Gary Brecka connects frequent migraines to low sodium levels, citing a Wiley Journal of Headaches study showing an inverse relationship between serum sodium and migraine frequency. He describes his own near-daily migraines unresponsive to NSAIDs and triptans, and notes that headache pain actually comes from structures outside the brain, not the brain itself.
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What I am saying is there is evidence that sodium deficiency does trigger migraines. I experience migraines almost daily, and conventional treatments—NSAIDs, triptans, preventative medications—provide minimal, if any, relief. I'm at my wit's end, and I want to investigate root causes rather than just masking symptoms. Could this be related to my MTHFR gene mutation, or affecting methylation, or neurotransmitter production? There was a very interesting study that was published in the Wiley Journal of Headaches, and what it looked at was the inverse relationship between migraine headaches and sodium. And what they found was that as migraine headaches went up, sodium levels were down. As migraine headaches went down, sodium levels were higher. This might be controversial and it might be counterintuitive to how you think about sodium, but think about this: headaches do not come from your brain. Your brain has no pain receptors in it. The brain is not capable of generating a pain signal. When you think that your head hurts or your brain hurts, it doesn't. It's not generating the signal.