This is a YouTube video titled "Dr. Nayan Patel: Unlocking Glutathione Your Body’s Super Antioxidant | TUH #057" created in April 2024. It features a conversational podcast format with Gary Brecka as the host and Dr. Nayan Patel as the guest. They discuss the importance of glutathione, a critical antioxidant in the human body, its role in aging, detoxification pathways, and challenges related to its delivery and synthesis. The conversation delves into biochemical and health-related topics such as methylation, liver enzyme function, and antioxidant benefits.
So if you can age, let's see, every six months, you only age one month. Wouldn't that be better?
That'd be great. You got everybody's attention right now. What was astounding to me when I started my wellness practice was the paucity of knowledge and understanding about this miracle antioxidant. I understand it to be the most prevalent antioxidant in the human body. Every single cell in our bodies contains glutathione. It's manufactured by our liver. But I feel like it's the mother of all antioxidants that most people have never heard of.
The reason we don't talk about glutathione, even though we have known for glutathione for over 100 plus years, we have never figured out how to.
Hey, guys, welcome back to the ultimate human podcast. I'm your host, human biologist Gary Brecker. Where we go down the road, everything anti aging, longevity, biohacking, and everything in between. And today's guest, as you just heard, is a powerhouse. I actually met him at an A4M conference. This is the big Age Metal Medicine conference. That's, that's hosted once or twice a year all over the world. And I was actually absolutely enthralled by some of the products that he was developing as a pharma, as a pharmacist. Not only his background as a professor, but also his, his thorough understanding of transdermal delivery in certain, not just pharmaceuticals, but certain things like glutathione and other things that we're trying to get into our bodies, that we're trying to avoid first pass metabolism, which is our digestive system, because our digestive system is a very inhospitable place. And it's, it's a very difficult route for delivery into the body. And let's just face it, a lot of people don't like to do IVs and they don't like needle sticks. And so they're looking for other mechanisms to deliver, not just pharmaceuticals, but hormones and antioxidants, vitamins, minerals and nutrients of all kind. So this is going to be an amazing podcast today, and I really want to welcome Dr. Patel to the podcast. It's great to have you on.
It's my pleasure to be here today, Gary.
And, and truth be told, right before we started, Dr. Patel told me that his wife is a fan of mine and she follows all my videos. Right, and what forwards them to your.
Friends, to my kids and my. Her friends.
Everybody see your kids, your friends. So great. We already know that Your wife's a good person. So we don't, we don't need to cover that. But you know, I, I, I, I, I want to just get right into it because I'm, I'm fascinated by your research into glutathione. And I'll tell you what my understanding is of glutathione. It's probably, certainly not as in depth as yours. And I, I think most of my audience has heard of it. But what was astounding to me when I started my wellness practice was the, the paucity of knowledge and understanding about this miracle antioxidant. I understand it to be the most prevalent antioxidant in the human body. Every single cell in our bodies contains glutathione. It's manufactured by our liver. But in times of stress, or when the liver is under stress especially, you see glutathione levels drop and therefore you have all this whole myriad of consequences. But I feel like it's the mother of all antioxidants that most people have never heard of. Like if, if I think if you took up, let's say, a slice out of middle class America and you said, you said, what's the number one antioxidant in the human body? They would say things like vitamin C. That's right. Or, you know, blueberries have antioxidants. And so I, I would love for you to take us down the road of, you know, what glutathione is, what's its role in the human body, why is it so important? And then I want to transition into the different delivery mechanisms and how people can benefit by adding glutathione to their regimen.
Absolutely. And you said, right, people don't understand antioxidants because they used to, or drink orange juice per day. There's all the antioxidants in there.
Right.
And so, or eat blueberries or blueberries, whatever. Right. So they are, they're trying to get the antioxidants from the food source, which is, which is the right thing to do because we want them to eat the right types of fruits and vegetables every single day. But the reason we don't talk about glutathione, even though we have known for glutathione for over 100 plus years, is we have never figured out how to get inside your body. So even though we inject it, take a pill or inhale, like I have a lot of athletes, they'll inhale a glutathione or they may do a suppository or whatever, Whatever they say.
So they vaporize it, nebulize it.
And so they think that they're getting into the system, but it's not there. So we'll talk about the delivery system next, but let's talk about what is it. Right, so the glutathione. And you said right now most of the people have not heard about it because of the fact that people do not understand what it is and how to deliver that part. But you talk about middle America, but even people that have very affluent. We were recently at one of the award shows and literally 90% of the people these are high powered CEOs have never heard of glutathione before. And I was shocked to see this. And wait a second, you have all the resources in the world, yet you have no idea what glutathione is. So we are talking about glutathione. First thing, it's the simplest peptide the body produce. I say peptides. This is a three amino acid.
It's three amino acids.
So it's a tripeptide. It's not a protein. I feel it could be a protein, but not really. It's a tripeptide, very simple form.
It's.
And when you combine those three amino acids together, it has more than one properties. And that's what we want to find out. What are the properties? Because if something just does one thing, it's good. It's a mother of all antioxidants. That's just one of the function, right? Because as a glutathione, what it does, it quenches all the free radicals. Because our body is exposed to free radicals all the time. That's one. On top of that, our body produces free radicals because of chemical reaction happens every single day in our life.
Yeah, chemical waste.
Yeah, chemical waste. So the free radicals are inevitable. It's always going to be in our body. And that's how you always going to be aging. Only thing that you can control is the pace. It's not if it's the pace, right? So if you can age, let's see, every six months, you only age one month, right? Wouldn't that be better?
That'd be great. You got everybody's attention right now, including mine.
So that's what we want. That's exactly what we want. And so the pace of aging has to be done. And the free radicals are always going to be produced. So that's one of the functions. That's what it's known for. The second part that nobody talks about this thing is glutathione actually helps with phase one, phase two detoxification pathways or for making sure activates the liver and, and basically helps get rid of all the chemicals we exposed to.
You know, I don't want to cut you off, but. But before we get further, I want to talk about phase one and phase two detoxification because I'm. I'm a huge fan of methylation and decided to dedicate the balance of my adult lifetime to the study of methylation. And these methylation pathways dump into two main pathways. One is transulfuration and the other one is glutathione synthesis. And we absolutely see impaired methylation leading to poor glutathione synthesis having demonstrative consequences in the onset of the severity of, and eventually how quickly people succumb to disease and pathology. I assume that it must have something to do with the inflammatory process or what have you. So can you talk a little bit about phase one and phase two detoxification when you use those terms? What are you referring to for the audience?
I'm looking for those liver enzymes. I'm making sure the CYP enzymes, which one hasn't been, is not clearing up effectively. Because if you are exposing yourself to, let's say, hormones, and if you have CYP1B1 enzyme gene mutation, then it doesn't matter. All the hormones you're taking is actually working against you because your body cannot clear them out, right? So that's what I'm talking about. So there's a lot of medications that you take, a lot of foods you eat that your liver has to clean out. And if you have one of those gene snips that your body cannot metabolize it or conjugate it, you have an issue with buildup of all this medication in your body that is actually working against you. The second part, you talk about the com, the methylation transferase as well as the glutathione transferase. Glutathione transferase is a protective system that is activated because the need for glutathione has increased so much so the body activates those systems to produce glutathione. Now it needs three things, right? Three amino acids.
