Interstitial Cystitis, UTIs and the Gut–Bladder Axis with Aleece Fosnight, MSPAS, PA-C

3 Feb 2026 · 67 min
The Perfect Stool Understanding and Healing the Gut Microbiome

3 Feb 2026 · 67 min

0:00

In this episode of The Perfect Stool, host Lindsey Parsons interviews physician assistant Aleece Fosnight, a specialist in sexual medicine, women's health, and urology. The conversation covers the complex nature of interstitial cystitis/bladder pain syndrome, its various subtypes (GAG‑layer breakdown, pelvic‑floor dysfunction, nerve injury, Hunter’s ulcers, mast‑cell/histamine involvement) and how these can be misdiagnosed. They explore the gut‑bladder‑vaginal microbiome axis, emphasizing that dysbiosis in the gut or vagina can influence bladder health. Diagnostic tools such as standard urine cultures, extended‑culture MicrogenDX sequencing, and biofilm awareness are discussed, along with the most common uropathogens (E. coli, Klebsiella, Enterococcus, Proteus) and less common organisms (mycoplasma, ureaplasma, Corynebacterium urealyticum, etc.). The role of pelvic‑floor anatomy and dysfunction (high‑tone vs. low‑tone, assessment, therapy, Kegels, hypopressive exercises) is explained, with guidance on finding qualified pelvic‑floor therapists. Vaginal microbiome health, probiotic options (oral vs. vaginal, Seed), and adjuncts such as boric acid or vitamin C suppositories are reviewed. Lifestyle factors—fiber, hydration, diet, cranberry pro‑anthocyanidins, and bladder‑training techniques—are presented as preventive measures. Hormonal changes in menopause and the use of local estrogen or DHEA therapy to reduce recurrent UTIs are highlighted. Finally, they outline referral thresholds (≥2 UTIs within 3‑4 months, ≥3 per year, hematuria) and stress a root‑cause, patient‑centered approach rather than band‑aid treatment. Promotional segments for Lindsey’s gut‑health coaching and supplements are interspersed but are not core clinical content.

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