Why Brain Science Is Shifting in a New Direction
In this brief monologue, board‑certified neurologist Dr. David Perlmutter argues that Alzheimer’s disease should be understood primarily as an immunological disorder rather than a condition caused by beta‑amyloid accumulation. He notes that massive investment in amyloid‑targeted research has yielded little therapeutic benefit, and that the underlying issue lies in the brain’s immune cells—microglia—which can shift from supportive to pro‑inflammatory states, driving neurodegeneration. Perlmutter emphasizes that inflammation is the key factor that “makes a good brain go bad.” He outlines practical, non‑pharmacological ways to reduce neuroinflammation and restore microglial function, including diet, regular exercise, adequate sleep, stress reduction, and maintaining social connections. He invites viewers to follow him for more information.
