Why Are Healthy People Still Getting Heart Disease with Dr. Paul Anderson | TPE Blueprint #20

Have you ever wondered why some perfectly healthy people still end up with heart disease? Today's guest. I'm having him back for round two. His name is Dr. Paul Anderson. He's an expert on environmental toxicity and innovative cardiac care. He's here to reveal how therapeutic plasma exchange, tpe, and advanced testing are totally rewriting the rules of cardiovascular prevention. Let's dive into it.

All right. Dr. Paul Anderson, thank you for joining me. Round two. How are you doing today?

Doing great. Thanks for having me again, of course.

Yeah. Well, I mean, you're very fascinating. I know you've. What. Dr. Savage was hanging out with you at your event recently, and, you know, it's. I. I enjoyed our conversation talking about cellular level, like, all just getting really into the. The mitochondria and the very little bits that make up everything, you know. So, yeah, definitely go back and watch those or listen to those. Y'.

All.

If you haven't met. Met Dr. Anderson yet, this time around, we're gonna go down the rabbit hole when it comes to heart health and how that kind of pairs up with TPE therapy to plasma exchange and. And probably a lot of other things that I'm yet to discover from you. So where would. Yeah, where would you normally, I guess, start the conversation? You know, you just had a whole event.

We had, of course, different speakers speaking about, you know, different aspects of. Especially prevention of cardiovascular disease, but also treatment, you know, along the lines of what can we do beyond the standard drug therapies, for example. And so one of the areas that I really delved into to try and do some pretty deep presentations on was the crossover between environmental exposures and environmental toxicity and then various types of cardiovascular disease. And in regard to what we want to talk about today, I think those. Those are the areas I was most excited about kind of getting back into after spending a lot of time looking at different research that's been done and things that have, you know, maybe we didn't know or we didn't know really well 10, 15, 20 years ago, we know a lot more mechanically about. But it turns out that there is a huge crossover in increased risk for almost all types of cardiovascular disease that, you know, we commonly see anyway, things like hypertension and hyperlipidemia and other, you know, cardioinflammatory processes. There's a huge crossover between those and increased risk with increased toxicity, exposure. So I thought that was a really great place probably for us to kick off.

Absolutely. Well. And, yeah, we could kick off there. And also, I'm curious about any new Research or at least big things that we as probably those that aren't so in the cardiovascular space all the time, like what should we be looking at.

Or knowing if we take the last 10, 15 years of diagnostic capability.

Certainly there have been, you know, a lot of more, you know, beyond the standard, you could say, diagnostic capabilities for quite a long time. But I think if we look at the technology available for your, you know, more standard blood tests and then some of the, you know, added risk factor blood tests that we have, we're in a better place than we've ever been to really predict whether or not your risk factors are really increased compared to, you know, the rest of the population that you live in. And, you know, certainly there's always those outliers where they may have no risk factors and they still have disease, or there's the other people that have all sorts of risk factors and they never seem to have any problems. But, you know, most of the people, it really does follow that if you're having increased amounts of inflammation, inflammatory, triggered, you know, cardiovascular findings on your labs, increased amounts of maybe genetically triggered cardiovascular findings in your labs and things, your, your risk does really correlate to that. And I think we're maybe, it's almost sometimes we feel like we have too much information in some cases. But I think we're at a really good place for. We can look at you biologically and biochemically and then say, okay, you know, is there a piece of this that's maybe genetic, but what can we do to modify those things? And then, you know, what I really saw in working with these other specialists and presenting more along the idea of toxicity and inflammation was that is as important of an area to handle in cardiovascular risk as your diet, which is super important, and exercise. You know, all the things that we think about and we don't often think as much about toxicity or environmental impact and it's, it's a huge, huge risk factor that's modifiable.

Well, yeah, let's, I guess let's talk about that and how you see the importance of that crossover. Because it's not, it's not this or that, it's. It's an answer. Right?

Yeah. And I think with environmental factors there's a number of ways to look at it. So one thing is you might start out and you've maybe you have some family history of cardiac problems or you don't have any family history, but you get all checked out and your provider says, well, you know, these, these markers are high and they shouldn't be or these are low and that shouldn't be, you know, here's the things that we can do about it. Normally there'll be a recommendation maybe for a pharmaceutical intervention.

Most of the time at least there should be a recommendation around your diet and potentially exercise. So those are kind of your common areas of intervention. And then people will sometimes look at.

The genetic part of it because there are things that we do inherit and they'll sort of skip over the part that we can modify some of the genetic that we do inheritance. So for example, while genetics are, are the code sort of like the recipe, your epigenetic signature is what, what turns the code on and off and all those. Well, that's one huge area where environmental toxicity can kind of plug in. Is one of the big triggers for an epigenetic turn on of maybe some bad genetics. And all of that is, is being triggered by toxicity and environmental exposures. And then the other thing which I, I knew was kind of in the research, but when, until I was preparing some of the toxins, realized how much is beyond those, you know, maybe the, your genes get sort of bruised up by the environment you're in and the toxins. Beyond that, the number of diseases and disorders in the cardiovascular system that are directly connected to higher levels of toxicity, giving us higher levels of, you know, cardiac disorders and disease. I think that's an area that's largely overlooked because up until now, maybe it was a little hard to figure that out. Maybe the data about it wasn't as clear and compelling as it is now. And then I think that, you know, even to the point of what we talked about last time, the ability to do anything about some of the toxicities has really been, you know, kind of a big question mark in medicine, I think. And so that's why. And we had Dr. Savage there, he did a presentation and kind of went through the very ultra specifics of TPE cardiac crossover. So I think now we have more interventions that make sense and that we know more scientifically about. So that's, I think that's a, that's a real positive thing.

It's. It is, yeah. The fact that we have the ability to do these modifications or, or somehow intervene in new ways. And like you said, it's. And just like Dr. Savage, you know, it starts with the data. So there's better testing, more testing. Right. With blood testing, genetic testing. And it sounds like, yeah, with. It's interesting that the genes, yeah, they, they are modified and like you said, they get bruised up so by toxins. Or outside influence, they're changing these genetics that might not have been turned on.

Right.

Otherwise.

Right, yeah. Or enhancing, you know, because we, the, the thing with the way our, our genes work in some places, so some people say, well, you know, what if you have a inborn, you know, cardiovascular, you know, plumbing problem that you inherit, that's sort of a different type of genetic problem.

Got it.

But your genetics, that might be encoded for how much LDL you make or how much inflammatory chemicals you make or other things, those can be very directly, either up or down, regulated by how much toxin, another epigenetic trigger is there. And so there's ways to say, yeah, you know, you're going to have a harder time if you, if you carry these genes into it, but you don't have to pour fuel in the fire, you know, and, and make it worse by keeping toxicity and toxicants around. And, you know, another really interesting thing is genes. A lot of what genes encode for are enzymes that help us to do, you know, make products in the body and, and go through, you know, biochemical processes and pathways. It turns out in some of the. More you maybe just say negative things that we don't want to make biochemically that for our cardiovascular system, a lot of them are directly turned on by extra toxicity, especially chemical toxins and things like that. And so the more of those you have, it's like, well, you could have the most perfect genes for all those enzymes, but if the chemical toxins turn them on so they all go into the direction of, you know, inflammatory mediators and things we don't want, that's something we could remove or lower in the person and actually change the outcome.

That's interesting.

Yeah.

Well, it seems like with, I mean, I guess, what's your take on this? Like a general, you know, most of the doctors that are looking at people with heart condition or maybe just testing for hearts, like, are there. Is this overlooked right now, you know, the fact of how toxins are playing this key role?

Oh, 100%. Yeah. It's, you know, it's one of those things where we wouldn't be having people writing, you know, research papers and doing research about it if it wasn't known about on one hand. But does that mean that it's worked its way into the way clinical medicine deals with these things most of the time? No, no. Environmental toxicity is still sort of this, you know, blind spot, I think, clinically for not everybody, obviously, but for the majority of people. So if you go into your doctor and you've got you know, some out of, out of balance cholesterol, things going on and some family risk. They're going to focus more on, well, you know, would a statin be right for you or this other drug? They're probably going to talk to you about changing what you eat, maybe talk to you about exercise. But when it comes to things like environmental exposure and toxicity, that's not a part of the way most medicine is practiced right now. So. And they might even know it's a possibility, but they don't have any way to treat it, so it kind of gets overlooked. Yeah, yeah.

Because, yeah, you mentioned statins and, and you know, the, the, the typical treat. Yeah. Exercise, diet, which is, you know, makes sense. But you're right, it's kind of overlooking the other factor that could be kind of completely changing the whole game.

Yeah, yeah. And it, you know, and I think like you said earlier, it's not either or it's just if we, you know, if we have three areas we're affecting usually with our patients, and there's a fourth or fifth area that we could add in, you know, that would be a really wonderful thing because it makes all the other stuff work better.

That's right. One, like a, I'm thinking of the, like our last chat about cellular health and all that. Are there, are there any obvious changes that happen that precede a serious heart event or some, some heart issues that maybe we can kind of be aware of or notice ahead of time?

Yes. The big picture answer is yes. Some of them we can kind of see either the, the cause or maybe the effect of in laboratory testing. You know, you always hope that you find these things before you have some cardiac event that, you know, then they're working backwards. So the normal testing that is done, say with your cholesterol, for example, and triglycerides and maybe some of your blood sugar things. Those are looking at this mixture of how your genetics are set up to make these things in our body and then how our body interacts with our genetics through the, the diet that we eat and how much movement we have and, you know, all of the things that go into making these things. And so our, our markers that we look at can be some of the first things before we have a problem to say, well, these patterns in your, your LDL and your hdl or maybe these patterns in your.

Inflammatory markers that directly affect your cardiac system, those are things that need to be looked at and then we are going to stratify your risk based on that. So that's kind of the first layer, then more and more clinicians are using some of what I consider the next layer of testing where they might actually break down, you know, the, the LDL into. There's. There's like better and worse ldl. And so they might do that test. And that's very helpful. Yeah, there's some other markers that are very, very predictive of future problems that we don't normally add into the regular pal. It might be doing that.

And, and then there's sort of a third layer where there's a lot of these kind of. Okay, the biochemistry can either be in a less inflammatory mood or more inflammatory mood. And we look at, you know, these markers that come out the other side that show, oh, you're, you're processing these chemicals that affect your cells in an okay way, or you're processing them in a way that's very inflammatory and we should not have that going on. So I think that's one thing. And then on the other side, and it's in an evolving science, but when you get to the environmental effects, you have all sorts of different types of environmental toxins that you can look at. Metals are fairly easy to test. Some of the biological toxins or biotoxins, like mycotoxin for mold is getting, we're getting better at testing that. Chemicals can be tested much easier than 10 or 20 years ago, you know, so there again, if you have a person who's really high risk.

And those other things aren't being looked at, it really does round out the assessment of that person.

Hello, my name is Carrie Stewart, and I did the brain protocol for the MD lifespan. I was struggling to recall names, couples. And so I shared this with the doctor. That's when he introduced me and said, I think you're ready. And let me explain to you a tpe, because this is going to help your memory, your focus, your clarity, and I truly believe you'll be a wonderful candidate for this. I have had five TPE protocols, and each time I have improved. And it's not until this last one that I honestly, I am feeling so back on top of my game. Like my brain fog is gone. I am focused more. I have more clarity. This was life changing for me and I feel so much better for it.

I mean, this kind of leads to TPE and how. I'm just curious of how you're thinking with the use of therapeutic plasma exchange and what you're doing here with the cardio side and some of these traditional, I guess, what does that crossover look like? And we can Kind of drill into some of those points.

Yeah, I think, you know, if we look at the way that TPE works, where you're essentially removing large amounts of proteins that we've made that are, you know, floating around in our blood and temporarily replacing them with a pure albumin product and then obviously some other nutrients and fluids and things. The idea there is, is that you have this constant movement from your, mostly your liver, a little bit your bone marrow and other places where you're going to make these proteins and then they're going to do their normal job, which is planning. Plasma proteins do, do all sorts of biochemical things, but they also are going to hold on to things. They're very sticky, so they're going to hold on to toxins. All metals can be on there, chemicals, mycotoxins and stuff. So if, if we go through and as part of what we're doing, we do a TPE procedure, then all of that.

You know, mess of chemistry that was bound to your proteins leave you and then you give your body a little bit of time, it recovers, it pushes a little bit more out and then you do procedure again and then that leaves. And so it's sort of a way to, almost irrespective of the type of toxin, it's a way to, to in a sense use your natural plasma proteins as a way to mop up the toxicity and move them out. And then what, what really happens is then the less you have immediately available in your liver, then the more as those plasma proteins circulate around, they might pick up toxicity from your cell membranes or, you know, other peripheral places. So it's, it's really like, you know, if you take.

You drain a swimming pool that's, you know, full of algae or something, if you drain it the first time, but you don't really clean out, you know, the walls and all of that, drain it again, you're going to get cleaner water each time. But until you get down to that base layer and you have less of the algae floating around, you're not really going to get nice, you know, clean water. So.

Good analogy.

And it's, yeah, you're, you're just, it's not like any human can ever be, you know, completely toxic or completely non toxic. But the idea is let's take some of the stress off the body. And this is, you know, I've done lots of other types of detoxification with people and they're very effective for different things at different times. Whether it's sweating or, you know, chelation, therapies or other, you know, detoxification therapies. This gets at it from a completely different mechanistic point of view. So it's, it's almost like trying to reset the system and go from like lots of toxic exposure to a very low amount and then your body can naturally do its job better.

Right. Well, it gets back to what we talked about last time, which is take the stress of all the mitochondria. Right. And.

It'S reducing inflammation, reducing oxidative stress. Right. And TPE and this plasma exchange is, I'm assuming within support other heart protocols or just in general. Yeah. The practice of like diet now.

Yeah, it's, it's, it's a way to clean the system up so that then whatever else you're doing isn't fighting so hard against a system that's, you know, bogged down by toxicity, etc.

Are you seeing people starting to take this approach with, with this specific in mind? Like, is it, I guess, what's the timing that you see it used often? Yeah.

In the TPE right now, en masse in medicine, it's not thought of a lot, you know, for prevention because normally TP procedure is used for certain types of autoimmune or rheumatologic diseases or drug toxicities or, you know, emergency type things. Things. But what I have noticed just in the last three or four years of observing clinical medicine in places where they're more likely to be open to new ideas is there's a lot more discussion of and use of TPE by what I would consider forward looking clinicians who are, you know, looking to give the body every opportunity possible, you know, to have the least amount of interference, essentially. Yeah. So I see it, you know, if we look at those who probably would be more likely to be doing this and using tpe.

Whereas three, four, five years ago, I might have heard one or two doctors or centers talking about it rarely. Now it's much, much more common, you know, in that community to say either they're looking for a place to do it or they're doing it themselves or, you know, something like that. So I think that's a good sign that it's, it's catching on that we don't need to just use this for, you know, big bad autoimmune diseases and, and toxicities from drugs. We can use the same technology for prevention.

Yeah. And it seems like, I'm sure, education. I mean, you're a big educator on YouTube and you know, you, you put a lot of work out there. Your Books. Books. Plural. Books. Right. I believe.

Yeah.

Yeah, so. And maybe that's the case here. I mean, that's. That's what we're trying to do with TPE on this podcast, of course, is just.

Yeah.

Bring it to the world in different ways. And ideally, maybe it's, you know, when someone's told, hey, you're a heart attack waiting to happen, or some other way, there's a. There's an approach that's a little bit, you know, it's a little bit better there, maybe, maybe even quicker than, hey, just. Just eat a little cleaner.

Yeah. Speaking of that, you know, as far as there. There's some very AI interfacing testing that we can do now that really we couldn't do before, that actually can look at some of the more soft, literally soft markers of vascular damage and things like that, where in the past we might have to wait and you get maybe a high calcium score, and that doesn't associate with, you know, very good things. But you couldn't tell from that whether is it the better or worse kind of high calcium score, you know, or what's going on inside the vessels. Now we can actually see using sort of an AI interface with that technology and others. Oh, you know, you're literally a cardiac event waiting to happen. But we're seeing it way earlier. Oh, that would be, you know, one of the many times where I would say I wouldn't just, you know, I. I would do all the normal stuff, I would change my diet and do all things, but I wouldn't wait around, you know, to become a worse, you know, a worst candidate. And, and so doing something like a series of TPE to also kind of clear the decks from a toxic inflammatory point of view really makes a lot of sense there. You know, I mean, the ideal would be don't wait till you're, you know, about to have a problem or you've had a problem. But now that we get. We have a lot more earlier warning sort of testing we can do, I think, you know, certainly if I saw that or if I see that in patients, it'd be like, yeah, there's all the normal stuff, but there's this whole area of toxic inflammatory load that those treatments don't really get to. And if we can do this with you, it takes another big brick off the pile, you know, as far as risk factor. Yeah, right.

And that's, that's why I love, you know, the way you break this down and how it goes all the way to the mitochondrial level and it's like, yeah, if it's, you know, it's. If it's bringing in all the. The gunk, it's like the cool analogy. It's like, how do you. How do you think your body's going to function? And then you layer in genes and all these different factors that we individually hold. At least now we know testing can help us identify this. But we also have things like TPE to help actually clean it in a mechanistic way than the other ways, definitely, I guess. And to wrap it up here, what's exciting, I guess what excites you the most with what you said? Testing has been coming around. You mentioned AI. We're talking about TPE is, you know, or maybe a combination of this, like, where do you see things go in the next five, 10 years that excites.

You as specific to the cardiovascular risk in a person? We are at a better place than any time in the past to be able to see big trouble before you have a heart attack or a stroke or, you know, some other event that you don't want to have. So I think between better lab markers, better imaging of the actual cardiovascular system, you know, that uses AI to inform it so we actually know what's going on. I think if we put all those together on the diagnostic side, we can intervene in people long before, hopefully, they have any problem, you know, and have the need to do, you know, everything that they possibly can. So I think if you take that on the cardiovascular side, plus our ability to more effectively test for all of the toxins and toxicants that go on, and we're all exposed to so many of them, it's not, you know, it's not like we're not going to have them, but some people are really, really full of them for various reasons. So if we see we've got two big risk factors before you have a problem, we could kind of pull out all the stops. We do the dietary stuff. We do maybe nutraceutical interventions or drugs or whatever. But also you could do TPE to kind of take care of all of the chemistry stuff that, you know, a drug's not going to fix and nutraceuticals aren't going to do that much for. And your diet change will help, but it's not going to take care of the toxicity. So I think it's a nice kind of collusion of new technologies that can help both on, let's find your problem before it's a problem, and then let's treat your problem before it's a problem.

I would I would add a third on. There is like the education layer. So, like, you know, there's. Yeah, there's a lot of media now coming around this and.

Yeah, a lot of, A lot of clinicians really, and, and many, many patients, of course, don't even realize there's been these changes or that these things are available. And so I think that's, you know, the education side is. It's a huge need.

It is. And that's, that's, that was. That's the key thing I keep thinking of with this podcast and show. It's not just general population, it's. It's people actually in the trenches, people working on this every day. But, you know, everyone's so focused or busy or they're just trying to stay with what's happening now.

Yeah.

So, yeah, I think things are moving fast. Well, Dr. Yansen, I appreciate you. Where is the best place people can go to deep dive into your books? You know, YouTube, anything else you have out there?

I have a hub website that's got all the links on it. It's D R A N O W dranow.com and that has the YouTube links and the books and my professional websites and all. Pretty much everything there.

Yeah. Beautiful. You keep it easy. I like it. So we'll link it all in the show notes, description. Thank you. Appreciate your time so much again, Doctor.

Hey, thanks again.