38:21

In this episode of the Living to 100 Club Podcast, host Dr. Joseph Casciani interviews Dr. Jenny Leduc and Dr. Thomas Andriachi, co‑creators of Nemo, a smart knee wearable that uses motion‑timed vibration to reduce pain and improve quadriceps function. The conversation begins with the guests’ professional backgrounds—Dr. Andriachi’s 50‑year career bridging mechanical engineering and orthopedics, and Dr. Leduc’s biomechanics research and clinical‑trial experience. They discuss the massive global burden of knee osteoarthritis (≈375 million affected), its typical onset in the 50s, and how pain leads to quadriceps inhibition, shorter stride length, and a vicious cycle of inactivity and joint degeneration. Nemo’s technology is explained through the Gate Control Theory of pain: timed vibration delivers non‑painful sensory input that “gates” pain signals while simultaneously stimulating quadriceps activation during walking. Compared with traditional knee braces, which restrict motion, Nemo encourages movement, aiming to keep users active. The hosts review two clinical studies—a 21‑person single‑day trial and a 38‑person month‑long crossover trial—showing significant pain reduction, improved quadriceps use, and higher activity levels, with participants using the device an average of three hours per day. Target users include people with chronic knee pain from osteoarthritis, prior ACL or meniscus injuries, post‑total knee replacement, and even young athletes such as ultra‑long‑distance runners. Nemo can be used independently or alongside physical therapy, and it provides remote usage data to clinicians. Pricing is a $499 one‑time, non‑prescription purchase (FSA/HSA eligible), with plans to seek insurance reimbursement. The discussion ends with broader implications for longevity, workplace health, and the importance of staying active for overall well‑being.

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