1:05:01

In this hour‑long podcast, host Jorge Cruise interviews Dr. Jason Fung, a nephrologist and author of The Obesity Code, to dismantle the conventional "calories‑in, calories‑out" model of weight loss. Dr. Fung argues that body weight is regulated by a hormonal thermostat, primarily driven by insulin. He explains that high‑insulin states—caused by refined carbohydrates, sugary drinks, and frequent eating—force the body to store excess calories as fat and suppress fat burning, leading to increased hunger and weight gain. The conversation covers the physiological basis of this insulin‑driven thermostat, using analogies such as a room’s heating system, and critiques the historical low‑fat, calorie‑counting era. Practical solutions are presented: intermittent fasting and reducing refined carbs (or choosing low‑glycemic, minimally processed carbs) to lower insulin and unlock stored fat. Dr. Fung also discusses the role of other hormones (cortisol, GLP‑1, sympathetic tone) and the impact of GLP‑1 drugs like Ozempic, noting they lower the thermostat but are not magic bullets. They address common concerns about fasting—muscle loss, autophagy, hunger, and optimal meal timing (e.g., one‑meal‑a‑day in the early afternoon). Jorge mentions his own “Zero Hunger Water” project as a non‑caloric appetite‑suppressing aid. The episode concludes with recommendations for listeners, book suggestions, and contact information for Dr. Fung’s online resources.

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