Jeffrey Bland, PhDPresident of Big Bold Health | Human Health Thought Leader

July 2011 FMU part 2 featuring Edwin Lephart

26 Jul 2011 · 1 min

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1:28

Interview excerpt (July 2011) with Edwin Lephart describing research on “Equil” and its effects on skin biology. Lephart reports in vitro and gene-array data (≈40 genes examined) showing that Equil at very low concentrations (10 nanomolar in vitro) enhances collagen and elastin expression while decreasing matrix metalloproteases (MMPs) that degrade those proteins. He also states Equil stimulates antioxidant/anti‑aging genes and that the compound has been translated into a commercial cosmetic product with positive skin‑health effects.

Questions this video answers

40 genes

10 nanomolar

Matrix metalloproteases (MMPs)

Chapters

We've done a great deal of research examining equal and the enhancement of skin health, both in vitro data and also gene array data. And we've looked at 40 different genes and in general equal will enhance collagen elastin, which are really important dermal proteins for skin health and at the same time will decrease the matrix metalloproteases. And there are many different molecules and these matrix metalloproteases have the ability to break down collagen elastin. And so what we found in the gene array studies and also in the in vitro studies, equal at very low concentrations in vitro at 10 nanomolar will enhance collagen expression and and elastin expression but also at the same time decrease this enzyme that breaks down collagen elastin. The mmps. If we look at the antioxidant arm for Equil, it's a great stimulator for many different anti aging and antioxidant genes. So this particular aspect of our research has been translated and Ecwal is actually used in a cosmetic product currently and it has really positive effects for skin health.