The Secret for Resilient Brain, Stellar Health & Longevity with Dr. David Perlmutter & Jim Kwik

14 Feb 2022 · 38 min
37:58

In this episode of the Kwik Brain Show, host Jim Kwik interviews neurologist and bestselling author Dr. David Perlmutter about his new book Drop Acid. The conversation centers on uric acid—a metabolic by‑product of purine, fructose, and alcohol metabolism—and its role as a powerful signal that drives fat storage, raises blood pressure, spikes blood sugar, and amplifies inflammation. Elevated uric acid is linked to metabolic syndrome, cardiovascular disease, stroke, dementia, Alzheimer’s, and higher all‑cause mortality. Dr. Perlmutter explains how modern diets (sodas, fruit juices, processed foods with hidden fructose, excess salt) and conditions such as sleep apnea increase uric acid production. He outlines how to test uric acid at home, the optimal target (<5.5 mg/dL), and cites large Japanese cohort studies showing risk percentages for various outcomes. Practical interventions are discussed: limiting high‑fructose foods, adopting time‑restricted eating, reducing salt, and using supplements that inhibit xanthine oxidase—quercetin (500 mg/day), luteolin (100 mg/day), and DHA (omega‑3). He also shares his personal routine (late first meal, two‑meal day, morning exercise, avocado with olive oil, fiber‑rich vegetables, fish, occasional grass‑fed beef) and monitoring tools (continuous glucose monitor, Oura ring). The episode concludes with a call to action to read Drop Acid (dropacidbook.com) and implement a simple step toward lower uric acid.

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