Wendie Trubow, MD, MBA, IFMCPPresident at Five Journeys, Functional Medicine & Wellness Provider, Best Selling Author, Passionate Champion for Health

How the Brain Links to Today's Diseases

18 Sept 2025 · 1 min

Watch on YouTube

0:44

A short YouTube talk (speaker: Wendie Trubow, MD, MBA, IFMCP) proposing that peripheral immune reactions send information back to the brain's insula, where immune-related conditioning occurs. The speaker hypothesizes that maladaptive conditioned responses in the insula could underlie modern diseases such as autoimmune disorders, Alzheimer’s, multiple sclerosis, chronic inflammatory and neuroimmune diseases, and pain.

Chapters

And it's the first time on the planet that someone has proven that when we have a peripheral immune reaction in the body, that information that intelligence transports back to the brain into the insula so that it's ready and efficient, that the next time that thing comes along, we know exactly how to respond and we can be ahead of the curve. This shows us that conditioning can occur in the insula in terms of immunity. Then if we take that hypothesis, it means that autoimmune conditions, Alzheimer's, Ms. Chronic inflammatory diseases, neuroimmune diseases, pain, could all be stored in the insula as these condition responses that then malfunction. And that's what causes so many of the modern diseases that we see in life.