David PerlmutterPresident,, Perlmutter Health Center · Board-Certified Neurologist | Functional Medicine Pioneer | #1 New York Times Best-Selling Author | International Speaker | Host of The Empowering Neurologist Podcast

This Drink May Lower Your Alzheimer’s Risk

7 Jan 2026 · 1 min

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1:08

In this short YouTube video, board‑certified neurologist Dr. David Perlmutter explains recent research showing that components of espresso coffee—specifically genistein and caffeine—can reduce the aggregation and misfolding of tau protein, a hallmark of Alzheimer’s disease. He connects this mechanistic finding to long‑standing epidemiological data that higher coffee consumption is associated with a lower population‑level risk of Alzheimer’s. Dr. Perlmutter concludes by inviting viewers to follow his channel for more nutrition‑focused neurology information.

Chapters

Consumption of this beverage may well reduce your risk for Alzheimer's disease. Hi folks, I'm Dr. David Perlmutter. I'm a board-certified neurologist and also fellow of the American College of Nutrition, and we've been looking at various nutritional inroads to helping reduce risk of Alzheimer's disease for an awful long time. It turns out that researchers studied a particular beverage as of late, and certain components in that beverage actually reduced the aggregation and the misfolding of a protein in the brain called tau protein. It turns out that this beverage is nothing more than espresso coffee, and contents of that espresso coffee, things like genistein and even the caffeine, were found to help reduce the misfolding of this tau protein. That is a finding in the brains of Alzheimer's patients. So this is actually very good news indeed and does support the data that we've seen for years that associates increased coffee consumption with reduced risk for Alzheimer's, at least at a population level. I'm Dr. David Perlmutter. If you like more of this type of information, please follow my channel. Bye for now.