. Do you want to talk a little bit more about their benefits?
I knew I would gain friends with the coffee and the red wine. So, both coffee and red wine are really great things to consume in, of course, moderation. I mean, a glass or 2 of red wine each day for men and maybe no more than 1 glass a day for women. The reason being that coffee is low in sugar, so I'm fine with that, but it is very rich in what are called polyphenols, and polyphenols are chemicals that are in and of themselves antioxidants. And also act as nutrients for the good levels, the good type of bacteria that live within the microbiome, that live within your gut. So I'm all over it, and this may well explain the so-called French paradox where the French people are thought to eat food that is not ideal, but you know, now that I think about it, the reason we talked about the French paradox over the years is because the French had such a high-fat diet and we all thought that was a horrible thing. Well, now there is no French paradox because it turns out they were eating the right diet all along. They eat less carbs than we do here in America. The other part of that question I think dealt with coffee. There are some direct effects of coffee in terms of its polyphenol content and also its caffeine content, both of which are now associated with a 20% risk reduction from the European literature Rather, risk for dementia reduced by 20% in a 4-year study in people having from 3 to 5 cups of coffee each day. There's also a reduction in risk of progression of gallbladder issues, and there has been some discussion of perhaps a slightly lowered risk of diabetes mellitus type 2. So, I'm all for it. The downsides of coffee, of course, can be up— enhancing your blood pressure, increasing your blood pressure. heart irregularities in terms of heartbeat and also even raising your heart rate. There's been some discussion of some delivery issues of women having babies having issues if they were heavy caffeine consumers.
So now as you're talking about coffee, we had a lot of people ask, what about green tea? Are the benefits similar?
So green tea is very reasonable as well, and as a matter of fact, There are things in green tea like the catechins that act as anti-inflammatories, and also we can reap the benefits of green tea even if it's decaffeinated. And in fact, there are some upsides of coffee even that has been decaffeinated, to get back to our previous discussion. So, I think green tea is a very healthful beverage to consume.
All right, excellent. Another question we've seen, we've had a couple people actually ask about fecal transplant already and they wanna know what they can do to help bring— what can we as patients do to help to bring about a revolution towards this sort of treatment in the United States?
Well, it's a great question. And the reason I included those 2 cases of fecal transplant in Brain Maker was to really drive home the point as to what is the role of the microbiome? And what happens when it goes bad and what happens when it is reset using fecal microbial transplant. So, as a general statement, I don't do the procedure, but many of my patients have undergone it, either doing it themselves or going to facilities that will do that. I mean, there are places around the country now that will do that. And we know that in more than 150 hospitals in America right now, fecal microbial transplant is being performed. As a treatment for Clostridium difficile. My hope is that Brain Maker is going to break the ice and really allow people to recognize that this is a very, very powerful therapeutic modality, a powerful technique, and understand that we've got to get past the ick factor and recognize how powerful this is. I certainly feel there's profound importance in terms of making sure that donors for fecal microbial transplant are adequately screened, and we know that at least the process that the hospitals in America are using is one that includes a vigorous screening program. I believe that in the future, as in just maybe the next 3 to 5 years, we're going to see widespread application of this. process. We now know that University of Arizona has just completed recruiting autistic patients to treat them with fecal microbial transplant because we do know that, for example, the microbiome of the autistic child is very much disrupted. And I reported a case in our book, Brain Maker, of a child having significant recovery, gaining back the ability to speak, Gaining back the ability to socially interact by undergoing fecal transplant. And if you visit drperlmutter.com, drperlmutter.com, our website, we'll tweet that in. We actually have video of Jason after he's received this procedure with commentary. So those are wonderful questions. And I know that now that BrainMaker is out as of today, This is going to pave the way for a huge amount of discussion on this topic.
Excellent. And as that was coming, we had one question come in to see if you had any suggestions for folks with chronic migraines.
So the question is about chronic migraine headaches, and I'd say step 1 is gluten-free. Who knew? Dating back to the days of Grain Brain, 18 months ago or whenever that was, that is one of our best ways of helping these individuals with This inflammatory disorder. But beyond that, understand that inflammation comes from the gut. So I would say in addition to gluten-free, target the gut, target the gut bacteria with aggressive probiotics, eating probiotic food, prebiotic food, and undergo food sensitivity testing. Find out beyond gluten what you need to eliminate.
All right, excellent. While you're taking a drink, I'll stay back on the subject of coffee for a moment.
Kombucha, by the way, with a bite.
Folks just asking specifically about coffee, if you feel there are any concerns for folks who— it might be harmful for autoimmune patients or folks who have epilepsy.
I would— again, I'm not your doctor, though I play one on Twitter. I would say that it is something to discuss with your treating physician because we're getting into medical treatment here. In my practice, I've not had any real issues. of concern in dealing with my patients with seizures in terms of caffeine consumption, obviously within moderation. And with respect to autoimmune disease, again, we're healing the gut, we're trying to reduce the permeability or the leaky gut, and I think coffee can— is likely going to be helping us in that regard.
Excellent. We just had someone ask about probiotics. Are there any side effects with Is there anything we should be concerned about?
There are people who don't tolerate all kinds of things, and I think a lot of times when people say they don't tolerate a probiotic that they may be taking, I'd say you've got to be careful of additives and fillers. In my experience, that's the biggest issue in terms of not tolerating the probiotic. So, I would try to get a supplement that doesn't really have any additives and fillers. Because rather than the bacteria themselves, I think that's what people tend to have problems with.
Somebody said that they get brain fog with coffee.
Well, again, we're all different and I'm providing the broad strokes here in terms of what makes sense, what does current leading-edge peer-reviewed science validate, that's what Brain Maker was built on, but everyone is different. I mean, you have to experiment with your life and see what you tolerate and what you don't tolerate. So, I wouldn't say that's hugely unusual. It wouldn't be the strangest reaction I ever heard.
Back on the subject of probiotics, we've had a couple folks ask, what should one look for when buying a probiotic supplement?
That's a great question, and I think that's a moving target. And I really, what we want to be sure of is that you have viability in the supplement that you may be taking. In other words, that when you're taking a supplement, you've got to be sure that these bacterial organisms are going to remain alive and be alive at the time you take that supplement. So, you can find nutritional supplements that— probiotics that have a certain number, a certain billion number of what are called CFUs, colony-forming units, but that might be at the time of manufacture. So, you really want to look at products that are created in such a way and verified in such a way that the product actually contains at the time of consumption that number or close to that number of viable organisms. The other thing you want to look for is a pretty vast array of different types of organisms. I mean, it's all interesting that you might just take Lactobacillus acidophilus as one species, but that said, we want to look for a pretty wide array. In Brain Maker, I list the core 5 bacterial species that you should look for, organisms like Lactobacillus plantarum, Lactobacillus acidophilus, Bifidobacterium brevis, Lactobacillus longum, and these are all, I think, a very unique set of core species that are That are really helpful in healing the gut and in reducing inflammation.
We have a question. What is more effective, prebiotics or probiotics?
Well, I don't think you can do a head-to-head. We're talking apples and oranges here. You can't really do a head-to-head comparison of prebiotic fiber, which is helpful because it augments the growth of good bacteria in the gut, and as such has great clinical application. We've now seen a study recently published that demonstrated actually significant improvement in children with asthma by simply giving them prebiotic fiber. The probiotics and the probiotic foods, the fermented foods, kimchi, fermented beverages like kombucha and cultured yogurt, for example, are foods that actually contain high levels of probiotic organisms. I'm not trying to get away from the question, but the point is these things work synergistically. These things work together, but they come at the problem from kind of opposite ends of the spectrum. They work together to augment the growth of good bacteria, so I think as we talked about in Brain Maker, it's really good to have both of these on board. They're really good choices.
Is kombucha enough, or do you need to supplement?
So, kombucha is going to give you an array of organisms, and I would say that adding fermented foods, other fermented foods like kimchi, like fermented dairy products, are going to give you different arrays of organisms. It'll probably take us to the topic of how do you protect your microbiome in the first place, so maybe I'll take a breather here and hope that somebody asks that question. Knowing you guys, it's probably going to be the next question, right?
I'll give you a little transition there. We have somebody asking, what's your take on MCT oil versus coconut oil?
Well, coconut oil is a source of MCT oil, and I think if you're really going for the powering up of your brain in terms of keto— ketogenesis and becoming ketotic, I'd say go for the MCT oil. But I would also say that I think that there are other Health supportive properties of coconut oil that are not in refined MCT oil. So it's not necessarily a straightforward answer. At the end of the day, I think I'm going to probably vote for the coconut oil as being a better product and making sure that it's an organic product. Very, very high in saturated fat, that's actually good news. More than 90% of the fat in coconut oil is saturated. And the latest literature that just came out, published about— well, it wasn't the latest literature, but some literature that came out was published 3,000 years ago in the Vedic texts that calls our attention to the life and health supportive properties of coconut oil.
Follow-up to that, how much coconut oil do you recommend?
I think a tablespoon or 2 each day is reasonable. You can use it, put it in your coffee. For example, that's become extremely popular these days. You can use it as an additive to your foods when you're cooking. So I think 1 to 2 tablespoons a day for an adult is a reasonable dosage.
Someone's asking here, in addition to going gluten-free, how important is it to go sugar-free?
Fundamental. So we're— these questions are sort of dating back to Grain Brain, and as you know, that was the central thesis of Grain Brain, that is go gluten-free and get rid of the sugar, get rid of the carbs. And that said, how intriguing it is now that the United States Dietary Advisory Committee came out about 6 weeks ago and affirmed that we've all got to cut back, well, not everybody, but those who are eating carbs and sugars have got to cut back on their consumption of these things because this is where we're running into trouble. It's not the fat. Fat is your friend, we've got to welcome fat back to the table, and I think these 2 things run hand in hand. Refined sugar is detrimental directly to your body, increasing inflammation, increasing the production of free radicals, and as we discussed now in Brain Maker, sugar, a high sugar diet changes the milieu, changes the complexion of the bacteria in your gut. And creates an array of bacteria that favor inflammation and favor the extraction of more calories from your food, paving the way for things like diabetes and obesity. So, you know, it's huge. The most important factor influencing the health of your gut bacteria is in fact your food choice.
Okay, this one just came in. What is your opinion on vegetable juicing?
I love vegetable juicing, and I think the issue is to make sure that you choose your vegetables wisely. And the, for example, you know, you can have a nice 12-ounce glass of carrot juice, and that may seem like, you know, manna from heaven, but the bottom line is that's a very powerful sugar load. So, I think if you're juicing low-carb vegetables, you know, put leafy greens, for example, put broccoli into your vegetable juice. juice. The only downside, the only downside, but one of my objections is the fact that when you do that, most juicers are extracting the pulp, and the pulp is where the fiber lives, and the fiber is not this inert crap that you want to throw away. It's very, very important, as we're now learning. It's important for the gut. So, there are a couple of juicers that are out there that will allow you to gain back the fiber while you're extracting the juice and getting the benefits of the juice as well. So that stuff that most people seem to be throwing out, that's very, very valuable.
Great.
Dr. Perlmutter, what recommendations do you have for children who exhibit symptoms of ADHD, undiagnosed or otherwise? And if they're already taking a probiotic, what other suggestions do you have to improve their gut health?
So ADHD is a big issue here in America. Beyond children, we now know that 4% of American adults have been given that diagnosis. And as far as our children go, more than 6.4 million American children now carry that diagnosis. And 2/3 of them are receiving medications, the long-term consequences of which are not even understood, have never even been studied. So what happens is kids start looking out the window in school and are not getting their homework turned in on time. The next thing you know, they're being put on amphetamines. That's what's going on. I shortened it up a little bit, but the reality is that's what's happening, and I think that's scary business. When we recognize that 85% of the ADHD drugs used on the planet are used right here in America, that should tell us something. So I find that when we reduce inflammation in children, they're much more able to pay attention in school. And inflammation, as you will read in Brain Maker, is coming from From the gut. So we've got to target the gut right off the bat. And it happens to coincide with how that child was born in the first place. There's a tripling of risk of ADHD in kids born by C-section. Why is that important? Because when a kid is born naturally through the birth canal, that's when he or she obtains his or her first exposure to bacteria that live in the birth canal. That's how they create their first microbiome. Kids born by C-section don't have that opportunity, and that might well be what increases their risk for ADHD. The next fly in the ointment is the massive bombardment of a kid's gut bacteria that happens when they are given antibiotics with every sore ear or every cold or every sniffle. We've got to stop doing that, and it's not just me saying that. We're, you know, we're reading reports in the Journal of the American Medical Association And in The Lancet that are telling us that we're not doing our kids any service by loading them with antibiotics. In fact, we're paving the way for gut issues that lead to inflammation that may well explain the increased risk of ADHD in children who've had multiple exposures to antibiotics. So from a preventive standpoint, the keys are number one, avoid C-section if that's possible. It's a wonderful procedure, but it's Grossly overused. One-third of births in America now happens by C-section. Number two, try to back down on the antibiotics that kids get. Number three, do your very best to breastfeed your children. If in fact there is this diagnosis that kids are not paying attention in school, I'm a big proponent in terms of gut rehab with lots of probiotics. But beyond that, we found great success in using an omega three. Mm-hmm. That you can get at your health food store, that's called DHA. So this is not just, again, me telling you that. A wonderful study from Israel looked at actually treating kids with ADHD by just giving them this omega-3 that you can buy at the health food store with no prescription. So what I'm saying is prior to filling that prescription for whatever the drug is, the amphetamine, the stimulant drug for ADHD, consider going gluten-free, cutting back on the kid's sugars, adding in a probiotic, adding in DHA, and I would certainly give that a shot.
So, a couple questions. You mentioned Brain Maker. How is Brain Maker different than Grain Brain?
The central tenets of Grain Brain focused on the effects of eating too many carbohydrates, Not getting enough fat to nurture the brain, and the powerfully detrimental role of gluten as it relates to inflammation and as it directly relates therefore to the brain. What we now understand that to a significant degree, those factors described in Grain Brain— gluten, sugar in the diet, high carbs in diet, lack of fiber, lack of good fat— do their damage By altering the gut bacteria, altering this 100 trillion organisms that live within your gut, should now be considered as an organ in and of itself. A 3-pound area of your body that controls virtually every aspect of your metabolism, controls inflammation, which is the cornerstone of ADHD, autism, Parkinson's, multiple sclerosis, arthritis, diabetes, and cancer. So we now have, through Brain Maker, a full understanding as to why the dietary recommendations in Grain Brain were absolutely on target. But what Brain Maker now talks about is, first of all, what are we doing to our gut bacteria that paves the way for disease? What are the issues in our environment that we can avoid that are paving the way for brain failure. That's the key of Brain Maker. And beyond that, the empowering part of Brain Maker is therefore, what do I do to fix it? How can I fix this problem? And that's what's going on with this book. And, you know, it's now the number one book in America in neurology and neurological diseases on Amazon, and it's because people are finally making this connection between the gut and the brain. These are not disparate organs that live apart from each other. Everything going on in your gut that is dictated by your dietary and other environmental choices is directly affecting your brain right now and determining the destiny of your brain in the long term. That's what Brain Maker is all about.
So, is dairy toxic? Like gluten?
There are some people who don't tolerate casein, cow's casein, and they probably can identify themselves by having issues when they use dairy products. Well beyond being lactose intolerant, they may have reactions when consuming dairy products. But unlike lactose, these are people who have reactions that are not immediate. They don't get diarrhea immediately, but they may— if they stop consuming dairy products and therefore casein, They may have improvements that may take days or weeks. So it's an issue for some people, but certainly not to the scope that gluten-containing foods are in terms of population numbers.
Great. So we've had someone else ask, you know, on the topic of oils, besides MCT, besides olive, are there any other oils you recommend that we incorporate into the diet?
I sure do. Oil is basically liquid fat. And it takes us to this discussion of the fats that we consume, of consuming things like grass-fed beef, wild fish that's rich in oils, rich in omega-3s like DHA, free-range eggs, free-range poultry, nuts and seeds. Those are some good sources of what are called monounsaturated fats. So those are some other oil-type foods foods that do contain oils, I think you should absolutely gravitate to. Those are really helpful for you, and, you know, keep in mind though that I really want you to welcome back to your plate some of the fermented foods, and many of you have never had fermented foods, so that will be a first time for you, but understand that even sauerkraut is fermented, pickles are fermented, and you can now have at the grocery store fermented meat, fermented fish and even fermented eggs. So I really want you to start to embrace that as being a really important key to health and also recognize again how important it is to have prebiotic fiber at your— on your plate a couple of times a day. And those are foods like dandelion greens, jicama or Mexican yam, Jerusalem artichoke, garlic, leeks, onions. And you can even buy great sources of prebiotic fiber like inulin in the form of things like acacia gum that you can find at the health food store. So these are the keys to health, these are the ways that you're going to rehab your gut bacteria, reduce autoimmunity, reduce inflammation, which is what Brain Maker is all about.
Now on the topic of supplements, we've had somebody ask, What's your take on, and do you suggest cod liver oil and/or vitamin D?
Yes and yes. I think pharmaceutical-grade cod liver oil, in other words purified cod liver oil, is a terrific source of DHA. We talked about DHA earlier in terms of its role in terms of reducing inflammation and helping as an antioxidant, but beyond that, DHA actually amps up your body's production of what's called BDNF, brain-derived neurotrophic factor, growth hormone for the brain. So, I'm down for cod liver oil, and I think most of us are careful not to get too much sun anymore, and really it's been only very, very recently that we've put clothes on. So, you know, our bodies are designed, don't take this the wrong way, but to manufacture the right levels of Yeah. To make enough vitamin D, we pretty much need to run around naked all the time and not take cholesterol-lowering drugs because your body in the sun, no clothes, uses your body's cholesterol to manufacture vitamin D. So, we're taking away our ability to make vitamin D on all counts. So, I'm very big on vitamin D3 supplementation with the caveat that you should have at regular intervals, maybe once or twice a year, your doctor check your vitamin D level and make sure that it's about in the middle of what is called the therapeutic range. Now, the therapeutic range goes between 30 and 100 nanograms per milliliter. I think that's right. Well, it's 30 and 100 here in America. It's a different parameter in Canada. So, I'd like you to shoot for maybe 60, 70, or 80 on that scale as opposed to Your level being 34 and your doctor saying, oh, you're in the normal range, not good enough in my opinion.
So, when is the right time for probiotics?
Well, sometimes, somebody once asked me, what's the best time to go fishing? And my answer is anytime. So, probiotics, I'd say anytime. Ideally, it'd be good to take your probiotics in the morning. On an empty stomach before you've eaten, because the biggest gauntlet for the probiotics is getting by the stomach acid, and once you've eaten, you've amped up your stomach acid production, so you really want to hit those probiotics early on before you really have eaten and start turning on stomach acid.
Now, we actually just had somebody come in from Twitter and ask on the topic of artificial sweeteners, the damage that they can do to our microbiome as well. Well documented. Does that go for stevia as well?
I think that's not so much. I think stevia is a quasi-natural product, as you know. It actually comes from a plant, and as such, I think people can get away. If you have to have, if you have to have a sweetener, I think using some stevia is not the worst idea. I actually have recipes in Grain Brain using stevia. If you really must, you're not going to eat a food unless it has some sweeteners. I think you can get away with stevia. So, I think that's reasonable. However, the literature with respect to changes in the microbiome as a consequence of exposure to artificial sweeteners, non-natural sweeteners, I think is very, very compelling. And I think that the new research out of Israel that looked at the changes in the microbiome from artificial sweeteners is paving the way for diabetes type 2 is very, very compelling, as well as weight gain from eating— from drinking non-sugar-containing beverages, virtually beverages that are calorie-free making you fat. Who knew? Turns out that what the Israeli researchers demonstrated actually in their study was that this is happening because of changes in the microbiome, changes in the gut bacteria All right,
so I'm just gonna let everybody out there know we're gonna do about another 5 minutes here, so if you have questions, get them in now. And the next question we have also, somebody just sent this in here and they said it on Twitter earlier, you know, for someone who might have a family member with dementia or Alzheimer's that's currently in a nursing home or an assisted living facility, what are the sort of questions and things we should be talking to the caretakers about to help make sure that our loved ones are getting Right treatment.
Well, I've been through that, and I will tell you that making the changes at the nursing home or assisted living facility is very, very difficult. By and large, the food choices available are awful, and making changes in those food choices is very, very difficult. So you kind of have to do it yourself. If it's The kind of facility where you can stock the refrigerator, make changes, that's really good. And again, the diet that I use in my practice is one that is extremely low in carbohydrate. We know that elevations of blood sugar are absolutely toxic to the brain. Even mild elevations of blood sugar pave the way for dementia, as published in August 2013 in the New England Journal of Medicine. So So, it's a diet that's higher in fat. If it could be ketogenic, that's good. You don't want to do that, of course, if the patient is diabetic already. You want to be able to titrate the vitamin D level up, as we've talked about, but now we know that Alzheimer's is an inflammatory condition of the brain. We've got to do everything we can to reduce inflammation, and we actually dedicated a significant part of the book in talking about this and actually cite data from England, from Oxford, that looks at the relationship of gut bacterial changes, reduction in the diversity of gut bacteria, to risk of developing Alzheimer's in those countries where we've lost gut bacterial diversity. That's basically Western countries as opposed to places like sub-Saharan Africa where they've got a much richer Richer array of bacteria in the gut and their incidence of Alzheimer's is dramatically lower. If you have a loved one in a nursing home, you've got to get them to exercise every day. If it's walking with the walker, that's cool. If it's— if you can get them on a stationary bike, that would be fantastic. So exercise increases brain-derived neurotrophic factor and in Studies published in the Proceedings of the National Academy of Sciences, Dr. Ericsson has demonstrated actual improvement in memory in individuals who engage in aerobic exercise. Why? Because aerobic exercise turns on the growth of new brain cells and is in fact the most powerful medicine you can get, prescription or non-prescription.
You mentioned exercise. Somebody just commented, what is your opinion on burst training exercise?
I— that's become very popular and I think there are certainly upsides to that. But in addition, as per the New York Times last week, we're now learning that in comparison studies, at least for adults, that less strenuous exercise over a more prolonged period of time seems to be associated with reduction Of risk of early death and basically longevity. What we do know, at least in terms of the brain, is we need the aerobic part of the equation. So with interval training, for example, when you reach a higher heart rate, and I don't— you don't know— I can't tell you what heart rate that would be. What I generally recommend to patients is choose a heart rate of 180 minus your age as a very, very crude estimate of where you should target if you're in reasonable shape. You want to try to hold that heart rate for 20 minutes. That is what has been demonstrated to be most effective in terms of bumping up your BDNF, leading to the growth of new brain cells, leading to the better synaptogenesis, the connection of one brain cell to the next.
One last question. Okay. So probiotics and diarrhea, is that a good combination or a bad combination?
Well, as a matter of fact, probiotics are used to treat diarrhea, and in multiple studies in children, it's been demonstrated that those kids taking probiotics, especially in third world countries, have significantly lower risk of getting diarrhea. And as you may know, in some third world countries, this is a major cause of infantile and childhood death. So we can offset that. By paying attention to gut bacteria and in this case intervening with the use of probiotics. That's an excellent question. And I will tell you that you'll hear a lot more from our team about our outreach to make probiotics available in third world countries moving forward over the next couple of years. So that's our last question. Let me say thank you for all of you who participated. Today's the launch of Brain Maker and it's going really, really well. We're already getting positive commentary on Amazon and I will be on Fox and Friends this Saturday morning. I don't know what time yet, but watch that. And if you want to, go to the media page of drperlmutter.com. That's drperlmutter.com and you can see tomorrow I'll be in many cities around America with satellite uplink, and maybe I'll be in your hometown, who knows. But a lot of online interviews, a lot of podcasts are coming up as well, a whole bunch of them. So pay attention to those, and I'm hoping that you find this information helpful. Let me just ask my team here if there's anything I neglected to say.
Wonderful. I would just say if you didn't get your question answered today, be sure to join Dr. Perlmutter on Twitter and Facebook. Facebook, Dr. David Perlmutter.
And also give us your feedback as well on how this went this evening because it's— the technology seems really easy and I'm happy to do it again and again.
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