25:14

Conversation between Wendie Trubow and Dr. Deanna Minich (podcast episode) focused on melatonin, sleep, and hormone balance during perimenopause. Key points: melatonin production and antioxidant enzyme activity peak around 2–4 AM; melatonin can aid sleep and has anti-inflammatory/mitochondrial roles in perimenopause but should follow lifestyle fixes (light exposure, sleep hygiene) rather than replace them; most market melatonin is synthetic (Dr. Minich cites a 2022 review in Nutrients and states ~99% are synthetic) and may contain contaminants (a 2018 paper cited lists ~13 potential contaminants); off-the-shelf melatonin label claims can vary widely (one study cited examined 31 products with -~20% to +400% variance); Dr. Minich prefers a plant-derived whole-plant melatonin called Erbatonin and recommends CGMP/third‑party testing. The discussion also covers environmental toxin concerns (mercury, arsenic, microplastics, Fukushima/radiation), glymphatic drainage (right lateral sleep position may improve clearance), and practical lifestyle recommendations (morning bright light, reduce evening blue light, blue‑blocking glasses, schedule movement). Contact/resource: deannaminich.com.

Questions this video answers

Between 2–4 AM.

Nutrients, 2022 (she authored a review paper).

She states ~99% are synthetic.

It discussed about 13 potential contaminants that can be found in synthetic melatonin supplements.

Reported products ranging from roughly 20% less than label claim to over 400% more than label claim.

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