Darrian Peck explains why folic acid in prenatal vitamins can worsen postpartum depression for people with MTHFR gene mutations who can't convert it to active methylfolate. The FDA recently approved prescription folinic acid for autism and postpartum depression. Methylfolate supplements may be safer than standard folic acid.
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I find it really interesting that we are prescribing the methylated form of folate to treat postpartum depression, which is caused by the folic acid that we give to pregnant women. US FDA actually just approved a prescription strength of folinic acid for the first time for autism and for postpartum depression. My sincere belief is that the vast majority of postpartum depression is directly linked to the prenatal vitamin. If your body cannot convert folic acid into methylfolate, it will not only not prevent a neural tube defect, it will exacerbate anxiety, depression, anxiousness, postpartum depression. So why do so many pregnant women get postpartum depression? The vast majority of them have the MTHFR gene mutation and took high doses of folic acid. So the long and short of it is folic acid is your enemy and supplement with something called methylfolate.