Michael ZellerNeurorewired LLC · Neurorewiring Expert

Serotonin, dopamine, oxytocin — all at the same time

15 Aug 2026 · 1 min

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In this brief segment, the speaker explains what MDMA feels like as it begins to take effect during a guided session. He likens the onset to a warm blanket wrapping around the body, describing an enveloping, comforting sensation. He outlines the neurochemical cascade—serotonin, dopamine, norepinephrine, and oxytocin—that is released, and explains how this biochemical surge enables the mind to let go, fostering openness, self‑empathy, and reduced reactivity. The speaker emphasizes that the flood of feel‑good chemicals allows individuals to engage in compassionate self‑inquiry with fewer triggers.

Chapters

So what does MDMA feel like as it kicks in in an MDMA guided experience or session? Well, it's almost like a warm blanket wrapping you around because of all the neurochemical cocktails that are released. Think of it as releasing serotonin, dopamine, norepinephrine, and oxytocin. Now your mind is able to let go and you're able to sink in and allow your heart and your body to speak. MDMA makes you more open to self-empathy and self-inquiry, where you're able to see yourself with more compassion because now you're flooded with these feel-good chemicals and now you're not going to be triggered as much.