40:02

In this premium episode of the Living to 100 Club podcast, host Joseph Casciani interviews Nicole Laurent, a licensed mental‑health counselor and certified nutrition‑integrative health practitioner. Laurent recounts her own experience of severe cognitive impairment after chronic pain medication detox, describing symptoms that met criteria for early‑stage Alzheimer’s. She discovered ketogenic nutrition through podcasts, implemented a low‑carbohydrate, high‑fat diet, and recovered her cognitive function, noting additional anti‑anxiety benefits. The conversation then shifts to the science behind brain hypometabolism, insulin resistance, and how ketone bodies (especially beta‑hydroxybutyrate) can bypass defective glucose pathways to fuel neurons, act as molecular signaling agents, up‑regulate endogenous glutathione, and modulate inflammatory gene expression. Laurent explains practical ketogenic protocols for brain health—restricting carbs to 20‑30 g/day (≈5 % of calories), using healthy monounsaturated and polyunsaturated fats, liberal protein for older adults, and employing a modified Atkins approach. She highlights the diet’s historic use for epilepsy, its emerging evidence in metabolic psychiatry (schizophrenia, bipolar disorder, treatment‑resistant depression) with ongoing pilot studies and RCTs funded by the Bazooki Brain Research Fund. Safety is addressed: nutritional ketosis is distinct from diabetic ketoacidosis; patients on any medication must coordinate with a knowledgeable prescriber, and electrolyte management is essential during the transition. Laurent stresses the unique biomarker advantage of ketosis (urine strips, blood ketone meters like Keto‑Mojo) for monitoring compliance. The episode concludes with actionable resources—her online program, a free brain‑nutrition guide, and contact information (nicole@mentalhealthketo.com, brainfogrecoveryprogram.com)—and a call for broader clinician education on metabolic therapies.

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