Why L-Arginine and L-Citrulline Do Not Increase Nitric Oxide

11 Nov 2025 · 0 min
Episode

11 Nov 2025 · 0 min

0:00

This podcast episode (hosted by Dr. Anne Truong) explains why oral L-Arginine and L-Citrulline supplements often fail to raise nitric oxide: much of the supplement is lost via first-pass metabolism in the gut/liver and conversion requires a functioning nitric oxide synthase (NOS) enzyme, which the speaker claims declines with age. The host recommends obtaining nitric oxide via diet/bacterial conversion (arugula, beet, sunflower seeds), nasal breathing, exercise, and avoiding fluoride mouthwash/antacids; she also promotes a proprietary arugula-extract nitric-oxide capsule and related coaching/resources for erectile dysfunction.

Questions this episode answers

About 50% (speaker's claim).

Arugula extract (and specifically no L-Arginine or L-Citrulline).

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