Jeffrey Bland, PhDPresident of Big Bold Health | Human Health Thought Leader

"Epigenetic Modulation" of HTB on immune cells

9 Sept 2024 · 1 min

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Transcript excerpt from a YouTube discussion where Jeffrey Bland, PhD describes a clinical trial testing 'Himalayan Frederic Buckwheat Polyphenols' for epigenetic modulation of immune cells. After 90 days of intervention the trial found 223 differentially modulated CpG sites (interpreted as changes in epigenetic regulation affecting over 200 genes) correlated with shifts in immune cell subpopulations, implying altered 'immune personality'.

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What I'm sharing with you here, I think, is the work of my life. This clinical trial that we did is quite remarkable. I think it's the only and first clinical trial of its type in which we looked at epigenetic modulation of immune cells before and after intervention. After 90 days with Himalayan Frederic Buckwheat Polyphenols, and we found 223 differentially modulated CPG sites. What's that mean? It means there were over 200 different genes that we could see over 90 days change their epigenetic regulation of gene expression, which we could correlate with different subpopulations of immune cells. We're actually changing their immune personality over 90 days.
What you're saying is, basically, when you eat these plant compounds, like Himalayan tyranny, Buckwheat has these polyphenols that change gene expression across over 200 genes that modulate our immune system and our immune health.
Yes.