0:32

In this segment, Dr. Afton L. Hassett explains the fundamentals of acute pain. She describes how pain originates from peripheral sources—such as tissue damage from a twisted ankle, surgical incisions, or inflammatory conditions like rheumatoid arthritis—where specialized nociceptors generate pain signals. These signals travel to the brain, which then interprets and perceives the pain. The explanation sets the stage for understanding how the brain processes pain signals, a key theme of the broader interview on chronic pain and its neural mechanisms.

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