By how much did the speaker say collagenase can increase cell yield from the same tissue?

Joy Kong, MDRegenerative Medicine Physician, Educator, and Entrepreneur

STEM CELL therapy in the US vs. overseas [MUST WATCH]⚠️ #stemcelltherapy #shorts

18 Mar 2023 · 1 min

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Joy Kong, MD explains why stem cell therapy differs across borders. The US FDA restricts collagenase digestion and cell expansion because they view these processes as altering cells, while overseas clinics use them freely. Collagenase can yield roughly 10 times more cells, but expansion may change how cells behave and trigger adverse reactions.

Questions this video answers

About 10 times as many cells.

Chapters

If you have put the cells into incubator and you grow them into a large number, there could be changes that happen to those cells. Or if you use enzyme because they can get your fat and they will try to digest the connective tissue that's blocking the stem cells. So you put collagenase to break down the collagen. All of a sudden you're freeing up all these cells. You can get 10 times as many cells from the same tissue. But the problem is the FDA says, well, if you use collagenase, that means that you. There's a potential that you're altering the cells, which is from the birth tissue is completely unaltered. That's why all these companies decide to go overseas which where they don't have the same kind of restrictions. So what they do is that they will take the cells and then they separate the cells out and they put them in the incubator and grow the cells to huge numbers. By the end, you have way more daughter cells than original stem cells. But they're more differentiated, which means that they express more surface receptors and there's more potential to cause adverse reaction.