Wendie Trubow, MD, MBA, IFMCPPresident at Five Journeys, Functional Medicine & Wellness Provider, Best Selling Author, Passionate Champion for Health

Does a Higher Ketamine Dose Lead to Better Results

17 Nov 2025 · 0 min

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0:09

Short excerpt from a YouTube conversation about ketamine treatment expectations and dosing. The speakers discuss whether higher ketamine doses produce better outcomes, with Wendie Trubow responding that higher doses are not necessarily better. The clip frames common patient expectations and clinician pushback about dose size.

Are there any downsides for ketamine or things that are unrealistic expectations of the ketamine dosing or the experience?
I think in terms of dosing, it's interesting that many of the people that we see in Boulder, Colorado, people think that higher doses are better. You know, bigger is better.
Oh, it's not.
Obviously, ketamine at higher doses is an anesthetic and it does cause amnesia. So, you know, going into a so called K hole where you're sort of fully dissociated, I don't think it's necessary or more beneficial than dosing that allows people to be present and witness their experience and process it afterwards.