Wendie Trubow, MD, MBA, IFMCPPresident at Five Journeys, Functional Medicine & Wellness Provider, Best Selling Author, Passionate Champion for Health

How to Get Rid of Senescent Cells Naturally @longevitymedicalclinic

2 Sept 2026 · 1 min

Watch on YouTube

1:10

In this brief interview, the speakers discuss natural, non‑pharmaceutical strategies for reducing the body’s burden of senescent cells. The primary approach highlighted is increasing lean muscle mass: working muscle releases more than 600 peptides, enzymes, hormones, and growth factors that can actively eliminate senescent cells, potentially lowering senescent cell load by up to 40%. Conversely, adipose tissue secretes over 50 compounds that promote senescence, so lowering body fat is emphasized as a complementary tactic. The conversation also touches on fasting—particularly intermittent fasting—as another method that appears to aid senescent cell clearance, though the optimal frequency (daily, weekly, monthly) remains under investigation. Medications are acknowledged but not detailed, underscoring the focus on lifestyle‑based interventions.

Are there ways that you are helping the body clear the senescent cells out?
Yes. Yeah.
Can you talk about that?
Sure. Please. The most, quote, natural, non-pharmaceutical is simply weight loss and muscle mass. Working muscle produces over 600 peptides, enzymes, hormones, growth factors that actually kill senescent cells. Someone who maximizes working muscle mass will be able to reduce their senescent cell load by up to 40%. Also, fat produces over 50 compounds that promote senescence in our tissues, and that's one of the reasons I made a point to lower my body fat level as low as I reasonably can and kick my muscle mass up because I want to make as few senescent cells as possible. But we've also got medications.
I want to make sure we talk about fasting because fasting does a good job with that.
It does too. Sure, intermittent fasting. Yeah, and you know what your intermittent is is whether it's monthly, weekly, or daily is a a point of still research. You know, there's a lot of people still looking at this. And so I have a daily fast, if you will.
You clean up pretty well, Jer.
Well, thank you, ma'am.