YouTube video by Josh Trent about ketones, ketosis, and fasting. The clip discusses historical human fasting experiments (including seminary students fasted for ~90 days and a reported 365+ day fast), metabolic measurements (ketones, blood glucose, triglycerides), and the idea that ketones can replace glucose as a brain fuel during prolonged fasting. The content situates these findings against modern endurance beliefs about constant carbohydrate intake.
Chapters
So the ketone research, the story really starts with this Harvard Medical School professor who did the seminal study on fasting. So he would fast seminary students for 90 days. 90 days. One of the longest fasting experiments was like a 365 plus day fast. Were they overweight or. Yeah, this particular n equals 1 was like an overweight person. And this was like in the 60s and 70s. So the theology students were just fasting and you would get these very interesting ketone, blood glucose, triglyceride, all the substrates that power metabolism. Like, those were the seminal human studies. When you're just fasting these humans for, like, these long, extended durations. A lot of that early research saw that ketones were looking like a very good replacement for glucose. We don't just go brain dead when we run out of stored glucose or glycogen. I think there's like a lot of this common saying, especially in, like, the modern endurance world, hey, you gotta eat gels and sugar and all that stuff, or else are you gonna, like, carb load? Carb load. But it's obviously very clear that when we were hunter gatherers, we were not just constantly having sugar bomb in our pocket.