Everything You Need To Know About Colon Cancer Early Detection, Preventive Remedies, Cutting-Edge Medical Treatments & More With Dr. Ahvie Herskowitz.

My name is Ben Greenfield, and on this episode of the Ben Greenfield Life Podcast.

We know that people in the developed world have higher rates of cancer than in the underdeveloped world. And that may be an issue of simply reporting. We just don't know something is causing this. But the trends have already been present in the past, so the younger population has involved more.

More so fitness, nutrition, biohacking, longevity, life, optim, spirituality, and a whole lot more. Welcome to the Ben Greenfield Life Show. Are you ready to hack your life? Let's do this.

All right, folks, everything you need to know about colon cancer and cancer in general, early detection methods, preventive remedies, cutting edge medical treatments, and a whole lot more. With a three Pete guests now, Dr. Avi Herskovitz of Anutara Medicine in San Francisco. Pretty cutting edge facility that does all sorts of molecular, immunological and genomic treatments for inflammation, for cell injury, autoimmunity, heart failure, myocarditis, cancer, you name it. They have a ton of experience. They work with some of the Bay Area's top biohackers, celebrity actors, longevity enthusiasts. And Avi Herskovich is just a wealth of information, just an OG of functional medicine. So I hope you enjoyed today's show. Show notes are going to be at BenGreenfieldLife.com CancelEpisode all right, here we go. Recorded straight from Avi's clinic. And there's going to be quite a bit of extra video content that you can tune into also@BenGreenfieldLife.com CancelEpisode well, Avi, it is good to see you. It's good to be back in San Francisco. We have, we've podcasted now. Well, twice. Even though our last podcast was so big and long and hairy and audacious, we split it into a two parter. And by the way, for those of you listening in, I'll link to all of the podcasts I've done with Avi if you go to BenGreenfieldLife.com cancer episode BenGreenfieldLife.com cancer Episode and indeed, we've talked about all sorts of stuff in the past, Xavi, like constitutional assessments, which is how you first met me, eating a giant pork chop that was not conducive to my constitutional assessment. And then you fed me through the fire hose about that. And I learned a ton. We've talked about advanced blood and biomarker testing and nerve blocks and joint treatments and stem cells.

But this whole idea of cancer is something that you and I haven't taken much of a Deep dive into, besides briefly talking about these biopsies, these liquid biopsies, which I think we'll talk about a little today. But I've been very interested in cancer for a couple of reasons, and I'll have a chance to fill you in here. But one reason is that it seems to me like I've been reading a lot of articles, a lot of news reports that people are getting cancer with increasing frequency, often at younger ages. I doubt that. It's just we have better detection methods and people are just catching things earlier. But why is it that cancer seems to be on the rise across the board?

Well, I think you're. I agree that there's data sifting in now because now we can look at data from 2022.

Okay.

You know, a year behind. Of course, there's no data yet for 2023.

With a trend that predated Covid of getting certain types of cancers in younger populations. So cancer used to be, aside from leukemias and certain other cancers, was a disease of the aged with spectacular rises after the age of 75 and incidence rates. But now the group that seems to be targeted disproportionately is the 40 to 49 years.

40 to 40. So when you say young, we're not talking like 18 year olds getting cancer, but people 40 to 49, remarkably younger than this 75 plus we've seen in the past.

Right. I mean, I mean, it starts rising after 60 traditionally, but now 30 to 40 and. Or 30 to 49 is, is being hit harder. That's what the oncologists that you can talk to for anecdotal information about that they're seeing very large rises. And the more provocative thing is that these are late stage cancers, meaning that.

They have been developing for a long.

Period of time or an accelerated. Oh, an acceleration faster.

Okay.

An acceleration of that phase. So just a quick anecdote and anecdotes are just not worth their weight in gold, obviously. But they, they do heighten your awareness when you have serial studies in the same person.

Which we, we're seeing now for the first time, people with negative PET CT scans or negative MRIs. But good solid imaging for a tumor in one location, let's say a colon. Looking at the liver in, in May and looking at the. The liver six weeks later in late June.

Yeah.

Showing multiple metastases in the liver.

So with it with like a PET scan.

Yes.

Okay.

So I mean PET ct, so you're seeing it in one study, it's negative and the other study is positive. But Only six weeks has gone by and you know that it was there before, but it was too small to see.

Right.

But to go to have a six week, a mass that's six weeks that you're looking at for six weeks. Only after six weeks where you can see it at probably 2 or 3 millimeters now at 10 millimeters is spectacularly aggressive. I mean it's, this is, this is mutating, this is Excel. This is a very accelerated thing.

So even in young people.

Yes, we're seeing that. Yes. Yeah, we've seen it in all age groups of folks that coming in with later stage disease. So something is causing this. But the trends have, have already been present in the past. So the younger population has involved more. More. So breast, lung, colon, the three most silk lung is the most common cancer in the United States. Then, then colon is second. But happening in younger people.

And just to address the elephant in the room, this is not because people at younger and younger ages are out getting pet scans and MRIs because you know, Tony Robbins is championing the benefits of a full body mri and all the biohacking and anti aging enthusiasts got to go out and get their advanced, you know, CT angiographies and everything. It's not a matter of us testing younger people. You think there's actually something going on causing cancer at a younger age?

Right? Well, it's very unlikely that that's the reason. So, and, and during the pandemic, the first year, the pandemics in 2020, 2021, there was a decrease in cancer incidence and that was because we weren't identifying people in, in a timely.

People just like weren't going to the.

Hospital, they weren't going to the hospital, they weren't getting screening tests. So we lost a lot of the folks with earlier cancers at that point. And then in 2022 it's now back to pre pandemic levels. So, so that's one, one message. At the same time, there are entities now that'll do whole body MRIs specifically to find that lesion that's early somewhere in your body, some 200 plus cancers that they can identify. And we've seen a case like that. But one case out of hundreds of cases you need to follow in that particular fashion is very inefficient to take these screening tests willy nilly. And we'll talk about that. Even when you're, you're concerned about cancer and you look at these tests, we'll go over the different findings with the test, but it's unlikely. Okay, so The. The elephant in the. In the room is also, what is the impact of COVID and what is the impact of vaccination on this trend that already was accelerated?

Yeah, well, how do you even know? Because. Because you have the COVID pandemic. But it sounds like the trend was already accelerated. We have vaccinations which have been around for a long time. We have some new ones, but then there is, of course, stress and emotional processing, which I know has a very large correlation. I just got done with a book called Anti cancer Living, which is all about how human connectivity or the absence of it and loneliness is one of the biggest contributing factors to onset of cancer or even poor cancer survival. We've got. You go back and read books that kind of get an eyebrow raised at them. Like the electric rainbow that talks about increased incidences of chronic diseases with response to excess exposure to WI fi and electromagnetic radiation and radio frequencies and cell towers. We have ultra processed food and toxins in the. In the food supply. I just interviewed a guy last week who talked about pesticide companies creating small short chain peptides that replicate cone snail venom, cobra venom, and scorpion venom, and that these venoms may cause a steep rise in the instance of cancer. Is it like a cluster of a bunch of things, you think, or.

Is that a crazy idea?

My hypothesis, when I first opened up this clinic, Anatara Medicine in San Francisco about a dozen years or so ago, was that our area under the curve of these individual risks is now taking a transformational shift and putting us into a much higher risks than we had before. It's an area under the curve. So it's multiple factors, always, as, you know, all the different factors you just cited, and many, many more.

With both specific cancers as well as. As others. What we do know, let's just take it from the top. Okay. Okay. What do we know? We know that people in the developed world have higher rates of cancer than in the underdeveloped world. And that may be an issue of simply reporting. We. We just don't know.

Yeah.

Now in the countries that do report well.

And, and there are Latin American countries that do that and African countries that do that, it tends to be still higher.

In the developed world, undeveloped countries that report well still have lower incidences of cancer than developed countries.

They have specific. They have regional cancers, you know, but, but overall, as a general trend, that's one thing about the way we live versus the way they live, that it has to be taken into account. So of course, there's many different factors, and we'll Talk about each of them. And then in the United States, and then when you say, well, what's going on in the United States? Well, the United States ranks In the top 10, 15% of all nations with cancer rates. But not as much as Germany and not as much as Czechoslovakia is like not the number one. And number two is Australia for some reason that you know. So are people in Czechoslovakia drinking more alcohol? Are the Australians drinking more alcohol? Are they exposed to some specific regional toxins that we're not aware of? They're not less, they're not more sedentary than we are. Certain things are clear. They're eating the same food as we are, maybe even a better food supply than we are. So there are multiple factors going on. But why has lung cancer, for example, still the number one cancer worldwide? Even in places that don't have high smoking rates anymore? So we've reduced smoking rates and actually alcohol rates in France and Italy are going down.

But although air pollution is still a pretty heavy issue that, so that's and a growing issue.

So you're left with the area under the curve that something else is supplanted what was exposed by smoking. And now you remove the smoking from the equation and you still have, you still have it because the rates of air pollution over and the rates of inflammatory states in the lung that we're constantly inflammatory interacting with the pollution.

And when you say smoking has decreased, at the same time we've seen a concomitant increase in vaping of nicotine and cannabis. And from what I understand that at this point is dwarfing the rate of decrease of cigarette smoking.

That's correct.

People sucking down polyethylene glycol all day.

That's true. And that's a disaster in the making because again, the exposure to environmental toxins and food toxins and oncogenes and viruses and so on. So when you say I want to see what the area under the curve is, well, I have to know that on an individual basis.

We're not talking about epidemiology now, we're talking about natural history, natural history of cancers we know are affected by the inflammasome, this inflammatory cascade that's generally much more pro inflammatory today than it was 20, 30, 40, 50 years ago. We understand that to be a fact.

The inflammasome.

So this is the pro inflammatory signaling. So when I first became immunologically trained, we had, you know, 3, 4 cytokines that we knew about. TNF Alpha, Illinois 1, Illinois 2.

Those are inflammatory molecules.

These are cytokines that talk, communicate. So generally speaking, you'd say certain ones are modulatory, like interferons or modulatory, and certain ones are pro inflammatory. The one that's probably the most commonly known are TNF alpha and the IL1 and IL2 receptors. But you need them to exist. I mean, they're not bad, they're just constantly activated. So when you study this today versus and now we have, we know that the Cascade is about 300 of these communicating molecules, these inflammatory molecules, these signaling molecules that some tend towards inflammation, most of them tend towards inflammation, inflammation, repair, overlap. So many of them are useful in repair, Many tend you to autoimmunity, many tend you to allergic phenomenon. But they're all in a cascade. No supercomputer today can figure out any. If you measure all 300 in a person, no one's going to be able to figure out the puzzle at this particular point in time. But we know that the overall inflammatory state is now pretty secured in the population. You know that if you go out drinking and eating junk food the next morning, you're inflammatory, period.

Yeah.

You can measure it with the basic, basic, basic stuff like C reactive protein.

Yeah.

Because it's an acute phase reactant, it'll go up.

You know, qualitative measurements like how long you lay in bed watching Netflix when you wake up because everything just feels too hard. Right.

And it has total body effects. We know that if you, if you're sensitive to it. The reason you feel crummy is because a lot, a lot of that is because of these inflammatory signaling molecules give you a touch of the flu. Even though you don't have fever, you don't have a virus, just this. It feels the same way. Your fatigue feels the same way. It's just not as extreme as it is when you're.

And so what you're saying is that you have. Because I know you do. And we talked about this in our last podcast, a much more comprehensive series of inflammatory marker measurements than you might get on the average blood test. You're saying that an increase in those inflammatory markers is something that has risen in correlation to this rising cancer. Yes.

And that could be due to some of the other things we talked about. Toxins, electromagnetic soup, ultra processed foods and ingredients, animal venoms, poor emotions and lifestyle and stress, etc, like any of those things could cause rise.

Right. But the reason I bring it up today, because we're talking about cancer, is I think that that aspect of things is not discussed in depth as it should be, because it's you know everyone. Oh, I know that I'm eating ultra processed foods and the chemicals, they're bad for me. I understand that but. But it's okay that I might. My doctor said my C. Active protein is 5 or 4. The upper limit is 3. But we want everybody to have it less than 1, less than 0.1. I mean it should be 0.

Yeah, period. And that unless you just got done with a workout.

Yes, but, but, but by the next morning, right. You should be back to baseline. So when you're running around with the inflammasome activated in a pro inflammatory way. That's what inflammasome means. It's this pro inflammatory inflammatory cascade is good and bad. You need, you need both. You need, you need it to survive. You can't, you can't exist only on antioxidants.

Yeah, but why, why is. Because, because like obviously if you exercise, you know me like I'm. That's my jam. Like my business is exercise science and fitness. To a great extent you create inflammation. You know, arguably even if you do a hefty sauna session or something like that, you could create hyperthermia based inflammation.

But you don't see people who exercise frequently or lift weights, it seems at least getting cancer at as high a rate as someone who develops inflammation from say a toxic lifestyle. Ultra processed food. So there must be a certain flavor of inflammation or a certain environment in which the inflammation takes place that would cause the rise in cancer.

Yeah, that's correct. So inflammation and repair go hand in hand. I mean there's a tremendous overlap. So when you microscopically injure a muscle by overuse, it requires the same cytokines that also would produce in a chronic state an inflammatory state that is not reparative. Yeah, so it goes overboard, it's not modulated back.

Right.

And why is, why is that? Well, well some of the major modulatory pathways are completely off now. What are, what are they? Vitamin D pathway is one of the major immunomodulatory pathways. I mean it's a, it's a hormone, it's not a vitamin. So that hormone is responsible to modulate your immune system back to the center. It does so not just by acting as an anti inflammatory. It is not, it's a, it. It goes through sets of hundreds of pathways including anti inflammatory pathways. But it also modulates with the renin angiotensin system that has, that is the target of COVID That's why I bring it up. It's a target of setting the system out of its modulatory pathway. So, for example, you could argue that the cancer rates have really been pretty flat despite, you know, treatments, and despite everything, the death rates are pretty flat overall for the last 30 years. Well, we. We have better treatments, better surgeries, better chemotherapies, more targeted immunotherapies. We have those, but it hasn't really made a huge dent. I mean, certain. Certain ones on a total. Totally. That the total number hasn't changed. And the total number is anticipated in the modeling today is anticipated based on these other factors that modelers put in. Like what's the effect of being more inflammatory than we used to be? What's the effect of being more stressed than we used to be? What's the effect of a more miserable biome that we currently treat ourselves with? What is that effect?

It's going to rise by 60 to 70% by 2040. So whatever the numbers are, they're going to go up.

According to logic and according to the model.

Yeah. So it sounds to me like we might not know the exact reason, Even though there's a cluster of clues as to why it's increasing. But I think that what I'm interested in is how people like me in our young virile ages can actually know. This morning I got up at the holiday inn last night, the front desk called up and said my pee cups were here. And I went downstairs and I gave my first morning void. And I brought that in, which I think has something to do along with this needle in my arm, with the type of ways that you can detect whether or not a young person or an old person would be getting cancer even before you might see a pet scan or an mri. This is interesting to me because I haven't even told you this. Six weeks ago, my dad showed up at my house with gut pain. And he has a history, you know, he's ashkenazi Jewish, which I think has a little history of gut issues as well. I even have a princess gut myself. And so I said, oh, our daddy, you know, everything you're talking about, it sounds like diverticulitis, some inflammation. And, you know, I cleaned up his diet for that day, and I brought him down to my friend who's a naturopath. We gave him about vitamin C, IV and some ozone. And as I was driving him home, his pain was just getting worse and worse. And I said, dad, something's not right here. I'm going to take you into the er. So I pulled a ue on the road, took me to the ER Long story short is via a series of scans, you know, CT scan, chest X ray, et cetera, the nurse came into the room and said, well, Mr. Greenfield, you know, we thought this was diverticulitis or some type of inflammatory pocket in your colon, but it's instead like a pretty massive growth. As a matter of fact, when we met with the physician for a follow up a few days later, after more scanning, they said that it was likely that the size of the growth, this tumor that was blocking nearly his entire digestive tract, had been growing for nearly 10 years. And I don't know if that is the case, but regardless, went in for emergency surgery because it had progressed to a pretty concerning point. Almost died in the hospital three times with sepsis and surgical complications. And it was very emotional time. Just six days ago, he was discharged from the hospital and he's now at home. But I've been calling up my brothers and saying, well, look, three cousins on our mom's side have died of colon cancer. My grandfather died of colon cancer. Now we know my dad, who was adopted, we didn't know his genetic history, obviously has some issues, and there's likely issues on his side. We gotta get colonoscopies, guys, and we gotta start to do some detection and also begin to educate ourselves on the treatment. I've been on this, on this journey to learn more and more about why it happens and how we can detect it. And so that, that kind of leads into my next question for you. You know, you got me, you got my, my two brothers, and we're sitting here quaking in our boots. Maybe we have something that even a PET scan or an MRI wouldn't be able to pick up. What do you do? What's your screening method?

Well, let's just again take it from the top.

There some factors that we know about. So you've heard the genetics mediates some percentage of risk, whether it's cardiovascular or Alzheimer's risks, so on. So somewhere in the, in the low range, 5, 10%, something like that. But for colon cancer, there is a specific genomic alteration called lynch syndrome. These are the, the genes that deal with the. Repairing your DNA at night. Mismatch, interesting. Mismatched genes. So these are the genes that, that repair at night. So when they're, when the copy is not exactly the same as the original, they. They repair that. So there's a group of maybe about 10 genes. So the lynch syndrome people have an increased risk. And, and for colon cancer, specifically all the gut cancers, but mainly colon cancer.

And that's where you have to be very aggressive in terms of colonoscopies much more often. So. And I'll explain why colonoscopy is the. Is the better way to go. Okay. For. For them, but also probably for the entire population, although we would all like it to be easier than that. And I'll review all that too. But so, so that's one thing. So let's just assume that only occupies a small portion of people. It's probably not. Not your dad, because your dad is getting colon cancer at an age that is standard.

Yeah. 70.

You know, a standard. A standard colon cancer.

The three cousins on my mom's side who are more like 40.

So that's the, that's the risk. The risk is there on that side of the family. But.

So it's. They've been there for a long time. It's enough to obstruct. And that's a not an uncommon scenario because unless you go to the doctor and, or, or buy a Guayac stool test and say that I'm leaking a tiny bit of blood microscopically.

A guai X?

No, it's called Gu. A IAC Guayac. It's just a stool. It's a stool test for blood.

Oh, okay.

And microscopic amount of blood. This is not when you, you're seeing blood.

Right.

In the toilet. This is when you can see it.

Right.

Typically, someone like your dad may, may actually have an anemia from that microscopic loss of blood over the years, which he didn't notice because ultimately it obstructed him. Right.

Yeah.

And, and then by that point, he may be unfortunate enough to have metastatic disease and local disease or local lymph node involvement or metastatic disease. But the, the point is, what do you do when you're 40 and 50 to figure this stuff out in advance?

Especially if you don't just want to get a series of colonoscopies every year.

No, no, I understand.

For example.

Yeah, of course. But, but, but Right. But right now, even, even the trend to younger, younger age groups getting colon cancer just as on a national level, to understand that there used to be, when the first came out, that colonoscopies were only paid for by insurance. If you were, even if you were. It was 8, it was 50, and now it's lowered to 45. They're not going to go lower than that because it's going to be prohibitive a. Expensive for them. But there's not enough tubes to go.

Around to shove up people's butts.

Right. I mean, so, so ultimately Even if you're asymptomatic, 45, you can get your, your first one and then not another one for 10 years.

Okay.

Unless you find a polyp. You, you could say, listen, I'm willing to take a colo guard test, you know, which is a cologuard test. Cologuard, C O L O G U A R D. Which is a test. Also a test that's based on DNA. Mutated DNAs that are found in the colon secreted by colon cancer.

I've seen this once. Is it like a blood test that you send in that has a certain percentage rate of being able to pick up colon cancer specifically?

So that has a pretty good positive predictive value. It means if it's positive, it's good. That means you already have it. Right. Okay, so it's not preventative at all. It just is. Maybe, maybe you'll catch it earlier.

And this is something anybody's doctor could order for them?

That's correct.

Okay.

I, I think you can order it. You may be able to order it soon on your own. It's not going to be covered by.

Home test kit, type of things, something like that.

Yes, but the. But you have to be. You have to fulfill very strict criteria. They won't run it if you're below 45. 5. They just don't want it. You can't.

Even if you have high genetic risk.

No, no. They want and they don't want. They don't want you if you have high genetic risk. For some reason I don't quite understand all the different odd things. So you have to be asymptomatic and you have to be above 45 and not have a family history. And so why they stay away from there, I don't know. Perhaps it's something to do with. I, I can't afford to have a true. A false negative test in the population.

Okay.

And that population really needs to go to colonoscopy. The only, the major advantage of colonoscopy, even though you have to be prepared and prepped and then put under anesthesia, of course, is the fact that you're going to find in a higher number of people, not cancer, but you're going to find the precancerous lesions that the, that the blood tests can never.

Those called the polyps. Okay, so how big are those, by the way?

They can.

Oh, when polyps. I think about a bunch of mushroom spores when I'm walking through the forest or something like that, but.

Right, so you'll pick it up on a Colonoscopy if it's about a half a half a centimeter.

A half a centimeter. Okay. All right.

It doesn't have to look like a bulbous mushroom like you see in a cartoon. Yeah, but, but in any case, at that point it's, it's precancerous, it's, it's, it's an adenoma. It's not, it doesn't have dysplasia and it doesn't have an abnormal cell type in it. But it also sometimes can actually have a carcinoma in situ right there. And you just, you clip it off and you're done. But then, then you owe yourself another colonoscopy. In five years.

In five years. And so that's what I'm wondering, obviously with what you were talking about earlier with this rate of cancer growth, I mean, you cited a figure of six weeks. You could do a colonoscopy, get a polyps removed or not. If you don't find one, wait five years and by five years have a pretty massive growth. It sounds like the cologuard test could be one option as a blood based screening. Is that the best one out there?

Probably. For colon, yes. There's the gallery G A L L E R I test, gallery test that. There's also a blood based DNA test that can measure about 120 different cancers at one time. Again, very strong positive predictive value. That means that if you have a positive result 99 times out of a hundred, you, you have cancer.

Is that the one you were telling me about that you send off to Europe?

No, that's different. So we'll get to that.

Okay.

But it's poor for early stage. So stage one, they only, they only can identify 40%.

Okay.

Stage two, 60, stage three, 80 and 95 of stage four cancer. So your father would have a positive gallery test, but he obviously knows he has cancer.

Yeah.

And if he knew about it six weeks earlier, it wouldn't have made much of a difference.

Probably not.

But if he, if he was wanting to predict five years ago when he had perhaps had a very early stage disease, it wouldn't be a great test to use. So we send the test off there. There are multiple German based tests.

And by the way, is this a blood test that you send?

Blood tests? Yeah.

Okay.

This you need a doctor for. There's a few German entities. The one we send moved laboratories over to Greece. We call it the Greek test, the RGCC test. It actually means something. It's the name of their lab.

RGCC is the name of the lab in Greece that you send these tests, but using German.

The German technology that he brought over. So this is a brilliant German immunology oncologist who. Who put forward the methodology to. To. To look at multiple cancer stem cell receptors on circulating blood.

Okay.

So and. And finding it in small numbers.

Is this what you would call a liquid cancer biopsy?

Yeah, so this is the liquid biopsy. So. So there's a liquid biopsy revolution happening in the United States, which we'll talk about, but this one is the. The technologies in Europe currently that are approved there, but not here at this point.

Will. Will show you results when you don't. When you have a circulating marker that's abnormal, but you can't find the tumor in that location. It's not visible yet.

Yeah, yeah.

So. So. So you're catching it truly in an early.

Even before what you could potentially find in a colonoscopy.

Oh, yeah.

Wow.

Yeah. Okay, so. So once that polyp turns cancerous and it's more than a millimeter or 2 millimeters in size, it will leak into the bloodstream, and then in the bloodstream, it has a life of its own because the cancer stem cells are immortal and they're immortalized so that they exist there and they grow a certain amount. But even in low numbers, they can be picked up. And then you have to track it down sometimes. Each of the different tests, the one that we use can pick up prostate specific, breast specific, squamous cell specific cancer.

Oh, so you don't send off the test and say, hey, we want to test this for colon cancer. We'll just test all of them.

So there's one panel. You get hematologic because, you know, lymphomas and Leuke. Lymphomas are up and leukemias are up and myeloma is up. And then they run it all. They run it on everyone, but they have a different panel for the epithelial. Epithelial, like cancer for the solid tumors.

Okay. And if someone's listening in, how do they even find a doctor who would run a test like that? Do you just do it like a Google search for this RGCC test?

Well, you go to their particular website, I mean, and they'll.

The RGCC website?

Yeah, because they'll. I mean, obviously we do them a lot, and we do them a lot for other doctors, because in. In the Bay Area.

But someone still has to come into the clinic. The clinic.

They have to, because it's a. It's a. It's a real blood draw. So you have to take 30, 50, 40, 50 ccs.

Is that what they did on me this morning, this, this blood draw?

No, that was, that was filling in everything that I'm going to talk about from now on with regards to, to really having a, a cancer prevention stack of data.

Okay.

Okay, but we've already sent your test over there as it was negative. Right. Didn't we send the RGCC test?

I don't know. I lose track of all the things you do to me. Yeah, okay.

I think we did.

Okay, so what are these other tests.

That you do then?

Like the ones that you, that you drew from my blood today?

Well.

I, I figured that if I let the, the clinic grow organically when we first opened that we would learn more than if we restricted it. Coming from immunology and cardiology background. I mean this never, never came close to becoming a cardiovascular risk reduction type of a place.

Because it was open to everyone and the folks and the inflammatory state sort of was king here for the first 10 years.

So what's that mean, open to everyone?

I mean, we didn't select patients, patients who, who came through the door. Came through the door. And then we noticed that we had to find our solution. Best care solutions for cancer care patients. And they were in two different groups. One that was doing traditional chemo and one that had an affinity towards just doing it in an alternative integrative way.

So apricot kernels and high heat saunas and all that stuff.

Right, right. So, but, but, but there was, but there's an over. So that, so we had this, this extraordinary data set from cancer care patients and understood what was associated with that. And I'll, and I'll talk to that in a minute. But then we also were interested, because of my own age, I was interested in long, tremendously interested in longevity and its interaction with the immune system. So when you look at cancer prevention, it's wise to look at what the drivers of longevity are because it's, it's the same thing. It's sort of, it's an accelerated form area under the curve pushing you in, into mutational forms. But when you look at it, we sort of also forget some of the most basic stuff. So for example, the single most important piece of information that we'll get from your urine, the early morning urine that you and your wife burn in, was your urine ph.

Your urine ph. You can get that from just like a pee test strip, right?

No, you can get that for $4 from any Walgreens but that's a single one of the most important tests you can use every day for cancer screening.

Really?

Yeah. I'll tell you why it's of kind so.

Because you know from your own studies that having a more alkaline urine means that at night you, you, you repaired more DNA. You repaired, you produce more pro. More. More reparative proteins. You know you'll recover faster. Right. If you're acidic. So a lot. Most of the people walking the street have urine pH of five or five and a half. They're quite acidic.

Which is very acidic. Yeah.

So that is, that's a pro cancer environment. Period. End of sentence. The tumor micro environment is acidic. It's also hypoxic.

But that's the information based off Warburg's hypothesis.

That's right.

Are growing in a hypoxic anaerobic lactic acid accumulated environment.

That's correct. So. So.

And most doctors don't think about that. That's, that's, that's the most important thing to change and one of the most important. And that's the one that's also been associated with longer life. If you look at this few things that have been documented in the literature that are associated with longevity. Early morning ph between 6 and a half and 7 and a half rather than lower or higher. Mainly lower is associated with longer life.

Well so we all just need to get one of those Kangen alkaline water generators. Right.

Maybe that would work. I, I don't know if it would work because the question is what gives you the effect? And the effect is mainly from food and, and, and from shifting your metabolic system into a better state.

Poor kidney function, mineral depletion. There's a lot.

There's a lot there.

So. Yeah.

And some of us get it back by just simply taking it a different approach to nutrition.

But then what, what, what are the drivers what drives longevity that we know about been proven is vitamin D, hemoglobin A1C for your blood sugar metabolism. We know that from Warburg's days that, that tumor cells love glycogen and glucose. So having that under control.

So pH, hemoglobin A1C, vitamin D, glucose. These are all things that you would test. These are very basic tests.

They're very, very basic. Yeah. But looking at them as a stack, you have to include whatever you're measuring. Most of us have normal renal function and liver function. Okay. But you have to add C reactive protein has been shown to you live longer and that's pretty much about it. That's Been.

That's not documented, expensive or fancy series of tests, man, that's not sexy.

No, but I, I think it's, it's lack. It's lacking. Okay. It's lacking because we, we've identified a much deeper data set that is much. That is.

Oh, so you go beyond just what you just told me.

Yeah, because. Okay, the only, the only immunological marker there is are you inflammatory or not? And it's one of the more basic ones. I mean, it's just basic. Everyone does a C reactive protein that has their normal, I don't know, cardiac risk factors. Done.

So you need to go more. So, for example, what is the area under the curve of all the toxicity end up doing what? What is it doing in everybody? Well, it's affecting everyone's biome and that's a. Well, and we have to get into that. But it also affects our innate natural immune system. The, the summation of all the, all the pollution, all the chemicals and so on affects it. So what that means is our surveillance system looking for foreignness, looking for foreign proteins, looking for mutations which are foreign, is suppressed. Okay. Then you add the absolute epidemic of toxic mold, which is also a suppressant, and then the epidemic of having most people today having a very large viral load over when they were kids. I've also heard in addition to mold.

And viruses, parasites can also be a contributory factor.

Except one interesting thing. Having worked in global health for a long time and traveled all over the world, that again, when you look at the association between countries with heavy parasite loads, they have a lot of stuff, but they don't have autoimmunity and they don't have cancer.

They also eat a lot of hot peppers.

Yeah. And they eat, they eat what they eat.

Yeah, those Thai ghost peppers. No cancer can survive that.

That's true. So, so when you, when you add something that measures some measure. So it's not the fanciest 100 cytokine panel that, you know, we can organize here, but you measure something called natural killer cells. So These are the CD8NK natural killer cells which are labeled CD57. These are what we call here in the office. Oh, just do a CD 57 count. And everyone knows what we mean. So that has a huge range of 60 to 360. The range is really high. You know, it's very, very broad. But if you're, if you're less than a hundred, if that's the number that you have, then you're less than that, then you have some work to do. And, and that's to me, the, one of the, one of the most fundamental reasons I like thymus and alpha 1 as a peptide because it can move that number up. Now you have a very high number.

Can move the killer cell.

The killer cell. So. Yeah, so. So one thing I find that's a cute story is someone comes in and is proud to tell me that, you know, everyone is sick in my family. I never get sick. I'm just the one who's so strong and never gets sick. And I tell, I sit them down and saying that's not good news.

It's not good news.

It's not good news. No. It means your innate system is asleep. I mean, get sick once in a while.

But couldn't it also mean you have like, good vitamin D status and toxins.

But then you don't get sick very often? But the last time I got sick was 12 years ago. Doesn't make sense.

Yeah.

To me. Because you're in, you're in, you're in everyone else's environment. So you're right. Most people are getting sick too often.

Yeah.

And they're gonna say you're making me.

Nervous because I rarely get sick.

Well. But yeah, I'm saying. So. Yeah. But your number is, is really high.

My number.

You have CD57, seven natural killer cells is really high. And we'll see what, what your wife says.

Yeah.

Today. So. And that's to me. When we, when we apply AI to our data set, we'll find. I think that there's a strong likelihood that we'll find that CD 57 counts will, will be associated with longevity.

Okay. Okay. And you, you also said thymus and alpha 1 peptide is A, that can increase that.

Yeah. So this is the thymus. The thymus communicator. Thymus is governing our immune systems until we're adolescents, 12, 13, 14 years of age, and then disappears. So it's a peptide. And we, we always have our. We're right here next to the major street with, with all the San Francisco baby. We're in a big city. Yeah. So that can move, that can move the number up.

The way you, you, you train your thymus gland is when your mom breastfeeds you with colostrum. Oh, so that's, that's, that's the. But that's real. Real.

That's why my levels are so high, because I do colostrum almost every day.

But you know, I, I don't believe that that's the case. But that's because the colostrum that we Eat is we take in as a supplement. May or may not. I don't know. We have to see. But, but that's where it comes from. So thymosin can, can act on it. But you, you say, well I want, I want to know what my number is. And about 9. 9.

To 95% of the. Of the cancer patients have very low CD 57 counts, have very low natural killer cell counts. And the ones that get cured all have them raised up okay. Over time. So they clean up, clean up. And then.

So this one reason people go and do like NK killer cell treatments in Mexico and things like that, sort of.

It seems that that's logical. I don't know. I don't know that anyone's proven that that makes a big difference, but that makes sense. Yeah, but that's where what suppresses it? Mold, oral infections, the deep oral infections from root canals, the deep sinus infections that are occult.

And.

Heavy metals. All of it, you know, and then you have the, the biome consistently being a source of, of inflammation. So.

Yeah. So you mean like gastric inflammation?

Well, gas, yeah. The whole GI system is. We have explosion of placebo, we have an explosion of dysbiosis. So dysbiosis, that's untreated. So you say it's okay. I only pass gas once or twice a day and I, I have my bowel movements every twice every two days. That's completely unacceptable.

Every two days a long time.

Completely unacceptable.

I can't hit even once at all in the morning without, without having a giant dump toilet filling dump.

The masters in the, in the, in the developing world that take care of themselves 100 naturally and do it. You know, they're pooping every time they. After every ever after every meal. But I think twice a day is quite normal. But you know, again, sometimes we're even suppressing our desire to go to the bathroom because we're too busy.

Yeah, I'm a 2 it air 7am and 4pm like clockwork, baby.

Well, that's cool. Well, that's. Well, that means your elimination pathway, your major, the major one that you're using for toxins. I mean urinary function is normal and almost. And so much so so much of the population. But pooping is not, you know, and so you have to regulate that. And so then you have to say, well, what's my, what's my detox area under the curve? What do I need to get out of my system? Well, you have to measure it. I can't, I can't guess what it is. And looking at blood, blood tests for heavy metals and all the toxins is not appropriate because these are in the deep tissue. So you have to provoke them out. So blood test that shows you low in lead and mercury is worthless. Yeah, just now if it's positive, it's already elevated. You don't need to, you just need to know the provoked level to see where my baseline is, how long. Then you could predict how long you're going to need to chelate it out. Yeah, but in the mold takes and, and to change the subject back to mold, again, it takes time and mold is not easy. It doesn't happen overnight. You gotta, you gotta take the binders for which you were started on probably for 12 to 18 months to get it out. Yeah.

You know, there's a couple of good books, one by Nasha Winters and one by Lee Aaron Connolly, both books about cancer screening and much of what you're saying. I've seen some of these same tests in those books. I'll certainly in the show notes@bengreenfieldlife.com cancerepisode so I'll link to those titles if you guys want to take a look at a comprehensive review of some of these labs in case you weren't writing down notes like I am right now. But I guess it's important beyond testing, I think, to talk a little bit about what you particularly in your practice would do. Let's say you find a young person who you've found tests positive with one of these cancer screenings or at least shows a lot of the signs or even shows a significant growth on a PET scan or an MRI or a colonoscopy. I mentioned slightly ingest, but slightly not apricot kernels and ivermectin and monoclonal antibodies and drinking your own pee and going off to Mexico for the killer T cells or off to Paracelsus in Germany for the hyperthermia. And, you know, and so there's just so many remedies out there that it seems like you can't swing a cat by the tail without hitting one. And then with my dad, with what's going on, everybody's like coming out of the woodwork. Your dad needs to do this, your dad needs to do that. I respect you and your opinions on these matters. You're very well connected in the medical community. So what's your general approach as far as the things that really seem to move the dial for cancer treatments?

So, as you know, on, on the big picture side, the earlier, better the earlier, the earlier, the Better. So early detection, even with, with nothing about what we're talking about, when you get, when you get into the system earlier, you know, at stage one versus stage three and four, it's a, it's a big, it's a big survival difference. So, so that's. So that teaches you. So when you get super early with these liquid biopsies.

Then we have never had a person that's been treated here in the, in the 12 years that has had a liquid biopsy that showed circulating tumor cells that has advanced really.

Because of the treatments that you're.

Because of the, of the laboratory screens and then fixing what you're. If you're depleted in something fundamental, then you have to replace it. You have to understand that for some reason you need more magnesium than the person next door. Sometimes, you know, you have something going on with the vitamin D receptor. You need more vitamin D and you need to reduce your carb load.

That makes sense. But so many people talk. But you got to like cut and burn and get it out of the system, the cancer.

Well, I'm saying. But here you don't. You can't even find the cancer because it's very, very, very early. So you have that five years in order to. Yeah, yeah. So. So no one's ever progressed. And the great majority of them go to back to zero. Wow.

And.

One lesson we learned about that was we used to ask patients to do the test every month. It's an expensive test.

Do which test?

Do this RGCC test every month, the rgcc. So they would have. They start off with, let's say the number was three, and then to two, then to one, then to 000 003. What happened? Oh, my husband got ill. I went off my routine. Tremendous stress.

And you said they went off their routine. They specifically were going off of the replenishment routine for whatever vitamin D or magnesium or anything else you have.

And then. And then you go back on the routine back to zero. So you have to be aware that, you know, cure. Cure is, is. Is it may take another five years if it was left on untreated in some way by you unadjusted. But, but it could come back. So, so, but that's one group and that's the best possible group because it doesn't change. Change your life forever other than making you healthier than you've ever been. Now if you're stage one.

That'S where we start saying all of this shouldn't be done, or stage one or two, all this shouldn't be done orally. I mean, you have to replace what you're depleted in. You have to detox. You have to get rid of your root. You know, the infections in the root canals, you have to get them mold out over time.

Yeah.

It's not an emergency.

All things you'd probably want to do even if you didn't have cancer.

Well, that's the point. If you want to live longer, it's the same gig. Yeah, but if you want to end up to be stronger than you've ever been and be alive and know that you're actually cured, you have to go to a, To. To intravenous chelation. You have to go to IVs to. To replace, replenish, and get there faster because you don't have an endless amount of time to wait.

Yeah. If you found cancer in its later stages, you can use those more aggressive approaches. Approaches.

And even with stage.

Three or four. But obviously with stage four, you have a very limited time because. And it seems to be that the cancers are getting a bit more on the aggressive side, so you have less time. And then we have our approach which takes in the. The. The German biological medicine approach that subsumes it into our.

Which I'm kind of familiar with. I don't know if I told you this. I took a whole group of people, like three years ago, more than that, on a medical tourism trip to the Swiss clinic in Switzerland, of all places. And it was up in the Alps. They did a lot of these German European biological treatments. I spent four hours in a hyperthermia chamber just to see what it was like. Lots of IVs, lots of chelation, lots of ozone. And so these are the type of protocols that you'd have to go to Europe to do.

No, no, you can do them here. Really. What we don't have. What we don't. In this particular clinic, in our clinic, we don't. We use a surrogate of hyperthermia. When you look at the mechanism of action of hypothermia, it. It induces heat shock proteins and that runs a cascade that ultimately ends up to have more oxygen in cells. And tumor cells don't have antioxidants. So we have. We use the. The laser frequencies to get the same. To get the same.

Oh, she'll generate heat shock proteins. With lasers.

With lasers, yeah. So we use that.

Convenient.

But otherwise. And we use obviously all the same IVs. All of our. Most of our IVs are. Are.

You don't have to go to Europe.

No, you don't you don't no more. And, and the, the trouble with going to Europe is very simple. And that is you can't stay there forever. You know, you want to be able to do it.

Ask my wife. She'd probably like to closer to home.

But at the same time, your wife's going to go there just to do their version of rejuvenation.

Yeah.

So that's fine. But you can do chelation here. Of course. My organization that I'm President of called ACAM, we brought chelation to the United States 50 years ago.

With chelation basically being a detoxification.

Yes.

Protocol. Any particular strategy for that? For the chelation?

Well, when you're chelating orally, you, you can only do it for. Let's say we start off with three days on chelate on chelating agents and then 11 days off and you're, you're.

Consuming a chelating agent orally. That's binding toxins.

I'm also binding your minerals via urine.

And stool and sweat.

That's right. But they're also binding your nutrients. You can run all the time. Yeah. But intravenously you do it once a week.

Okay.

In Germany, in a cancer protocol, even here, you'd probably end up doing it twice a week.

Yeah.

And, and, but we have a more immunological based system here trying to get your own immune system to work on your behalf 247 than the Germans do. So we're more focused because of my background in that area.

Yeah. Okay.

So we're more advanced. Advanced in that particular area, I guess.

Yeah.

And, and hyperthermia is, is also uses the same type of mechanisms. And there are the world's best hyperthermia units, probably in Germany. But again, you have to stay there. And.

Yeah.

This is not a single treatment you can, you can go through 20.

Hyperthermia for people who don't know, it's way more than just a sauna. Like is this pod and just your head start sticking out and you got a rectal probe in to gauge your temperature and you're getting extremely hot.

Yeah.

Inducing a full body fever, basically. Right. Like 105, 106, something like that.

And then some of the centers take you so high, which is a reasonable thing if you can tolerate it under general anesthesia.

Yeah.

So. But I do want to mention something. There's another marker that I think is going to end up going on to the longevity list. Really, which is a very bad marker to have when you have cancer, and that is ferritin.

Really?

So ferritin is A iron store marker.

Yeah, iron storage protein.

But you know about oxidation and you know about lipid peroxides and you've heard that term before. But basically our oxidative stress state that we're in.

Produces rust from the iron. Now iron is everywhere. Hemoglobin cell repair mechanisms, all the phosphorylated enzymes that are working on all the systems that we know are anti cancer also contain iron as part of their molecules. But when you're oxidizing produces a food for, for tumors. So. So the ferritin starts going up.

Is that why red meat can be a predisposing factor for cancer?

I, I think that red meat is probably has been shown in literature to be predisposing for cancer at a relative risk of let's say 1.2 to 1, 1.3 to 1. Smoking is higher, alcohol ingestion is higher.

Yeah.

Red meat countries. Yes, but they don't.

Do they break that out between processed craft red meat as a McDonald's versus like a. I've wondered that before because I think I still limit my red meat consumption. I probably have it one or two times a week and I'm careful with pork chops now based on your advice. But I've been doing a lot more fish and poultry to a limited extent just since my father's cancer battle.

But nowhere in the literature does it suggest that eating less than a pound of meat a week is ever been increased, you know, in terms of cancer risk.

Okay, less than a pound.

I mean that's eating, that's eating, you know, meat from our.

Wholesalers. You know, that's eating the meat you get at Safeway and. Right, and Costco.

Right. So your average processed grain fed high omega 6. That's right, yeah.

So that, that's a talk that has its own toxicity. So. So.

I don't preclude my patients to eat meat at the same time. The ferritin number, unless it's normal. You're not going to be cured. You're not going to get cured. Something is still quite off. You need more antioxidants, you need a better metabolic system overall.

Are you familiar at all with the root cause protocol by More Than Robbins, which basically is a copper and mineral based protocol and part of it is designed to limit the amount of oxidation that takes place in iron and ferritin accumulation. It's called the root cause RCP root cause protocol. You can find it free online.

Yes, well I think those are really good ideas.

To incorporate both for longevity and for cancer prevention. But it also has to go on to. I think the thing you've been talking about recent, more recently, and that's the talk about.

Being emotionally stressed.

Yeah. And when particularly lack of connectivity.

Yeah. Right. So all, all those things that we also know have some connectivity with longevity. But at the same time.

To today, do you want to talk about what you're doing today?

Absolutely. Sure. We can talk about anything.

Yeah, yeah. So. So we're in fight or flight.

Yeah.

So you're measuring it on, on your people.

You're coaching with heart rate variability.

Yeah, yeah, yeah. So. And most of us are most successful people are running in a sympathetic state. And that's what makes, that's part of why you're successful. But to modulate your parasympathetics up and to be the equivalent of what some of the masters feel are a thousand hours of meditation in 90 seconds.

And I want to, I want to come to my defense real quick. And a lot of people think I'm driven, hard charging, high achieving, sympathetic. My HRV is extremely. No, high.

High. Sorry.

Yeah, it's. I, I actually, actually am not very stressed. Despite being a driven guy.

Most of my stress factors, from brainwave production to HRV to heart rate to body temperature, I tend to have very high readiness scores. But I also do a lot. I do like vagal nerve stimulators and meditation and yoga and cold plunges and every single day paying a lot of attention to nervous system, system balance.

And I, and I believe you. I mean, I know you well enough to know that that's what you're saying is true. You could also sense it in somebody when, when they're just out of, out of sorts. Yeah, but the stellate ganglion block that you're going to get today will.

Will modulate it even further and we'll, we'll see what the subtle effects are. So we know one of the reasons, at minimum, that you, you're going to benefit from it is we know that people, particularly the Navy SEALs, have been studied the most. They get stronger, they're. The recovery times decrease.

After doing a.

Stellate ganglion nerve block.

So they, and that, and you know, they're massively disciplined people as you are, and they're exercise, they're doing a lot every day and pushing themselves to the limits every day. And, and, and they, they have documented the metabolic effects and the efficiency effects of musculoskeletal on the musculoskeletal side and VO2 max goes up, so on. So you get all those benefits and some of the World class athletes that Dr. Tierney talks about a lot. They know to come in for their next stellate block when.

They'Ve been leading the world in their fields for a long time. And then as they get closer to, as someone comes closer to them then they know it's time to get their next stellate block and they get pushed further. So, so they're back to being 100 meters ahead.

It's like block doping. Yeah. And that, that's just an injection that, that triggers the vagus nerve to, to rebalance.

Right. But it's, it's unsafe when it's done in, in the wrong hands.

Yeah. So I do have to say, say that I actually have found a great deal of success with what would be considered the baby version of that, which are just these vagal nerve simulations. I have one called a, a pulsetto that I use. There's another good one called the Tru Vega. But yeah, those are, those are fantastic at home devices for, for some of this nervous system modulation via the vagus nerve.

So just for your audience to understand that, I've chosen a stack of testing that does biomic tests, lymphocyte reactivity assays to 180 or 200 foods to see what you're acting to. Heavy metals, immunological studies. They're expensive. And I think everyone is shocked and surprised by saying when insurance doesn't come in, it may cost 5, 6, $7,000 just for the studies.

Wow.

To finish, to do a job. And of course the older you are.

I'm concerned just a little bit more. But I don't leave anything unturned. Right. So for you, the first time we saw you, we didn't run every test known.

Right.

But that's quite expensive and we don't that that's what it costs.

Yeah.

To do the right thing. And then serially over time what we'll do is we'll identify a landscape for you and say this is the hierarchy of the things you should worry about. These are things you should measure two, three times a year. And this, what you're depleted in this what you need, you know, for now. And then you probably repeat some of those tests a fraction of those tests once or twice a year after that. And that's an investment that you do again once when you're younger, big investment. And you do it, you repeat it again five years later and so on.

Yeah. Well what I like about this is it's a lot of pretty simple tests from the get go that you're recommending some basic protocols like your gut biome, mold, parasites, viruses, C reactive protein, hemoglobin A1C, urine pH, vitamin D, glucose. I've got some very helpful notes here. And then like we were talking about earlier, it's kind of a multimodal approach, especially if you're concerned about being young, your risk of cancer and a lot of these preventive strategies. I do recommend for anybody listening, that book I just finished that I mentioned, Anti Cancer Living, which is also the book that talks quite a bit about connectivity. That's fantastic. Like I mentioned, Nasha Winters is another resource that I've delved into quite heavily. She's good for you. I'll of course link to your website in the shownotes@bengreenfieldlife.com cancer episode. But generally someone could just go to Anuttara Medicine, you have a new patient form or something like that if people.

Are interested in and ask for.

That. You're interested in the cancer prevention type.

Of stack of things, the cancer prevention stack, the cps. All right, cool. Avi, as usual, you're a wealth of knowledge. I always learn a ton when we sit down and make the mics hot. So thanks once again for coming to the rescue for everybody who's been asking me all these questions about cancer screening and cancer treatments.

You're welcome.

I appreciate you man.

You're welcome, Ben.

All right folks, I'm Ben Greenfield along with Avi Herkovich from Anatara Medicine, signing out from BenGreenfieldLife.com cancer episode. Have an amazing week.

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