44:34

In this episode of the Living to 100 Club, host Dr. Joseph Casciani interviews award‑winning urologist and sexual‑medicine pioneer Dr. Judson Brandeis. The conversation begins with Dr. Brandeis’s extensive background—training at Brown, Vanderbilt, Harvard, and UCLA, early work in surgical robotics, and recent focus on regenerative urology (shockwave therapy, platelet‑rich plasma, stem‑cell injections). He describes a holistic, Maslow‑pyramid model for men over 50 that places physical health, emotional health, relationship communication, and sexual health as sequential foundations for satisfying intimacy. The discussion moves into specific clinical topics: the prevalence of erectile dysfunction (ED) by decade, the physiology of penile blood flow, and how to improve it with nitric‑oxide boosters (Affirm) and daily PDE5 inhibitors (tadalafil). Dr. Brandeis explains his "Male Rejuvenation Protocol," emphasizing testosterone monitoring, muscle‑mass preservation, and combating sarcopenia through nutrition, protein absorption, inflammation control, and high‑intensity focused electromagnetic (HIFEM) therapy. He outlines his research studies (Mensella 2, IA Strong) and the role of supplements such as Spunk for prostate health. Prostate enlargement is broken down into symptom categories (obstructive vs. irritative) and a tiered treatment ladder—from beta‑sitosterol‑based supplements to alpha‑blockers, 5‑alpha‑reductase inhibitors, and office‑based or surgical interventions (Rezūm, Urolift, Aquablation). Dr. Brandeis stresses the importance of patient preparation for medical visits: a comprehensive written health history, medication list, recent labs and imaging, and a prioritized question list to maximize limited appointment time. The conversation also covers the partner’s role, especially post‑menopausal changes, recommending estrogen therapy or silicone‑based lubricants, and encouraging couples to explore intimacy beyond penetrative erections. Dr. Brandeis promotes his 900‑page book, The 21st Century Man, which compiles expert chapters on every organ system, lifestyle, and longevity strategy. He concludes with a call to focus on healthspan versus lifespan, using the book as a practical roadmap. Key takeaways include: adopt a holistic health hierarchy, address vascular and hormonal factors early, use evidence‑based regenerative therapies, prepare meticulously for doctor visits, and involve the partner in sexual health planning.

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