Paul Savage MD explains why some women can't tolerate bioidentical progesterone despite its benefits for anxiety, mood, and sleep. High toxic burden blocks progesterone from binding its receptors. Therapeutic plasma exchange removes circulating toxins, freeing up receptor sites so progesterone can work.
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For instance, you'll have a lady who wants to take bioidentical progesterone, which is something the body made. It's essential to help with anxiety, mood, sleep. It's anti inflammatory, protects the brain. It has so many benefits. But we get ladies that are so toxic, sometimes we try to give them a dose that's traditionally what you should take. They get sick and nauseated, it makes them feel a million times worse. So we'll get asked, can you make a lower dose? Can you make a lower dose? So we keep going down and down to the point like you really can't make it any smaller and they still can't tolerate it. Well, that's where this, that's where this TPE comes in, is we remove the toxins. And now that lady who couldn't take hormones because they, they, they battled for the same receptor site, now that progesterone can sit on that receptor like it's supposed to not compete with this toxin and the, and she gets all the benefit. And that's the kind of stuff that I really feel like opens the door what TPE can do.