Does Benadryl Work?

18 Oct 2021 · 4 min
3:48

Dr. Lera (Dr. Larry) discusses whether Benadryl (diphenhydramine) works for pet allergies. He states Benadryl is effective only about 5–10% of the time for typical (mostly seasonal) allergy-related itch in dogs, is less likely to help food allergies, and is much more useful for anaphylactic or vaccine-related reactions. He notes generic diphenhydramine can be used but dosage should be confirmed with a veterinarian, and advises starting Benadryl about an hour before vaccination and continuing every 12 hours for 24–48 hours when preventing vaccine reactions. He also mentions evaluating for secondary infections and considering alternatives (apoquel, oclacitinib, cyclosporine, etc.) for persistent allergies.

Questions this video answers

About 5 to 10% of the time.

Diphenhydramine.

About an hour before vaccine administration.

Continue for another 24 to 48 hours afterwards, giving it every 12 hours.

Chapters

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