Short YouTube clip (Joy Kong, MD) discussing risks of receiving very large quantities of stem cells (e.g., 200–300 million). Dr. Kong explains that many cells in very large doses may no longer be true stem cells, have differentiated and express proteins encoded by donor DNA, and that DNA/protein differences can trigger immune activation and rejection, leading to people feeling sick.
I always hear people touting the numbers, like, oh, you're gonna get a hundred million stem cells. No, I'm gonna give you 900 million stem cells. Does it matter?
That's what I see in patients who go overseas, getting this huge number of cells, 200 million, 300 million, and they think that's better. Well, if you're getting 200, 300, most of them are not stem cells anymore. You're gonna have more chance of rejection because these cells have basically manifested more of its own characteristics, its own proteins. The proteins are an expression of your DNA. So whatever the strand of DNA is encoding, that's the protein that's going to make. And your DNA is different from someone else's DNA. And that slight variation could trigger your immune system to attack it. So now you've got this, this immune activation and this rejection. So there's way more issues of people feeling sick.
