Joseph CascianiGeropsychologist, Consultant, Public Speaking, Freelance · Podcast Host of the Living to 100 Club | Clinical Strategies for Senior Residential Settings & Lifestyle Directors | Geropsychologist | Keynote Speaker

Understanding Hormone Replacement Therapy with Greg Brannon

25 Mar 2024 · 1 min

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In this interview segment, Greg Brannon (Speaker A) challenges the common acceptance that testosterone loss is an inevitable part of aging. He argues that testosterone, the most abundant hormone in the body, is being lost at an accelerated rate because estrogen—derived from testosterone—provides a feedback loop that regulates testosterone production. Over the past 50 years, widespread environmental exposure to synthetic or “xeno” estrogens has disrupted this feedback mechanism, hastening hormone decline. Brannon links this rapid hormone loss to several age‑related conditions, including osteoporosis, dementia, and sarcopenia. He also mentions his forthcoming book, Restore, which will elaborate on these ideas and propose strategies for preserving hormonal health.

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the hormone our body makes at physiological optimal levels. Joe, the big thing I use— I got a new book coming out, Restore, comes out next month— is like, we would never say it's okay to lose insulin as we age. We'd never say it's okay to lose cortisol as we age, but it's okay to lose testosterone, the most abundant hormone in the human body? I disagree. We're losing at a much faster rate because in our body estrogen comes from testosterone. Estrogen is what feedbacks loop to produce the production of testosterone. And last 50 years, we've been bombarded in the environment with these xeno or fake estrogens. That's speeding up the process of rapid hormone loss, and therefore, i.e., aging processes, osteoporosis, dementia, sarcopenia, things like that.