COMT Gene Mutation: How to Supplement For Better Sleep and Reduced Anxiety | TUH #026

Ultimate Human.

Hey, guys, welcome back to the Ultimate Human podcast where we go down the road of everything anti aging, longevity, optimal health, biohacking, and everything in between. My guest today. Actually, I don't think I should call her a guest. Should I call you the co host? Yes, co founder.

Okay, all right.

My co founder, habitator.

You're the best thing that ever happened to you.

The best thing that ever happened to me. My wife, Sage Workinger, soon to be, soon to be Sage Brea. In any case, today's podcast is about the genetic mutation C O M T. We spend a lot of time talking about genetic methylation. You know, this process of how the body takes raw materials that enter the human body and converts it to the usable form. But we rarely actually take time to pull out one genetic mutation and explain it so that if you're listening and you have these types of characteristics and you've just accepted it as a consequence of aging or a consequence of your lifestyle or your career or your diet or what have you, it may not be a consequence of any of those things too. It may, since it simply be a consequence of missing raw material in the human body. The reason why we chose this gene is because someone to my right has this gene mutation.

Someone to my left does not, which is why we are like the opposite when it comes to personality.

So let's talk about what C O.

M T, which stands for catecholomethyltransferase. That's not important. What this gene really controls is it controls a few things. Number one, it downregulates a category of neurotransmitters called catecholamines. Now, that might not sound like a big deal, but catecholamines are fight or flight neurotransmitters. And when they rise in the brain, they create awakened state. If they rise to a very high level, they create a frightened state, an anxious state, or they could even create a fight or flight response. And so if we have impaired ability to regulate these, then there are certain consequences. And some of the other things that it affects are estrogen metabolism. We're going to talk about estrogen.

So.

So let's just talk about your journey with this gene mutation before we even knew that you had this genetic mutation. Like what kind of things were going on?

Oh, so many fun things. Such as one weird topic that I don't think I ever. I'm 45 years old. I don't think I've ever shared this with anybody. But before I started to supplement for my genetic breaks, of which I have many. I would fall asleep. Well, I would try to fall asleep, and then as soon as my head hit the pillow, even if I was exhausted from the day and thought I'd sleep so well, my mind would turn on and I would have show tunes, songs that I don't really. Yeah, I don't even go to Broadway plays, but I'd have these show tunes just running through my head, or a song I heard on the radio or. And I. And I would have that all throughout the day too. And I just sort of thought that was normal. So until I started talking to people that don't have this Jean break and.

They'Re like, you don't have. Have show tunes in your head at night. That's weird.

And then I. I just. I overthink everything.

No, I know.

No, I'm a worst case scenario person.

Which sucks, because when there's a knock on the door and you think it's a murderer.

Every time.

Yes.

Every time.

There was that meme that was so funny where it was like a knock on the door and it's either a murderer or maybe the positive thinking book I ordered on Amazon.

Yeah, that's both. You.

That was me to a tea. But I over. I'm a. I'm a perfectionist. I have. I have ocd. But, you know, the more I read about ocd, it's not like the light switch flipping on and off kind of ocd, but it's. I like things in their place. I like things very organized. I like my phone charger where my phone charger is supposed to be. And I hate it when somebody to my left.

Yes.

Moves it out of place on a regular basis.

Yeah. And, you know, when we put some science behind what could be causing what is obsessive compulsive disorder? Like, what is OCD or compulsive neatness? I mean, when we lack organization in the mind, we crave organization in our outside environment, because it's one less thing that we have to deal with, one less disorganized thing we have to deal with. So a lot of people listening to this podcast will go, wow, I might have that gene mutation. Because when I go to study or work on a project, not only does the desk I'm working on have to be clean, but the room the desk is in has to be clean.

It's hard for me to work from home because if I see a pile of dishes in the sink or I know there's laundry to be done, I feel like I have to get those things done. Even Though that literally is not anything I need to deal with on that day. But once I take my vitamins, then I recognized what needs to be put first. When you get my emails done or phone calls made and not worry about the laundry, I can do that later, but it is hard for me. I actually have to work on that every day. Whereas you don't ever do that at all. No.

Dishes don't bother me, ever worry. Neither does laundry. In fact, not a lot bothers me.

No.

Yeah. So I don't have that gene mutation. But when you have this gene mutation, the other, one of the other consequences of these excess catecholamines is that as your environment quiets, your mind wakes up.

And it wakes up like all night long.

And so what does this mean?

It means that your body tired, but your mind awake. And I always talk about the kind of things that are going through your mind are the most innocuous little thoughts, stupid stuff.

It could be really important things too. Like I stress a lot about the things that need to get done, the.

Things I didn't get done, where nothing is particularly pressing, like in your business or your career, your relationship, you might find yourself thinking about, did I get everything on my grocery list today? Did my outfit match my shoes?

You know, I definitely don't care about that. But yeah, it's never a worry.

But these are always innocuous little thoughts that, that, that could easily wait until the next day. They don't need to be solved in that moment, but they're keeping your mind awake. And so once we start to put some framework to understanding, well, how is it that I'm body tired and mind awake, it's that these excess catechola beans, this category of neurotransmitters, fight orf flight neurotransmitters, ephedrine, ephedrone, epinephrine, or we also call adrenaline and dopamine. And, and when we don't down regulate these, the mind's in an awakened state. Sometimes it's difficult to understand that we don't just create thought, but we also dismantle thought, we actually break thought down. If not, we would always be thinking the same things or we'd always be in the same mood. And so if we have a slow process of degrading thought, transferring catecholamines, I mean, transferring methyl groups from the category of neurotransmitters called catecholamines, if we're slow at this, then the mind's in an awakened state. And not only is the mind in awakened state, but it's thinking and it's running through this loop. So like, what are some of the things that you do to address that? Because if somebody's listening to this and they go, okay, great. I really identify with her. I've got the show tunes, I've got the waking mind at night.

Well, I'm a perfectionist.

I have the perfectionism.

Yeah, it's. I always say when I, when I do lab review someone and I help them understand their compt break, I always try to show the good side of it because it really is a difficult gene break to have mentally. I always try to tell them that usually these are very successful entrepreneurs. They can't work for anybody else. They have a hard time, you know, taking direction. They hate, we hate to be micromanaged. If you try to micromanage me, I'm out.

Oh, yeah, I've tried.

Yeah, it doesn't work. So that's why we have to work for ourselves. And so that's a good sign because usually people, people become more successful that way.

They're also very dependable. They're very reliable. Yes, they're very thorough.

Very thorough.

You know, they're the kind of people you want in your, you want them on your team, intuitive.

You want them in your group project when you're in school and you want them on your team when you own a business.

Right.

If I look at somebody's gene breaks when they start with 10x health, we after three months, when somebody's with us 90 days, we actually give them the gene test. We provide that for them. And I like to look at employees genetic reports because it's, it helps me understand them. It helps me understand what they're thinking, what they're doing, how they react to things. And I can just communicate with them better, knowing their personality.

You know, the other thing that I wanted to mention before we give some specific supplement recommendations is, you know, early on when we were pulling your lab reports and looking at hormones, nutrient deficiencies, blood sugar control, one of the things that always would pop up was this mild elevation in estrogen. It always seemed to be slightly estrogen dominant. And you're extraordinarily fit, lean, you know, amazingly fit. Thank you. And I got abs for days. Actually, she does have abs for days. She has one of the greatest midsections any woman I've ever seen.

But when I was going through a period of time where I was taking the wrong vitamins, you had this little. Yeah, it was a bubble.

Turns out is the estrogen band right.

In my lower Section right below the.

Belly button, moving laterally around to the flanks and then back around towards like the kidneys. And this particular area will drive women crazy. We've had so many women come into the clinic and talk about, gosh, I just don't get it guys, I'm not eating. I have a cup of black coffee in the morning, I wake up fasting, you know, I go to orange theory for 55 minutes. I've been doing that five days a week for three months. I haven't lost a single pound. Like what is going on? And when you look at their hormones, you realize that they're estrogen dominant, meaning their estrogen is out of ratio. So it's retaining water in what we call the interstitial space, that space between cells. And it has a tendency to gather right below the belly button, laterally around to the flanks. But you also look at this compt the C O M T gene mutation and you realize it plays a magnanimous role, a very important role in estrogen metabolism. It sends estrogen down, what's called the E2 pathway to help it get, get rid of it. And if we can't get rid of estrogen, especially women, it rises and it causes this water retention. So these poor women that think they're fat are actually just retaining water. Yeah. And so if you have some of these personality characteristics, very organized, you know, obsessively neat, detail oriented, maybe people tease.

You about having a very difficult time meeting our protein needs. And certain protein sources like whey protein and others can be as little as 20% absorbable. This is 99 absorbable. And it has all of the essential amino acids that the body needs to build lean muscle, to recover, to improve our exercise performance and most importantly to repair, repair after we have intense exercise. So this is called perfect amino by Body Health. It's like I said, 99 absorbable. It only has two calories. Eventually the caloric intake has virtually no caloric intake. It will not break a fast. It tastes amazing. You mix it in water. I take this literally every single morning. If you're working out in a fasted state, you have to take a full spectrum amino acid prior to your workout to preserve your lean muscle and make sure that you're recovering properly. And again, it will not break your fast. So the caloric impact is virtually zero. You get all of the full spectrum amino acids. It tastes wonderful. I use it every single day. You can go to body health.com ultimate that's bodyhealth.com ultimate and look for the perfect Aminos, they actually come in capsules if you're on the go, or it becomes in several flavors that they make in a powder, which I love.

It's.

It's flavored with natural means of flavoring. So there's no artificial sweeteners in here. So this is one of my absolute favorite products. Give it a try. If you're working out at all, you need a full spectrum amino acid. Go to bodyhealth.com ultimate that's bodyhealth.com ultimate. I love their lab tested products. You can actually see the absorption rate for all of their products. They've got great electrolyte protein combinations. My favorite is the perfect Aminos. Bodyhealth.com ultimate and now back to the ultimate human podcast.

You know what another symptom too is? Sensitivities to texture. Sound. Hate loud noises.

She does.

Yep.

We had this bed in our house that you thought. I mean, you nerded out on it. You were like, this is the greatest thing I've ever had.

All the hydraulic lifts and everything.

No, the one with the loud, loud sound. The VEMI bed.

Oh.

Now the majority of our clients love it. Like even you would lay on it.

Meditation bed.

Yeah, meditation.

Uses vibroacoustics, red light therapy, pmf.

But we had it out in kind of the living room, den area of the house, and if somebody got on it, it reverberated through the entire condo.

You hated it. I remember.

I hated it so much. But you thought I was being dramatic until Pete Vargas came over and he hated it too.

That's right.

Remember?

And you had the same gene.

And I was like, see, Pete knows Pete. I'm not. I'm that crazy. And then you read about it.

Remember when you're in la, since I read about the hyper acuity.

And then that was when it, like, put it all together. Why does she get crazy?

You don't like a lot of bright lights, loud music.

I don't like a lot of people either. When it's like too overwhelming and there's too many people talking and.

Right.

I just. I have to back.

See, I love that. But she. You don't.

No.

So knowing that you might have some of these characteristics. Right. So somebody's listening and they go, wow. I lay my head on the pillow, my mind wakes up. I've got the show tunes and the active mind, and I don't know what my hormones are, but I do seem to have this estrogen band. And because I have these other characteristics, maybe I have this gene mutation. If you get tested for this gene mutation and you are positive for it. It's not the end of the earth. It's actually a very common gene mutation.

Makes so many things make sense.

Yes.

It's really helpful to know.

And so what have you done to mitigate it? Because now you're sleeping better. Your hormones are perfectly imbalanced. You clearly don't have estrogen dominance anymore. I certainly don't notice the level of obsessiveness that you know you have.

So the big thing in my diet was that I had to get rid of green tea. Green tea. Everybody's like, it's so healthy. It is, it's. It's a wonderful tea. If you don't have a comp tea.

Gene break, it's the quercetin in the green tea.

Is that. So that's what it's. Because I know then specifically you can't have quercetin. So a lot of. So during COVID I recognized that a lot of doctors were prescribing quercetin for their patients and recommending elderberry as a supplement. Your immune system. And if I had elderberry, quercetin and a green tea, you can guarantee that I'd have a panic attack and lose my mind and definitely I would not sleep. There was. I remember looking back that I had a green tea. Because you were green tea obsessed for a while when you're at the Ritz Carlton one night with some patients.

Yes.

And you were like, oh, it's good. You drink it right before you order your food.

Yes.

Remember I drank it and I did not go to sleep until 8 o' clock in the morning.

I remember that.

I was like, why? It's not something I regularly drink, but. And I definitely don't drink caffeine at night. But it affected me way more than if I had had a coffee.

Yeah. And quercetin, which is commonly found in almost all green tea and. And elderberry quercetin supplements. If you have this genetic break, you need to be very cautious about taking question because it will make your mind race. It will keep you up at night almost like a stimulatory effect because it creates this wake in mind state. And it can significantly aggravate the estrogen metabolism and further impair estrogen metabolism so that you become even more estrogen dominant and retain more fluid. Yeah. So if you think you might have this genetic mutation. I noticed that Sage's routine is she takes methylfolate 5mthf for a while. She used a supplement called Sam E which my.

That was a. I always tell people When I started the protocol, it took me about three tries to get it right.

Right.

Which could be because we were learning still. I think we've figured it out for a lot of people. But if anybody ever doesn't have the perfect reaction to the supplements, I always encourage them to try to, to mix it up and to try something new. And the addition of Sam E. Dr. Sarda kept telling me, I think you're going to really do well on it. So I added it in. And that first three days, oh my.

Gosh, I remember you were like the happiest person. You were like calling me going, I feel I'm the happiest.

So good.

I feel great.

I literally felt like this huge weight was off my shoulders. I was so happy. I remember that I called you. I was on 41 in Naples and I called you.

You sound like my wife.

I don't even know what's going on, but I am so frickin happy right now. And it was the addition of that Sammy, but it's not for everybody. So it's very. We don't ever put it on the first protocol for patients. We always, you know, see how they do with the other vitamin supplements and then potentially we add it. But Sammy was great. I take tmg, try methyl glycine, try methyl glycine at night, which helps me methylate better. I take a sleep formula pill, our capsule, our formula is melatonin, magnesium and theanine, which I love. And then my trick is to take 5 methylfolate at night as well because I have an mthfr break so that helps me quiet my mind and get into bed.

She powered through the night last night. I don't even, I don't think you got once last night. It was glorious.

It was glorious.

But you know, having this sleep routine with methylfolate, magnesium, theanine and melatonin, you know, and the trimethylglycine during the day.

Which you can take during the day or at night.

Yeah, you usually take it in the morning. But the, the interesting thing is something as simple as regular supplementation to support a genetic deficiency, a nutrient deficiency, can make all the difference in the world in the entire trajectory of your life. So many of you that are listening to this have these tiny little anchors off your stern that you've accepted as a consequence of aging. It's either weight gain or water retention or brain fog or poor focus and concentration or lack of short term recall or waking mind at night. Or you get up at night to use the restroom and you can't Go back to sleep.

Yeah, it's miserable.

Those things are not a consequence of aging. They are not something that you need to accept as a consequence of aging. These are generally a consequence of missing raw material deficiency in the human body.

And speaking of the raw material, so the, the B12 specifically that I take now, I have a yellow compt, which means I inherited it from one parent. So I can get away with taking either methylfolate, I'm sorry, methylcobalamin, methylcobalamin, or I could take. Yeah, which is a really good B12. Or I can take two better forms, which is hydroxycobalamin or adenosylcobalamin. But if you have a red compt, which means both parents passed on that genetic mutation or that genetic break to you, then you have to take hydroxycobalamin or adenosylcobalamin because those are the top two forms. You don't really do as well on methylcobalamin. Right.

So you could put it, to make it even more simple, if you have the choice over B vitamins, you could take a hydroxycobalamin or adenosylcobalamin form and not have to worry about it.

Yeah.

Because everybody can process, everybody can process that. And it's odd sometimes when we think, well, there's four forms of B12, um, three of them occur naturally in nature. One of them is actually synthetic. We can't stand it. It's called cyanocobalamin.

That'll turn me into a crazy person.

Yeah, you need to get that out of your life. If it's in any of your supplements. But your sanity, your sleep, your lack of brain fog, your focus and attention, your deep sleep, your non racing thoughts, your organization could be as simple and as far away as some very, very simple nutrient deficiencies. So I really encourage you, you know, to get that test done for the compt gene mutation. If you have any of those symptoms and begin to supplement for those and possibly change the entire trajectory of your.

Life, it will be a total game changer. It's, it's changed my life, significantly changed.

Both of our lives and, and, and the lives of thousands of our patients.

And I don't drive them as crazy as I used to.

This is, this is true. It actually has made our relationship a lot more common. I'm sure. I have Jean Brights that used to drive her crazy that are not anymore. So if you've enjoyed this podcast, please don't forget to like and subscribe below. This is the ultimate human podcast. And as always, that's just science. If you haven't had a chance to.

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