What percentage of chronic disease does the speaker claim is downstream from endotoxemia?

Josh TrentIdentity Transformation Architect and award winning Host of the Wellness + Wisdom Podcast—a decade-strong show with over 750 episodes and 15M downloads.

Why You Can't Meditate (It's Not Your Fault)

13 Nov 2025 · 1 min

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Speaker (Josh Trent) confesses to previously being a harsh teacher and doctor, then describes an empathic shift after recognizing that many students/patients who struggle to meditate may have underlying biological issues. He cites gut-related causes (torn gut lining, zonulin, leaky gut, dysbiotic bacteria) and asserts that “80, maybe 90% of chronic disease is downstream from endotoxemia,” using this to explain why people can’t relax or meditate despite appearing able to do so. The passage frames the speaker’s apology and change in perspective.

Questions this video answers

"80, maybe 90%" (as stated in the transcript)

Chapters

I will start with a confession that I come from a history of being a shitty teacher and a shitty doctor. Because of this very thing. People would come in and I would be on this side of that shame fence, being like, what do you mean? Like, you're not working hard enough. Like, you sit down and meditate. What's wrong with you? And then I, at one point was like, why am I getting pissed off at my student, my patient, whatever? And it led me down this real empathic path of just like, holy shit. You can't meditate because your gut lining is torn. Look at these zonulin levels. Like, let's just say you have a tear in your gut lining, you have leaky gut, and you have the wrong kind of bacteria. We now understand that 80, maybe 90% of chronic disease is downstream from endotoxemia, which means the bad guys are jumping the TSA line. The alarm bells are going, and you're sitting here thinking you're going on vacation to Hawaii, and this airport's on lockdown, of course you can't meditate. Shame on me for not listening to them in the first place.