How To Microdose GLP-1 (& How To Make Eating Less EASY Even After You Stop Your Peptides) With Geoff Cook of NOOM

My name is Ben Greenfield, and on this episode of the Boundless Life Podcast, the side effect profile of GLP-1 is really problematic for a lot of people.

8 out of 100 people after 3 years are still on the med. The data is quite clear, you're not going to be on this medication forever. So why dose up to a dose that potentially makes you sick, and that when you then remove, that food noise is just going to come roaring back?

Welcome to the Boundless Life with me, your host, Ben Greenfield.

I'm a personal I'm a personal trainer, exercise physiologist, and nutritionist, and I'm passionate about helping you discover unparalleled levels of health, fitness, longevity, and beyond. In this episode, I interviewed Jeff Cook of the company Noom about GLP-1 microdosing and the landscape of peptides and drugs in general, if you kind of want to wrap your head around what microdosing is and how it works and what to look for, this one's for you. All the shownotes are at BenGreenfieldLife.com/NoomPodcast, N-O-O-M Podcast. Here we go. My guest is Jeff Cook. And Jeff is actually immersed in something that is a big topic in America and the rest of the world right now. And so, I'm pretty interested to hear his take on this topic. He's a serial entrepreneur. He is a longtime public company CEO. He's led many successful ventures, but the one that we are going to talk about today is this company called Noom, N-O-O-M. O-O-M. One of the things that Noom specializes in is providing microdoses of GLP-1. Now, I know that you've probably, if you've been listening for a while, kind of heard me talk about GLP-1 before, and you've probably heard me talk about microdosing it, but I haven't really taken a deep, deep dive on a podcast besides one that I did a few months ago with Dr. Tina Moore. That's going to be a good one to listen to in addition to this one if you want to really be a smart cookie about the landscape. All of the shownotes are going to be at BenGreenfieldLife.com/NoomPodcast, N-O-O-M Podcast. Jeff, welcome to the show, man.

Thanks for having me. I'm excited.

Yeah, yeah. Okay. So, I got to get this out of the way right away. I kind of briefly described what Noom is, but how do you describe Noom to people?

Sure. So Noom's a leading preventative health platform. You know, we're best known for weight loss, known for— it's not a diet, it's a mindset. So this kind of whole person holistic approach to weight loss. We've been recently broadening beyond weight loss into broader health and longevity generally. And so it's actually microdose GLP-1 that we view as kind of the front door to healthy aging and longevity and allows us to, to really expand into the longevity category. The way we define our mission is our, our mission is to empower everyone everywhere to live better, longer every day. And so we come at this concept of longevity not through this concept of healthspan, which can be an abstraction to a lot of people who are not, you know, real optimizers, but, but through the lens of vitality, you know, feeling better today. And what are those things that can help you feel better today but then also lead to longevity tomorrow?

Right. Get out of bed without pain versus live to 200 years old. Exactly. Yeah, I hear you. Okay. So first of all, and I kind of want to hear your personal experience with this stuff as well, but just laying the foundation so that we get some terms and definitions out of the way here. How would you define a microdose of GLP-1? And I would especially kind of like to hear that contextualized between, between the microdose and what you'd get if you go to the average doctor and just get a GLP-1 prescription for a standard dose?

So we have a pretty broad definition of microdose at Noom. Um, there is no agreed-upon, uh, dose and, and that, that qualifies as microdose. It, it's— but the way we use it is 2% to 25% of the high maintenance dose that you would typically be on for these medications. So Okay, um, 2% to 25%. 2% is quite small, so that would be, um, you know, on semaglutide, that would be, uh, I, I believe 0.05 milligrams. Um, you know, 25% would be closer to 0.6 milligrams.

Okay, so then a standard dose roughly would be 2.4, like 5, 5 milligrams-ish for like a large standard dose of, uh, of semaglutide?

So, yeah, the high maintenance dose of semaglutide is 2.4 milligrams.

Okay, 2.4.

Yeah. So, 0.05, you can see how much smaller that is, right?

Yeah, it's a lot smaller. 50 times smaller. Yeah. Yeah. I mean, my own personal history, Jeff, is even though I don't use a GLP agonist right now, frankly, so long story short is I microdosed with retatrutide for about 8 weeks. That's kind of a triple agonist. And maybe you can explain what a GLP-1 is versus a GLP-3, for example. And standard dose of that is 2.5 milligrams. I was taking about 0.25, so around a tenth on a Monday, Wednesday, and Friday. I felt great. I kind of liked the quieting of the food noise without the complete suppression of appetite. And then, I decided I wanted to get into a muscle gain phase and I just wanted to be voraciously hungry at every meal. So, despite some of the pleiotropic system-wide benefits of something like that, I kind of cut it for a little while just so I could put on some muscle at a faster pace than I might be able to if I was kind of quieting the food noise. So anyways, back to the microdose thing. So, You said it's about 2 to 25%, and at Noom, you guys are recommending semaglutide. And that kind of leads to what I just alluded to. Why semaglutide versus any of these other ones that are out there where there's like 4 or 5 of them, right?

Yeah. So we prescribe, you know, generic GLP-1, we prescribe compounded GLP-1, and we prescribe branded GLP-1. So we actually have a pretty broad formulary. We don't prescribe anything that's not been through the FDA process, so it has to be either FDA approved or compoundable in a 503. So that wouldn't include some of the more recent compounds that may not be approved yet. You know, I, I also have a history of microdosing. I've been microdosing since, since about a year ago actually. And, um, I was doing it in part because, you know, I'm a product CEO. I believe in kind of eating your own dog food, so to speak.

And I was going to build this feature, or at least microdosing with your own dog food.

Exactly. Um, and I was, um, taking some of the blood tests that we're, uh, planning to, to launch soon, um, and was kind of concerned that my A1C was actually quite high. Uh, it was 5.6. And, um, you know, I, I knew I had some weight to lose, um, and so I, I, I thought, well, you know, this is a great excuse, let you all be kind of the end of one here. Um, and it was a profound improvement in A1C. So my A1C went from 5.6 to 5.3. Um, what was interesting was I, I started, you know, I, I just naturally started avoiding snacks that, um, I previously may have gone to. I lost 10 pounds. I started working out more instead of a few days a week. I'm active every day now. And so, I felt like habit stacking became easier for me. And I've continued to do it more or less every week. And I take the weekly injection. I know you were doing it every couple days.

You're doing weekly semaglutide? Yeah. Okay, got it. Now, you said something interesting about the compounding pharmacies and this fact that you guys don't use anything that's not, I think you said, approved for production by a 503 compounder. Is that what you said?

Yeah, yeah.

And so, does that mean that there are certain GLPs that you can kind of still get and have made by a compounding pharmacist and others that you can't?

Yes. So there's some of the newer GLP-1s that, you know, you might be able to find that are kind of research grade, which we wouldn't suggest anyone do. Um, but they're, they are available, you know, on, on websites, um, not at Noom. Um, but, um, the, the, the way the regulatory framework in this country works for compounding is it has to be compounded by either a 503 or a 503 compounding facility. And those facilities have to, you know, are either state regulated by the Board of Pharmacy. Um, there's requirements that they, they get the active pharmaceutical ingredient, like the actual, you know, semaglutide or tirzepatide, that they, they get that only from a green-listed, by the FDA, green-listed provider. And so there's just more regulation and scrutiny, um, than going, you know, a kind of, uh, out of that system.

Ben Greenfield: Okay, got it. So, you guys are using semaglutide because that's one of the ones you can actually have made by a compounding pharmacist and thus you can have it made in any dose that you want? Yes, correct. Okay, okay, got it. Do you think that there's a chance that there will be some type of a restriction of even things like semaglutide? I don't know what the pharmaceutical landscape is right now in terms of lobbying efforts or FDA regulations are looking like, but holding a crystal ball, like, are you concerned at all? Do you think you'll just be able to continue to work with a compounder?

It's a good question. You know, I think I was at the Maha Summit pretty recently, so the Make America Healthy Again Summit. You know, many different academics were there, different industry people. The vice president spoke, RFK Jr., the health secretary. Dr. Oz, and among others. And what struck me— and this was only last month— what struck me about that was no big pharmaceutical company CEO was, was, was on stage at the event. They, they didn't seem like they were invited. But the, the person that spoke, or the panel— there was a number of speakers who spoke directly after the FDA Commissioner Makary was a 503, a 503, and another kind of, uh, somebody in, in the compounding business. And so, you know, it, it's— I, I don't know if that's reading tea leaves or not, but, but it, it seems to me this administration is quite, um— they've, they've recently come out with this FDA green list concept where, um, 503s must and bees must, must source their API through greenlisted providers. And that was widely thought that they were doing that, uh, to help, you know, ensure that there's a quality bar with respect to compounding. And so if you were about to stop it or restrict it, you wouldn't need to take steps like that. So, so people in the industry generally thought that was quite positive. Um, So, so, you know, I, I think you, you just never know to some extent, but, but I, I do think that, um, uh, because the administration seems to want access to medications affordably and has really been making that a push, um, that because the, the compounded medications are typically the most affordable version, and if you can drive some quality to keep that, uh, safety profile reasonable, That seems like their approach, but you can't obviously speak for the regulator.

Yeah. I think some people aren't even aware of what the cost would be. I mean, I realize you've got plenty more to fill you in on what your company does and this might be putting the cart before the horse, but let's just say somebody wanted to start microdosing with semaglutide, how much approximately would it cost them per month?

Noom, it's $99 to start, and that, that, that's the first month, and that includes the doctor's visit, the prescription, and then the new behavior change program. And then, and then it's $199, so it does go up in dose, um, but, but then it stays at $199. Um, and, and that is actually fundamentally different. What, what Noom does, it's quite different than what other providers do in our space. Is the behavior change bit. So on our Microdose program, 40% of, um, the monthly users are using the behavior change program every day. So they're actually active in the app every day, 40% of the monthly users. So it's actually quite, uh, and that engagement or that behavior change program is really aimed at driving movement, get people moving, uh, resistance training, get people— there's a muscle defense aspect of that, try to prevent Muscle, lean mass loss, nutrition, of course, protein intake. You know, I felt this really manifestly when I started taking the microdose myself, was like, wow, you know, I can really understand how people might not get enough protein because if you, if your eating habits were already quite poor and instead of eating a half bag or a bag of Doritos, you eat half a bag, but now you're, you're full for 6 hours. You're not going to get your protein target.

Ben Greenfield: The idea of that kind of appetite suppression is really a good point. Like I mentioned, I just stopped cold turkey microdosing to put on extra mass, like super physiological mass more than I'd be able to just eating a slight amount of excess calories. And, I just wanted every advantage I could get in terms of not shutting down appetite, but it is a good point. So, It's kind of just a little bit of resistance to eating and it therefore requires just a certain amount of self-awareness when you're sitting down to consume a meal, especially for, as you noted, the protein piece. But, it's nowhere near because before I did the microdose, Jeff, I did full dose just to see what it felt like. And, I was nauseous and I couldn't eat for a while. I mean, I could eat, but it was like force-feeding and I could get down maybe 800 calories a day for 3 or 4 days in a row. And, I didn't feel well and gastric motility slowed, so I was constipated. And then, once that wore off, I had diarrhea and just did not feel well on that standard dose. And, I know people gradually get used to the standard dose, but the microdose is still something that you got to have self-awareness around with food, but it's way different than that megadose that completely shuts down appetite and then you don't want to go to the gym, right? It's like you hear people say, well, eat enough protein, go to the gym. But when you can't even eat calories, much less protein, you're flat when you go to the gym. And so it creates kind of this negative feedback cycle.

Yeah, I do think there's something to that. I did a half marathon recently and that was one of the weeks I skipped because I did not want to to have any kind of appetite suppression ahead of, ahead of that. Um, but I, I would say the side effect profile of GLP-1 is really, um, problematic for a lot of people, right? Like, it's, um, when you look at, at how many people actually stay on the medication, it— there was a recent study by Prime Therapeutics, um, it showed only 90— or showed only 8 out of 100 people out after 3 years are still on the med, and only, I think it was 15 out of 100 at 2 years. So they just keep kind of falling off. And so Noom has obviously been doing behavior change and dive for, for, for well predating, uh, the recent GLP-1. Um, but the way we look at it is if most of the people who start on a GLP-1 with us or with anyone are eventually going to come off of it And so the trick for us is how do you use the GLP-1 to spark, you know, a window of change? Like, basically the GLP-1 opens the window where you're going to be able to get weight off quickly, and it's going to be more than you've seen in the past. You've probably someone who's struggled with losing weight in the past, and if you're combining that with the healthy habits, um, that what we've always noticed is the people are most likely have success are the ones who have had early success. And so, like, you know, success begets success. And so we use the GLP-1 to spark that journey. I, I— those habits over like 2 to 5 months become an identity. And then, uh, you know, ideally that's how you produce change at last. So like, that, that's, that's the aim of the program and why we've wrapped microdose in, because our view is like, look, your odds are— the data is quite clear— you're not going to be on this medication forever. So why dose up to a dose that potentially makes you sick and that when you then remove that food noise is just going to come roaring back? So we, we, we, we really emphasize the microdosing aspect.

Yeah, it's the training wheels type of concept. And I think you can kind of look at it two ways, right? That you can look at it the way that you just described where, okay, you're using this to realize what it means to eat less, to set up good boundaries, to begin to kind of create habit loops that you can sustain on the microdose that then you should be able to sustain off the microdose once they're kind of cemented in place. And then, there's the flip side of— and I would love to hear your thoughts about this— the people who get on the GLP and kind of view that as the magical injection that's keeping them from eating too much. And then, once it's no longer in their fridge and they're no longer injecting, they feel like they don't have their superpower anymore and they start to eat more again. I don't even know if this has been researched or if you see a difference in weight regain with certain things that are followed like certain habit-building mechanisms or whatever you do at Noom. But, what are your thoughts on that kind of parallel in terms of how people actually respond or think about it psychologically?

Yeah. So, it's interesting. If you look at the data coming from the pharmaceutical company's own studies, they show very rapid weight regain on med discontinuation, more or less to the point where you regain it all over something.

That's with, that's with a standard dose, right?

That's with the standard dosing. And also, those studies are all done on very high BMI populations, so they're, they're, they're kind of cherry-picked in that, in that regard. Um, there was a study by the EMR, uh, EPIC, that, um, looked at this in a real-world population, and it actually found about 50% of the people at a year kept post-discontinuation, kept the weight off, which was, you know, I think eye-opening for a lot of people who didn't think it could be that good. Um, with Noom, um, we believe it should be higher still. Um, so, you know, we're, we're putting together that data. We'll definitely publish it in, in this, this, in, in '26. Um, but, um, there's some another behavior change program that's worth looking at called Embla. They published their data recently out of Europe And they, they showed extremely high, um, uh, uh, kind of weight maintenance at a year, um, when the behavior change was actually built as part of the program.

What's that mean, to build behavior change into the program?

So, I mean, most people, by far, you know, most people who, who begin on a GLP-1, they're getting it from a doctor or from some online clinic. And that's it. Like, there is no— they may think they're going to try to do something differently, but there's no built-in structure. There's, there's nothing they're, they're necessarily doing. Um, with respect to Noom, the way we, we think about it is like, in inside of the Noom application, uh, we're giving you tasks every single day to hit, and you, you check them off. And, you know, that, that might be a protein, uh, objective, uh, a step goal, even mental health aspects, like an art therapy bit. But you, you're doing your daily tasks, and we find that people actually do them. And, you know, 40% of people are doing them every day. And so, like, if you're, if you're providing and doing the structured stuff, then you're going to be more likely to actually— for that habit to become entrenched, because we think it takes like 2 to 5 months for a habit to really get entrenched. And so, we take it from let's get you to do the micro habit, the littlest thing we can chunk and then start building up from there.

Ben Greenfield: Okay, got it. There's at least a dozen listeners who are putting on their tinfoil biohacking hats and thinking about downloading the Noom app and combining that with their sold for human research only chemicals from some other peptide company. I guarantee you. But that issue aside, we've talked a little bit about weight loss and appetite suppression, Jeff, but what are— and I use the word pleiotropic or system-wide effects earlier. What are some of those effects that would go beyond appetite control or weight loss that are good?

Yeah. I mean, so there's heart health effects, right? The studies suggest cardiac muscle improvement. I think that was in heart attack victims. Um, but, but cardiac blood flow seems to be, uh, impacted by, uh, in a, in a good way, um, by semaglutide. Um, the inflammation change for, from, from these medications, um, is a clear reduction in, in, in, in inflammation, often shown through, you know, the high sensitivity C-reactive protein biomarker, which falls markedly in the first few weeks, you know, before often there's any weight loss effect. And that inflammation can, you know, show up in, uh, you know, your knee trouble resolves. Um, and it, you know, it's— I think it's more complicated than saying, well, if you lost some weight, so of course your knee problem resolved. It, it's, it's that the, the underlying inflammation is going down and you lost some weight. So it's actually improving in, in multiple ways. Um, inflammation may well have something to do with Alzheimer's. There was a recent Alzheimer's, uh, kind of a report with respect to semaglutide that didn't, uh, look as good, but that, that was in folks with, with, uh, I think more advanced Alzheimer's who are actually in the disease. Um, there's this viewpoint that, um, you know, once the disease pathways get going, this may not be something that stops it, um, but it may be the sort of thing that, that helps if, if done more proactively um, earlier on. Fertility and PCOS is— is there's, there's data showing improvement there. And then, you know, basically the reward center of the brain is, is, uh, being addressed by, um, the, the GLP-1. And, um, so, you know, alcohol abuse disorder, um, addictive gambling, even, um, those sorts of behaviors have also shown improvement. And I think there was a study by a guy named Zhi who, who looked at, um, who looked at that. But, you know, I, I, it's— they're extraordinary medications. And, you know, I, um, I've, I've been dabbling, uh, I'm doing a— on the side, a, a Master of Science program at Tufts in, in their nutrition school. And what I came across this, this recently was this study that basically showed, um, in fMRI. So, so people were, were in an fMRI scanner, um, and there was a basically a chocolate milk study, and they found that the GLP-1 increased the, um, liking for a food but decreased the wanting.

So wanting went down but liking went up, which is very odd because you'd assume with a dopaminergic response both liking and wanting would increase.

Yeah, yeah, it was remarkable. And when you think about like, well, what the disease of obesity might have, uh, associated with it, you know, it is this thought, well, you eat but you're not satiated, so you're— you want and you crave, but then you eat but you're not satiated, so you eat more over nutrition, right? And so if the GLP-1 seems to, um, decrease the, the craving, decrease the wanting but then also increases the liking, which is remarkable. Now, of course, I'm sure that has something to do with dose. I'm sure if you, if you just saturate your reward pathways with GLP-1, you probably could affect both.

There'd be a point at which the no-liking mechanism would kick in. I would imagine it's kind of interesting how there's a lot of tendrils that snake throughout the, the, the biological system from some of the things that you described. It's like, well, you lower inflammation, And yeah, you're going to potentially reduce joint pain, reduce inflammatory cytokines, but also it's a pretty well-known fact now that inflammation inhibits fat cell autophagy. So, once you've shut down inflammation, you've got a double whammy on fat loss because fat cells are mobilized to release more fatty acids and you're also eating less, so you're emptying them out more quickly. Filling them up less quickly. Or, with something like brain health, not only would I say dementia is related to inflammation, but of course, also glucose utilization by the brain. And maybe if you're eating less, you are burning more fats as a fuel and you're creating more ketones as a byproduct to burning those fats. And thus, the brain has an appreciable source of alternative energy to glucose. So, you've got less less glucose being utilized by the brain, more stable pathways. So yeah, you can kind of see how there's a lot of ways that these things kind of weave throughout the body.

Absolutely. You know, just, just picking food noise for one, right? Like there's this question of, well, what is food noise? And, you know, the best theory I've heard is basically the default mode network of the brain, which is what your brain is doing when it's not doing something else, which people are generally in half the time. It's generally always simulating futures, futures, right? So like, what, what am I going to do next? What am I going to do? And that, that could be the source of anxiety for some. Um, it's implicated in depression, depressive disorders. Um, but food noise is basically maladaptive thinking about the future, prospection. Um, and so what happens when you're not spending 50% of your time or some, some high portion of your time thinking about your next meal or that you're hungry, um, what do you— what does that free up cognitive bandwidth to then go and do? Um, and you know, we're, we're looking at this from a research perspective. We have a research team here, but we were curious, like, does it increase naturally mindful behaviors, right? Like, are you just— do some— is it my— is it a mindfulness shot in some regard? Does it enhance mindful behaviors if, if they're, if they're done alongside of them? Um, so, so like, what, what exactly, um, you know, is the, the decrease in food noise— what might that be freeing up cognitive bandwidth to do? It seems, because many people do begin a health journey or deepen it, that if you're not constantly thinking about food, that, that may allow some positive prospective futures. So things like, you know, my habits, or, um, you know, I'm gonna work out a little bit more. And so like, that, that does seem to have some something there, but we're trying to, um, show that. Uh, so, so that, that'll be— it'll be— we're curious to see it.

A significantly high percentage of the high performers I know, um, on their busy days set up some type of system or environment in which they're eating less, basically fasting on the most demanding days for productivity. I had a 36-hour fast last week and obviously, my most productive day of the week was that 12-hour span where not only did I have a solid 3 extra hours from not preparing and sitting down to a meal, but also just the focus when you're not thinking, which is another significant number of minutes. About the next meal or the meal that you've just had. So I can see the banners now at Noom, you know, increase productivity, make more money, get a better career, get a raise. There is something to that, though. The reduction of food noise goes beyond just eating fewer calories.

I was just going to say, you know, like Noom is this mindful eating program, right? And so like we came at it from the point of view of food noise could be handled through mindfulness, right? And so like, if you become aware of your kind of interoceptive body cues, um, you can notice that you're feeling a hunger pang and, and then kind of dismiss it or, or, or, or reorient the brain. Um, you could handle it in basically a top-down way. And then with the GLP-1, we see that as a more bottoms-up, you know, it's changing your reward pathway., and so you're, you're, you're, you're just not as allured by that bag of chips as you used to be. And so if you combine those two things, you get some— you can really get a lot of power out of that, in part because what the GLP-1 may not help with as much is like stress eating, right? Like if, if you're eating because you're not, um, because you're feeling some kind of stress or it's a psychological eating, it may not be affected by your reward pathways. So, combining those two is actually quite helpful.

Yeah, yeah. Some people might be concerned about the safety piece. You talked about these confounding pharmacies and how they do have certain hoops they need to jump through that sold-for-human-research-purposes-only companies do not. But, if someone's sitting back thinking, "Gosh, I heard my friend had low blood sugar or some kind of shock or sepsis-like reaction when they injected a peptide. I'm scared. I don't want to go through that." How do they know that your peptides are safe? What do you look for to know if something like a microdose is safe?

For one thing, they're compounded in this regulatory framework the 503, which is, um, I think it was the Food, Drug, and Cosmetic Act that, that from that, that set that up. Um, and those companies, those 503s can only use the API of a green-listed provider, and they have to have the certificate of, uh, authenticity, the COA, on file, um, attesting to the purity of the, um, the API. And then when they compound it, they do it in batches, and, and each batch is sampled and then sent to a third-party test, uh, which then, um, only releases the batch on, um, that batching, you know, that, that, uh, test being concluded. Um, and so, you know, this is, this is some of the, the key ways, uh, you know, we We try to do everything we can to be in compliance, but the other way is just how we dose it. So, a lot of the side effect profile of the medication is related to maybe overdosing the med or your body just doesn't need as much. So, we have this low— we call it the low and slow titration protocol where we'll start people very low on a microdose program our lowest start could be as low as 0.05, um, and then we only titrate up based on a combination of, uh, BMI— your BMI— as well as your side effect profile, um, and, uh, your, your kind of desired BMI. But what we're trying to avoid is you losing, you know, more than 2 to 3 pounds a week. Like, when you lose weight too quickly that's when you get more of that weight. And studies show this, when you get more of that weight coming off as lean mass. And so the— we, we call the titration schedule— we use SmartDose. But, but in any event, what it's meant to do is minimize or, or find a healthy balance of, uh, of weight loss speed. So we're not actually trying to get you to lose weight as quickly as possible. We're trying to do it in, in in a sustainable way and one that is designed to minimize side effects.

Ben Greenfield: Yeah. Okay. So, if I were doing a normal peptide in one of those little bottles, I might pull it back to whatever tick mark I've been instructed to do. Let's say it's a 15-tick mark on a 100-tick mark insulin syringe. And for a lot of people, I don't think they quite understand how important it is to very precisely use that reconstitution liquid when you reconstitute and know the dose that you put in there. And then, when you pull back, some people will be like, "Well, it says 15 ticks. What harm could 5 extra ticks cause?" And, that can be the difference between getting the effects you want and heart rate racing, flushing, irritability, collapsing in bed, et cetera. And so, I actually don't know the answer to this question, but I'm guessing You have some kind of preloaded pen or dose delivery that goes beyond just pulling it back into an insulin syringe?

So, we have a vial and it's a liquid. You don't have to reconstitute, so there's no powder. And, what we do is as part of the SmartDose procedure inside of the application, it tells you what your next titration step is and it will actually show you the the syringe and where exactly you're supposed to pull it up to because people do have this issue with, well, how many units, milligrams, it could be a lot for someone to understand. It was like, fill it up to this line. That's much easier for people to understand.

Ben Greenfield: Right. Okay, good. Yeah. And again, if you're listening, please, word of caution. I think some people don't realize when you're dealing with micrograms, there's a big difference between the 20-tick the 5-tick mark and the 15-tick mark. So, that's good that you guys include those instructions because I see people making a lot of mistakes there. So, with Noom, you've got the app and I get my peptide. Is that shipped to my house or do I need to go pick that up from a pharmacy?

Yeah, it's shipped to your house typically within about 7 days of filling out your intake.

Okay. Alright, got it. And then, I was actually curious about the whole blood testing piece. Obviously, a lot of people are going to want to know beyond just say appetite regulation if it's working. You mentioned your hemoglobin A1c went from 5.6 to 5.3, which is great. For people listening, that's just a 3-month snapshot of your average blood glucose levels. And sometimes, it's better than just a single blood glucose reading. But what do you guys do about, I guess, like testing or tracking, you know, uh, what's going on in someone's body when they're using your product?

So we include labs with all of our GLP-1 offerings, but, but what, what's most interesting is, is actually what, what's coming out on Monday. We have, we have a big announcement, and, um, it'll be the first time where we're wrapping in to the microdose program easy at-home labs. So, um, we actually will send you, in addition to the medication, a Tasso device, which is, uh, yeah, you know, it's— yeah, it's cool, it's a cool device. And so you put it on your arm, you hit the button, it's virtually painless, it collects, uh, you know, a little vial of blood, you put that, um, in the FedEx, and you get your results back, you know, typically a matter of days.. And then every 4 months you'll get another package. And so instead of just waiting, you know, a year for your next physical, um, you can actually, uh, see the, the what, you know, kind of how your health is transforming based on both the habits, um, and the GLP-1 program. And so, you know, we're thrilled to, to kind of see that data. You know, it's also just going to be an interesting data set, um, from a point of view of you know, really seeing what low levels, what microdose levels of GLP-1, how it impacts, um, blood work and ApoB, Lp, A1c, you know, there'll be 17 biomarkers. Um, it's, it's a small quantity of blood, that's why it's not like 100 biomarkers, but it'll be done regularly.

Yeah, so basically your general markers of, of lipid and metabolic health.

C-reactive protein, or high sensitivity C-reactive protein, is in there, uh, a measure of inflammation. Um, we also get, uh, testosterone, uh, free T.

That'll be interesting to see, like, the, uh, the endocrine response to GLPs.

Yeah, no, it's, uh, at least in my own blood work, um, you know, I saw a pretty significant improvement across the board. But I would say what improved the most was, um, the A1C and the triglycerides. Just like, it's like unbelievable how quickly that, um felt, C-reactive protein did too. Things like cholesterol, I think that's harder to move. I wouldn't necessarily expect to see that.

Ben Greenfield: Yeah, it kind of depends. I mean, you do tend to see an uptick of cholesterol as a way to battle inflammation in the body of someone who's inflamed. So, if inflammation drops, you would expect some kind of a drop in total cholesterol levels and probably back to your measurement of testosterone, inflammation can also suppress the metabolic activity of the Leydig cells in the testes. So, I wouldn't be surprised if there was a little bit of an impact on testosterone as well. This TASSO device, by the way, if you're listening to what Jeff is describing here, it's like this circular device that you stick, for example, on either shoulder, then you put a little tube on the end of the device that you stick to your shoulder which is smaller than a cell phone, and it just drips the blood into the tube, take the tube off, put it in the bag, and send it off. I don't know if you guys do this, Jeff, but the ones I've gotten in the past have a little heater that you put on the shoulder to get blood flow first.

Yep, we do. We have that. It's actually important to have that. We used multiple different heaters. The first one wasn't hot enough and the blood didn't come out in our testing. And so, we had to upgrade our heater pad.

Ben Greenfield: Yeah. Tip for those of you who do home blood testing, now any morning I'm doing a test, first thing I do when I get up is I go turn the infrared sauna on and then I bring all my testing equipment in there and do my blood draw, my finger prick or my tasso inside the sauna. And, you fill up everything way more quickly when there's a little bit of heat going on. So, the other thing I noticed, Jeff, on your bio and this Noom announcement that came through is that you guys are working on getting Big Pharma to actually lower drug prices without a law or a new regulation. I didn't really quite know what that meant, but can you describe what you guys are doing?

Yeah, sure. So, for more than a year, we've been pretty vocal on the issue of drug pricing, in particular that until recently, the price of these medications were maybe $99 in London and $499 in New York. Um, and the— we actually took out multiple Wall Street Journal back covers, um, basically proposing, uh, a high-priced drug list. And so if, um, the pharmaceutical company— so the way that the, the drug regulation works now is a 503 pharmacy which can compound an enormous amount at a, at a very large scale with great safety parameters Um, but they can only compound when something's in shortage. And so what's— what we proposed was, well, a medication is effectively in shortage if people can't access it. And if the price is higher than some basket price, let's say 2x the price of, you know, Western country, uh, drug prices, well then let the 503s compound that medication because that will basically provide an escape valve for, you know, more or less an otherwise broken system, right? Because the drug company is really just exploiting their monopoly, their patent monopoly, um, and that's fine. You know, there should be some capability, of course, to get paid for innovation, but at some point you're gouging the public, right, if you're, if you're 5, 10 times more. Um, so what we have seen is the prices have started to come down, but they are still quite a bit higher. And so, you know, we'll continue to call for those prices to fall, but we're generally just on the side of access to GLP-1s because ultimately we want to wrap our program around whatever GLP-1 people can take. And then ultimately, you know, the more affordable the program, the more people will consider it.

Okay. So this 503, I'm saying that right? 503? Because this 503 pharmacy could make a drug if that drug were in some kind of a shortage or if there was increased consumer demand for it. But, for them to start doing more of that, there doesn't have to be some kind of new law or regulatory adjustment made?

No. Our interpretation is simply that HHS, Health and Yeah, the HHS secretary would just have to, um, say that when they def— when they look at demand for the drug, they're evaluating the demand at a given price, which I think makes a lot of sense. Like, how do you— how do you determine demand if not at a price? Um, and so rather than just let the drug manufacturer say, well, it's not in shortage, see, you know, nobody's buying it at $1,000 a dose, You can say, "Well, you're charging everybody else $100. What would the demand be at that dose?" Right?

Ben Greenfield: Yeah. There's a huge lineup of people who would love to buy it at $100 or $200 compared to the $1,000 it's currently at. Okay, that makes sense. Interesting. Jeff, this is pretty cool what you guys are doing. I really like how you are including the app for the behavior change component, which I think is missed a lot of the time. Not that I want to cheapen what you guys are doing, but it's almost kind of like McDonaldizing the easy process of getting what you need from a microdose GLP standpoint in kind of a predictable and easy way. So yeah, when I heard about you, I knew I want to get you guys on the show. So, this is pretty interesting stuff. And, Noom gave all of us, I think it was a 10% discount. I'll link to that in the shownotes at BenGreenfieldLife.com/Noom. Noom Podcast, N-O-O-M, Noom Podcast. You can leave your questions and your comments and your feedback over there as well. I read all of those. And Jeff, thanks so much for doing this, man.

Well, thank you, Ben. It was absolutely my pleasure.

Appreciate it. All right, cool, folks. I'm Ben Greenfield along with Jeff Cook of Noom signing out from BenGreenfieldLife.com. Noom.com/noompodcast. Have an incredible week.

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