Mona SharmaCelebrity nutritionist and wellness advocate

Dr. James DiNicolantonio | Rooted in Wellness #shorts #youtubeshorts #health #guthealth #wellness

24 Dec 2024 · 0 min

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In this short interview, Mona Sharma asks Dr. James DiNicolantonio how consuming large amounts of ultra‑refined, heated seed oils contributes to inflammation. Dr. DiNicolantonio explains that inflammation is driven by oxidized linoleic‑acid metabolites, which activate tumor necrosis factor‑alpha (TNF‑α) and nuclear factor‑kappa‑B (NF‑κB), stimulating immune cells in a harmful way. He links these biochemical reactions to the oxidative stress that accumulates over time from regular seed‑oil consumption, leading to elevated inflammatory markers. The conversation concludes with a strong recommendation to prioritize eliminating seed oils from the diet to reduce this oxidative burden and associated inflammation.

The direct correlation. If I'm consuming a lot of seed oils, processed ultra refined heated seed oils, how is that contributing to their inflammation?
What is inflammation? It's partly these oxidized linoleic acid metabolites, but also it activates tumor necrosis factor alpha, nuclear factor kappa beta. It stimulates immune cells in a bad way. And that's what really inflammation is, is those types of things. And that's what seed oils do, and that's what actually inflammation is.
So it's so important to like really prioritize eliminating these from your diet, because it's almost like the accumulation of this oxidative stress over time is eventually what leads to those inflammatory markers that you talked about.