John OsborneChief Medical Officer, ClearCardio LLC · Preventive cardiologist and Chief Medical Officer at ClearCardio

Why Women Get HEART ATTACKS Later Than Men

22 Aug 2026 · 1 min

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In this segment, the speaker explains that men tend to experience heart attacks and strokes at younger ages than women, attributing the difference primarily to hormonal factors. Estrogen and progesterone are highlighted as potentially protective hormones for women, offering cardiovascular benefits that delay disease onset. The speaker notes that the incidence of heart disease in men typically rises in the early to mid‑50s, whereas women’s risk curves rise about ten years later, around their early to mid‑60s. While hormones are emphasized, the speaker also acknowledges that the overall picture is complex and may involve additional factors beyond estrogen and progesterone.

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Why might men have heart attacks and strokes younger? Well, we believe, I think it's a complicated story, but we believe that, yeah, I mean, men and women are different, right? Hormones and hormonal processes are obviously quite different. So we believe that probably because of the effects of estrogen and progesterone, and maybe other factors too, but that's an easy thing to differentiate this, that those can be beneficial to women. But interestingly, so it really— the curves for heart disease really start going up in early to mid-50s for guys, right? For women, they catch up though, 10 years later.