The 5-Day Reset That Calms Cravings

29 Apr 2026 · 38 min
Episode

29 Apr 2026 · 38 min

0:00

In this episode of the Peptides and Longevity Podcast, host Michael interviews longevity dietitian Renee Fitton, director of education at L‑Nutra (the maker of ProLon). The conversation centers on the 5‑day ProLon fasting‑mimicking diet (FMD) as a practical, low‑stress longevity hack. They review clinical evidence (over 47 fasting‑mimicking trials, 25% skin‑hydration improvement, 2.5‑year biological‑age reversal after three cycles, 67% of type‑2 diabetics reducing or stopping medication after regular cycles) and explain the cellular mechanisms engaged by the protocol: down‑regulation of nutrient‑sensing pathways (mTOR, IGF‑1, PKA), up‑regulation of AMPK, ketone‑mediated epigenetic effects, activation of NAD+ and sirtuins, autophagy/mitophagy, stem‑cell activation, and reduced cellular senescence. They discuss metabolic benefits (blood‑sugar, A1C, weight loss, blood pressure, cholesterol), immune modulation (shifts in lymphoid/myeloid ratios), and behavioral outcomes (over 80% report reduced cravings and improved relationship with food). The hosts explore how oral peptide and bioregulator supplements from Integrative Peptides can amplify the fast – pineal‑activating peptides (Epithalon, Pineal Pep) to support telomere maintenance and melatonin, DNF‑10 “Can’t Wait” to blunt ghrelin/leptin signals, and the probiotic “Gut Feeling” (Arkmancia/Akkermansia) to improve gut barrier and stimulate endogenous GLP‑1. They also touch on low‑dose GLP‑1 alternatives, microbiome support, and practical guidance (3‑6 day fasts, 3‑4 cycles per year for most people, longer for metabolic disease). The episode ends with calls to action for ProLon, L‑Nutra health programs, and Renee’s contact information.

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