Is Methylene Blue The Key To Lasting Vitality? Defying Disease, Revitalizing Cells, And Safeguarding Your Prostate From Cancer With Dr. John Lieurance

My name is Ben Greenfield, and on this episode of the Ben Greenfield Life.

Podcast, there's been some studies showing that both silver and gold and methylene blue even further enhance this whole photodynamic. It's called photobiomodulation.

And you're talking about, like, oral silver and gold. You take it orally?

Well, the protocol we did in the clinic, we did IV silver. And then we have a gold that will have people nebulize, or we'll put it in their eyes. We'll do intranasal gold. And so that's the delivery we do right before we run the methylene blue. And then we do the intravenous red.

Light fitness, nutrition, biohacking, longevity, life optimization, spirituality, and a whole lot more. Welcome to the Ben Greenfield Life Show. Are you ready to hack your life? Let's do this.

All right. So it's been a crazy past few days. I showed up in. In Sarasota, Florida, and I. I always know that I'm in for a wild ride when I arrive here because it is the haunting grounds of my friend Dr. John, who's here with me. Dr. John's been on the podcast, what, like, three times? Yeah, I think before the first time, he arrived at my house and showed me all my crazy tools I could do to upgrade my body. You're the guy that taught me how to put in my first suppository. You didn't do it for me, but you gave me some friendly advice on how to do it, and that included a handstand at the very end or some form of inversion. And, of course, since then, I've been a champion of melatonin suppositories and nad suppositories. And I learned from you, I believe you call it. What do you call it? Gassens protocol. Putting things into every. The orifice of the body, which we can get into later on. Like different delivery mechanisms that go beyond just eating stuff.

Yeah.

And then, you know, I've explored all sorts of different areas with you. I'm going to link in the show notes if folks go to BenGreenfieldLife.com MagicBullet that's BenGreenfieldLife.com Magicbullet links to all of the other shows that I've done with John where you can get to know him, his background, his intriguing story a little bit more. But anyways, back to my TED Talk of an introduction here. I showed up in Florida, and John whisked me away to his clinic, where he proceeded to adjust all the bones in my skull with a cranial balloon reset.

Well, we did that eye test first.

Yeah. Inject me with stem cells. And he tested my eyes before and after to see how this was affecting my vision, this cranial balloon adjustment that he did. Stem cells. Stem cell infusion with a special form of stem cell that uses as clinic. But then, most intriguing and relevant to the meat of today's topic, John put me on a methylene blue iv, which is crazy. It's literally methylene blue under red light. And then here's the kicker. He took this big, huge, long needle and injected my prostate gland with methylene blue and with ozone. And I almost wanted to title this podcast episode Barking Elephants, because for any guy out there, just know this. If you get your prostate gland injected with ozone, you basically feel like you have to pee. But when you go to pee, only gas comes out. And so my sons were laughing quite a bit when I called them on the phone, told them that dad was farting out, as, you know what. And then John said, well, yeah, that's why we call this the barking elephant procedure. So anyways, as you guys can imagine, though, tons of very, very cutting edge and outside the box modalities that John experiments with. But what I really want to focus on today is this book. I'm going to hold it up for the camera. It's called Methylene Blue the Magic Bullet. Now, what I'm holding is the advance copy that John sent to me. If you get this book, it's not going to look like it got printed at Kinko's, but I learned so much in reading this book. I went through it when you first sent it to me, and then again on the plane ride down and people hear about methylene blue and basically the general echo chambers. Yeah, it's good for your mitochondria, bro, but there's so much more to it than that. And so the very first question I have for you, because I think this is going to be important for just setting the foundation for this show, is how do you describe methylene blue to people when they ask what it is?

Well, I titled my book Magic Bullet because.

In the early 1900s, Paul Ehrlich was a Nobel prize winning scientist, and he was the one that discovered that methylene blue was the cure for malaria. And that's what really put methylene blue on the map as a medicine.

But prior to that point, it was just like a textile dye. People say it's a fish tank cleaner.

Well, listen, so it stains tissues, right? So they used it in biology pretty regularly. And in Fact, there was a discovery where they didn't know the dendrites would grow off of neurons. And there was a famous neuroscientist that used methylene blue to be able to first discover that the neuroplasticity event when you have connections with new nerves, because methylene blue has an affinity to the mitochondria, and because nerve cells are so rich in mitochondria, those nerve cells light up a lot bluer than the surrounding tissue.

And is that why people say when you use methylene blue, a large percentage of it winds up in your brain?

Yes. And your heart.

And is that, is that true when people say that, that it actually does wind up in your brain?

Yeah, yeah. It goes to all your nerves.

Okay, okay, got it.

It goes to all your mitochondria. And so the most energy demanding tissues in the body are going to get the most methylene blue.

Now back to where it comes from. You said that it began to be used as an anti malarial.

Yes. This is the first medical indication.

Isn't that similar to what like hydroxychloroquine is?

Well, so methylene blue is the father compound to hydroxychloroquine. The chloroquine family of drugs was modeled after methylene blue. So the problem early on is they found out that methylene blue is just terrific for infections and keeping people from getting sick as well. And so they didn't like the fact that they were peeing blue. People were like, well, yeah, I like the effect, but they were complaining of the.

Now, trust me, I know. Your toilet over there. We're at John's house, by the way, for those of you wondering. And he keeps giving me different forms of methylene blue eye drops. And he's got trochees and creams and even this suppository, which is why I thought your book was called Magic Bullet. Cause the suppository shaved like a bullet. Been peeing blue since I got here. I get what you're saying.

I know.

It was all over the toilet seat. Actually, it's cleaned up now.

Yeah.

Yeah.

Well, newer, Newer toilets do better, but the older toilets that are porous, you have to be careful. You really have to be careful with staining a lot of things with methylene blue. So once you kind of figure out how to navigate handling it, the problem doesn't really come up. But you definitely have to understand that once it stains something, you.

My wife has gotten pissed at me a few times. I've stained a few things and I felt so good When I walked into your house, and within being here like an hour, I think I notice at least four different methylene blue stains on random rugs and carpets. So I'm like, okay, I'm safe. My house is not as stained as yours is.

So you can really trust an individual if you know there's a lot of stains of methylene blue because you know they're going to be neurologically stable.

That's true, that's true. It's a sign of intelligence. So methylene blue has this background in medicine as like an antimalarial, but now it seems like the popular way that people are using it goes way beyond that. So when did it first became something that you started using your practice?

Well, I first learned about it maybe 12 years ago, and I was reading about it even further back than that. Actually. A colleague of mine was running it as an IV for Alzheimer's, but back then they were using such a light dose, it was like 5 milligrams, and I wasn't seeing the result. I played with it a little bit. I mean, this might have been even almost 20 years ago. And a lot of research has been done on that. Francisco Gonzalez Lima is someone that is an authority with utilizing methylene blue for a number of indications for neurological conditions. And so I listened to, I researched some of the studies that he was coming out with, and then we started to use higher doses.

Higher than 5?

Yeah, we started using doses that were in the range of under 4 milligrams per kilogram of body weight, because that was kind of the upper limit that they found. So and we can kind of dial.

In on dosage 4 milligrams. If I weighed like 80 kilograms, you're talking about like 320 milligrams or so.

Yeah.

So a lot higher than five.

Yeah.

Okay.

Now that would be, that dose would be like a one time dose that say if you had cyanide poisoning and you went to the hospital, like literally all hospitals are required to carry methylene blue because it's the cure for really methyl hemoglobinemia and cyanide poisoning. So these people reported the hospital, they do this infusion and.

It'S a cure.

Oh, wow. I didn't know hospitals had methylene blue.

Yeah, interesting. Another really interesting fact is that blood banks, what they do is they inject a little bit of methylene blue into the blood that's donated and then they irradiate the blood with near infrared and that's how they sterilize the blood. So anybody that's gotten A blood transfusion has actually gotten a little bit of methylene blue.

Now, there was a guy that recently wrote a report on methylene blue, a friend of mine, actually, Chris Masterjohn. And in that article, he said some good things about it. He cautioned a little bit against high dosage. But one thing that stood out to me is he said it rewires the electron transport chain. Rewires the electron transport chain, which I think is an interesting way to think about it. But when you look at methylene blue, and this is something I learned from your book, it appears to have, like, this unique ability you don't see in chemistry very much to accept electrons and also donate electrons. I think you called it, like, the pleiotropic effect, right?

Yeah.

What's that mean? Exactly? They can do that. And why is it important?

So it's a pro oxidant and an antioxidant. And this magic comes from this thiazine ring. And so I think about the thiazine ring, like the catcher, right? It's able to catch electrons, and then there's something called amine, which can deliver electrons. And so it's almost like a pitcher and a catcher throwing a ball back and forth. And the electrons can just go back and forth independent of oxygen. And that's why, like, with cyanide, it occupies the oxygen. And so people are starving from oxygen, Right? So when you give methylene blue, they're able to actually make energy without having to utilize oxygen.

Okay, so when, if I take methylene blue and it is getting absorbed into the body, where's it actually going? Like, what's it actually doing? Is it entering into the cell? Is it like, attaching to the membrane of the cell? Is it interacting with the mitochondria inside the ce or do you know what the actual mechanism would be?

Well, so absorption wise, I think this is a good point, is it's extremely absorbable orally, and where you want it to absorb is the stomach. You don't want it to go into the small intestines or the large intestines, because then it can have a negative impact on the microbiome.

But what about when you do the suppository?

Well, so the suppository would probably not be a good idea to do long term. Okay, Right. But if an individual was looking to deal with.

An acute condition, especially something like that, and like introducing light therapy.

And would you not want to do it long term because it might impact the colonic flora in some way?

Exactly.

So it just, like, cleans things out too much.

Right?

Okay. Yeah, got it. All right, so it shouldn't be in the small intestine or the large intestine. It gets absorbed. But you said from the stomach.

Well, you preferably want to have a delivery system where it's, like, so encapsulating it would not be a good idea because those capsules oftentimes don't open up until they get into the small intestine. That's why we created the bar.

Right, okay.

So the bar. And so when you say bar, you're.

Not talking like an energy bar. It's like a little troche, right?

Yeah.

It's easy. It looks like this.

It's a trochee. But not meant to dissolve. Unless you. If you want your mouth blue, you can dissolve it.

Okay.

So you cut it into whatever dosage that you want. You drop it in the back of your throat, and then drink something down.

Okay.

And then it'll just completely dissolve right in the stomach. Now the other option, you don't have to.

You don't have to do the blue mouth thing.

You don't have to do the blue mouth.

Why do people say you gotta let it dissolve in your mouth?

Because they're misguided or they're trying to promote maybe the product that they have that dissolves in the mouth.

Okay.

But like. So a lot of people use drops, and that's another option as well. So between the drops and something like what we have would be the best way to deliver methylene blue.

And when you say the drops, oral drops or eye drops, well, you get.

You can get drops that you have methylene blue, and you can drop it.

Into water or you can just deliver it straight into the mouth. That's like what Bioblue, I think, has drops, but then you've got the eye drops also. And I want to talk about those in a little bit because there's this weird thing going on with the eyes. I think you said the locus coriolius or whatever. And I want to get into that because I'm fascinated by it. So the delivery mechanism, you can swallow and then it gets into the stomach and then what happens after that?

So it gets right into the bloodstream. And methylene blue is a very small molecule. So it has no problem crossing, you know, the blood brain.

It gets absorbed into the blood, crossing.

The cell membrane, crossing the membrane of the mitochondria. It just gets right in.

Okay. And then once it has crossed the cell membrane of the mitochondria, that's where. Back to this thiaz. Thiazine, Thiazine. Thiazine and amide. I think you said amide would take place where the thiazine would allow it to contribute electrons.

I mean, I, m, I, N, E.

I mean, okay, so the thiazine could donate electrons and those could travel through the electron transport chain and allow for more production of ATP. And then if you needed to recycle certain factors and accept electrons, that's where the isine, I mean, would come in. And that's where you could do things like recycle, let's say, like nad, for example, to restore some of the byproducts of cellular metabolism.

So there's four complexes in the mitochondria. And the job of the mitochondria. The mitochondria is really a fascinating structure. It's like a little micro rotor and it goes 9,000 RPMs, these little rotors producing ATP. And so the electrons are moving through this chain. And so the mitochondria's job is to move electrons. And in the process of moving electrons, it's exothermic, so it produces heat. And we take that chemical heat making mechanism and it produces ATP and it moves it through these four complexes. And there's been a lot of molecules that they've looked at that enhance mitochondria, but that nothing that they've seen that works on all four complexes. So the research shows that it enhances mitochondria up to 30%.

And so when you say enhances mitochondria, specifically ATP production or efficiency of ATP production.

Yes, and the efficiency as well. Because when you look at efficiency, you're thinking about in terms of how much oxidation is released from that process, how much pollution. Basically, like an automobile that might not be like an older automobile that's hogging a lot of gas and producing a lot of pollution. Right. Versus a newer car that's more efficient, uses less gasoline, less pollution. And so we want these young, healthy mitochondria because that pollution creates a lot of inflammation in our body. And it's really linked to aging and a lot of diseases.

Okay, okay, got it. So mitochondria, the mitochondria are charged up, so to speak, by this methylene blue. But where does light come in? Like, why are so many people, including you, you gave me an IV and I literally had a methylene blue drip iv. But you had a little light attached to the IV stand. Took a picture of, it's on my Instagram. I could probably put it in the show notes as well. If you guys want to see what it looks like. And the lights irradiating the blue as it goes into my bloodstream. It's the sexiest looking IV ever. But what exactly is the reason that you combine it with the light?

Well, so the last protein complex, which is called cytochrome C, cyto, meaning cell, chrome, meaning light.

The last of the four that you described. Right.

It's designed so that we can take, you know, we've got some beautiful sunlight coming in here to the living room, and we can take those photons, but the photons have an easy time making it into the cells of our body because our skin is designed to block the rays. Right. I mean, most of these photons don't make it past the first millimeter of skin. That's why you start getting into some of these, like, lasers and red light. And like with the sauna space, with the incandescent lights, which I think are more penetrating than most, it can get deeper into the body and those photons get delivered to that cytochrome C. And the photons can be used as energy, just like the electrons. So we can use either a photon or an electron to make energy.

Okay, that actually makes really good sense. So when we were talking about methylene blue donating electrons to the electron transport chain, you're saying that photons from light, particularly from what I understand, the red light spectrum, can contribute photons that would also act in the same way as electrons in the electron transport chain.

Right. So then you have like an enhancement. So it's a synergistic effect that the light has with the methylene blue.

And is the light somehow also interacting with methylene blue to make it more effective?

Well, so methylene blue is blue, right?

Yeah.

And so it's going to reflect blue and absorb red. So that's why it's absorbing exactly the most penetrating type of photons, which is those red and near infrared spectrums. So that's perfect for methylene blue. So you really want to be in somewhere in the neighborhood of 660 nanometers when you're looking at these red light, which most of the.

Red light panels, a lot of these devices, the lasers that we use for inner ear regeneration, and we use some lasers on your knee when we did your procedure. These are all very commonly within that kind of 660.

Yeah, well, you're a man after my own heart with a red light. When I arrived here the other night, just so you guys know, John's whole house is just red, and it's incandescent light, and I got a red light lamp in my room and a little red light therapy device at my bedside and a red heating lamp and the whole place is just red. If you guys have never experienced outfitting your house to be red by night and then sunlit or just naturally lighting like incandescent or halogen by day, it's a game changer for sleep especially. So red light plays well with methylene blue.

Yeah.

Do you know of anything else that you would stack with methylene blue to enhance the effect? For sure.

Silver and gold. That's why we put silver and gold in the blue eyes.

You were about to sing a Christmas song. Silver and gold.

Well, so silver and gold are extremely. What's called photodynamic. Right. So this is a whole conversation about how light can interact with substances in our body to even further enhance this effect through the cytochrome C. And so there's been some studies showing that both silver and gold and methylene blue even further enhance this whole photodynamic. It's called photobiomodulation.

And you're talking about like oral silver and gold, you take it orally?

Well, the protocol we did in the clinic, we did IV silver. And then we have a gold that we'll have people nebulize or we'll put it in their eyes or we'll do intranasal gold. And so that's the delivery we do right before we run the methylene blue and then we do the intravenous red light.

Okay, what about so called other.

Agents that act similarly to methylene blue in terms of their interaction with red? Red light like shilajit or photocyanins like spiraling and chlorella or anything like that.

They're all amazing photodynamic in there. Some of them are better than others. Like I would put methylene blue at the top of the list and then you have things like sterile stillbene and fisetin and quercetin and green tea extract. And riboflavin is amazing, especially if you're looking to have an antimicrobial effect. There's been some really good studies about infusing riboflavin, which an individual at home could take it orally and then go into the sun or go into a sauna. And they were actually showing that it was having a huge impact on Covid, Epstein Barr, hiv.

That's amazing. Even though you're not allowed to say that. I'm joking. I'm looking at the label for this lumital blue. This is a blue bar you were talking about. You actually have that in here. Phycocyanin. I didn't realize this. Egcg, lutein, quercetin, curcumin, riboflavin. And then you got a probiotic blend. So you have a lot of that stuff already in here. How come you don't put silver and gold in here? It's too expensive.

Well, that might be a next generation. So what we have people do is take silver orally so they'll get, like, a silver product and they'll use that at the same time.

Okay, so we're about to go play pickleball in the sunshine after this. So I should put one of these. And how much do you take? I'm just gonna show on the camera how this is done. You, like, slide it out like this boring podcast as you listen to the audio version. And then I would just, like, swallow, like, half of this.

Yeah.

All right.

You want me.

I already took some.

Okay. All right. Tastes pretty good.

My dentist commented the last time I was at the. So you click that. I had a little blue in my mouth.

Your mouth is so blue right now.

I'm chasing it with some water.

It's all right.

It's on brand, bro.

Yeah, normally we put it in the back of the throat and drink down, but, you know, I'm a rookie. It's not really that big of a deal that your mouth is blue because it'll. It'll clear up. It's not gonna stain or anything.

Yeah, yeah. Okay. Speaking of staining, by the way, how do you get rid of stains? Like, if it does get on the floor, toilet, or anything like that? You got any secret methods?

There's a solution that a friend of mine discovered, and I'm actually. I thought there was a bottle laying around. I forgot the brand. But I know we did a podcast the last year at Elements of Vitality, and I think we highlighted it, so you're gonna have to go back and watch that one.

See, I found swishing my mouth with baking soda helps out quite a bit.

Vitamin C is really good for that because, well, there's a form of methylene blue called leucomethylene blue, and that's basically white. So that's the reduced form of methylene blue. And it actually might be. It's actually a good hack to take vitamin C along with methylene blue because that'll even enhance the absorption into the cells.

One thing that I find interesting is that some people don't find that their urine turns blue as much, and it reports back to you.

I've heard that means you're not really using it properly.

No, it means that you've got a lot of vitamin C. Oh. And so it converted into leuko. So if people either have a lot of tissue, vitamin C, or if they're consuming vitamin C, they may not have a lot of blue in the urine.

Does that mean that the vitamin C is impacting the effectiveness of the methylene blue? Like, it's not working as well?

Not at all.

Or it's just turning a different color?

Yeah, it takes the color out of it, but it's not going to minimize the effect. In fact, it enhances it.

I briefly mentioned that you're kind of like into using different orifices for delivery mechanisms beyond just making me emit gas out of my genitals. So the idea behind this, I think you described to me as a protocol was the Garcian Gassian, something like that, that you learned in terms of different ways that you could introduce compounds into the body.

Gassens protocol. Am I remembering that right? Okay, I'm not remembering that. Okay. Well, anyways, I think it's actually in the book somewhere. I wrote down a note that it is ghonish. It's a ghosnish protocol. Anyways, it's this idea of different deli. Yeah, Dr. John Ganesh protocol. And in the book somewhere, yeah, Ganesh protocol. Like, you go in. Oh, Ganesh, Ganesh, Ganesh, Ganesh.

Okay, so sorry, I should have done my homework.

Okay. Take care of your doorways, it says. So get into that for me.

Okay. All right, so Ganesh is the Hindu. They call the Hindu lord of doorways, right?

So in.

In Hindu, they see Ganesh as like the bouncer. So they pray to Ganesh and Ganesh will let you into heaven, right? So a lot of times you'll see T shirts that says, like, remover of obstacles. And so I look at doorways as orifices, right? So we have doorways. Our nasal, our mouth, our ears, our eyes.

Our anus. So when I look at healing, what I discover is that at the core of all diseases is one thing, which is there are stressors that result in inflammation that shut down mitochondrial energy production. And then disease will present itself uniquely with each of us based on our genes, right? So if we can't adapt to a stressor, then the body doesn't have the energy to adapt from the mitochondria. And once, once you hit that. That threshold, then the body goes into a disease state. Like if you had an infection and you're fighting that infection and your immune Cells need mitochondria. They need ATP to do their job, to kill whatever infection it is. But if that inflammation hits a certain, certain level, there's something called the cell danger response.

Yeah, cdr. I've heard of this before.

And so what, in essence, there's another term for that. It's called the Warburg effect. So Otto Warburg was a very famous researcher who discovered that cancer and oxygen can't coexist. And he realized that with cancer is that there's a switch from the energy being made in that electron transport chain, which is what we talked about earlier, out of the mitochondria into the cytosol. And it's called fermentation. And you only get about 10% of the ATP through that process versus the mitochondria. The mitochondria is like, epically effective to make energy. And that switch happens when the cytokines or the inflammation reaches a certain threshold. And so for a lot of people, that might have been, you know, watching the news and hearing about the cytokine storm, where people would die from COVID this is where the infection raised the inflammation and it hit a certain level, and then the individuals shifted to fermentation where they didn't have. It's like, you're like, imagine if you have a battle and you have a hundred warriors out there, and then all of a sudden, 90 of them got, you know, got killed. And you have to fight this battle with 10 people, right? You're gonna lose that war. So it's the same thing with the white blood cells. You're fighting.

This battle, and then you get demolished. And so this is literally happening when it could be the flu. Most older people, you'll get pneumonia, and they'll die from the flu. One of the most common ways that our elderly people pass as they get the pneumonia, right? And so this is happening because as you get older, your mitochondria become weaker and weaker, so you're more susceptible to this switch, this Warburg effect. Also, cancer is more common as people get older because their mitochondria aren't as strong. In fact, mitochondria health is at the core of cancer.

Is this one reason why some people will recommend ozone in conjunction with chemotherapy or even as a standalone treatment for cancer? Because cancer cells can't survive in the presence of oxygen.

So that. And.

If you use ozone, ozone is activating.

PGC1 Alpha. This is a gene pathway that extreme exercise, cold, plunge, fasting, some of these extreme hormetic Activities activate this PGC1 Alpha. And what changes. Yeah.

I talked about it, by the way, in my very first book, Beyond Training. I wrote all about the PGC1 Alpha pathway and how to trigger it through.

It's amazing.

Through a minimum effective dose of training.

Right. So that's a sensor that activates mitochondrial biogenesis. So it activates mitophagy. So your body. So imagine. Think about it like this. We have this signaling and this sensing in our cells where all of a sudden you have all this oxidation. Right. Like in our clinic, we do an infusion of ozone. Right. You can also do rectal. And so all of a sudden, there's all this oxidation because the ozone interacts with, like, tiny little fat particles in your blood. And then you get oxidized lipids that are then signaling inside the blood. And then the sensing is like, wow, where's all this oxidation coming from? And that's saying, well, there must be a bunch of dysfunctional mitochondria. So then it goes in and it says, we need to recycle all these old mitochondria. So it's signaling this mitophagy, which is like cleaning and recycling old mitochondria and the mitochondrial biogenesis, where then you produce all these new mitochondria.

Is that part of why hormetic stressors work is mitophagy? They're actually, like, killing and then recycling new mitochondria?

Partly, yeah, depending on which hormetic stressor. But the ones that we're talking about, like exercise and ozone, is a really epic way to activate this pathway.

Yeah.

And people can actually do fasting. And what I like to do is, is use ozone during their fasting phase if you want to get a deeper.

Because fasting would already activate.

You're already in autophagy, but then you want to really fix that.

I've never thought about pairing fasting with ozone, but the mechanism of action would make sense if you wanted to get accelerated results from the fasting.

Yeah.

Interesting. So back to ozone for a second. I realize this is a little bit of a rabbit hole, but why the heck did you inject my prostate with ozone, you bastard? It did hurt for a couple hours afterwards, I'll admit. I had an ice pack on my. On my lower abdomen, but describe that to people. I'd never heard of doing that before, and you told me it's incredible. But explain to people why.

Well, yeah, I mean, methylene blue is achy when it's injected into the body, so it's kind of. We did put an anesthetic in there, so it was Better than it would normally be. But it aches for a couple of hours, and then it feels amazing. We've used methylene blue injected into some joints, and I've had it injected into a few of my joints, and it hurts, but it's tolerable. And then all of a sudden, it just feels amazing.

So prostate. I'm glad you asked me that, because it's a huge problem, right? I mean, benign prostate cancer.

Fellow. All guys, if they don't die of prostate cancer, die with prostate cancer.

Exactly.

I don't know if that's true, but yeah.

So the problem is the prostate is, like, kind of encapsulated, so.

It'S a breeding ground for infection. And so we accumulate infections and molds.

And fungus and so forth.

And these can also be contracted to a partner, right?

They can. Yeah, through the semen. Okay. That's where we test people. So we have a protocol in our clinic where we're. We're really exciting. What we're doing with prostate is we do a prostate. A semen test. So there's a kit that we can send to their house. They test their semen, and just about everybody has some level of infection in the prostate. Right. And so then we can see what microbes are there and we can match. Sometimes we may take a couple of antibiotics because the report tells us which antibiotics were determined against those microbes. So the cocktail that we'll generally use with this prostate injection is two or three different splashes of antibiotics. Some prp, because that's your natural immune cells, and methylene blue, a certain level of methylene blue. And then afterwards, we chase it with some ozone. And that has just been a game changer for everything from people having to wake up frequently urinating, which is a sign that you have some swelling of the prostate.

I don't know if it's placebo, but the past two nights, I've gotten up to pee. Last night, I didn't. Well, I went to bed early, and I was in bed reading. And it was one of those things where right before I got to bed or went to sleep, I was like, oh, gosh, you get up to pee. But then the night before, I didn't get up to pee during the night. Early in the morning, when I finally woke up, I did, because usually I'll pee, like, sometimes two or three times during the night. So since I've gotten the injection, at least so far, knock on wood, it's at least had that effect. My PSA has always been somewhat low. But what I find most Intriguing about this. My wife's going to kill me for saying this, but I'm going to say it anyways, is when my wife and I began to have more unprotected sex, she started getting more UTIs and yeast issues and fungus. And it's possible that I could have had infections in my prostate that I was contracting to her. Right?

Yeah. Well, that was the conversation that we had that led to, why don't we go ahead and do this? We normally test the semen, which we just didn't have time. So you're there and it's like, let's go ahead and do it.

Yeah, yeah. Interesting. And then you didn't do stem cells in the prostate, but I think you have like a special form of stem cells that you're using now in your clinic. You did them in my. In my knee and I believe also in infusion. You have Excels. I haven't talked about Excels. Not the spreadsheets.

Yeah. So the Excels are a line of stem cells that are extremely exciting. I've been in this field for almost 20 years. I mean, we were one of the first clinics to use bone marrow and we were doing liposuctions and dissolving the fat and ultrasound guidance injected into various joints and so forth. So I've been with a lot of technologies over the years. Right. And so these cells, they're considered adipose derived stem cells. So they come from fat. We're able to get them. So they're frozen and we take them out of the freezer.

From who?

Well, we have a partner that is giving free liposuctions to young, healthy volunteers. You can sell your fat. They take the cells from the fat.

And.

They take it through a process. And they don't accept people that have been vaccinated, highly vetted, and then it's highly purified. So people thinking about, okay, I want to go to Mexico, I want to go to Panama because I want to get these expanded placenta.

Yeah, I hear that all the time. Everybody's like, I'm not going to get my stem cells done in the US because not as good.

Right. And it's like 20, 25 grand.

Right.

So this. So placental stem cells are like, their survivability is ours. That's it. They don't survive long. That's why some of these clinics will do infusions three days in a row because they're trying to get that action. These cells last weeks. And so the way that stem cell therapy works is it used to be that we Thought that a stem cell would migrate to a certain tissue. Right. So damaged tissues that are inf. Inflamed home in and attract the stem cells.

Right.

And so they go to that damaged area and they stick to that area and then they start to excrete exosomes. So a lot of people might be hearing about exosomes, and you can get placental derived exosomes that you can use to inject into various parts of the body and IV. And people are doing IVs.

And so that's like. I would think about exosomes as being the juice where the stem cell's the orange. Right. So it's the stemness from the stem cell. And those exosomes are packets of something called rna, which is just information. So those packets of information are going to go in there and signal the existing cells and tissues to go into a youthful growth repair phase. So ultimately it's your own cells basically regrowing themselves. It's not the stem cell cell differentiating as much. That does happen sometimes. And the X cells are four times more faster at differentiating than placental stem cells. So I find them to be superior. And I've done treatments over the years with just about everything. I've gone to Mexico, I've gone to, you know, I've seen it all, I've done it all. I've never felt as much of a, of a, of an improvement since I did this particular line. Like I was in the gym, like, like.

Do a lot of people know about these yet? Because I had never.

Well, they're gonna know.

Yeah, Right? Yeah. Now. Yeah, yeah, yeah.

So they're, they're not new.

Do you still combine them with exosomes, these X cells?

Sometimes, yeah, some. When you start getting into this, this area of regenerative medicine, you don't want to have someone that's like trying to just shoot everything with the same thing. So there's so many different presentations, there's so many different types of tissues in the body, types of injuries. The tear could be big or small. You have to be able to see these things on ultrasound to know what you're dealing with. And then guide the injection.

Under ultrasound. And so once you can really appreciate what you're trying to treat, then, then you start to match it with the different. Sometimes bone marrow is epic. I mean, we've been using bone marrow for.

Instead of fat.

Fat's good too. Fat is really epic. Right. Except the liposuction can be a little bit of a challenge.

I know, I got it once it Was so hard. Cause I'm so lean.

Especially for us people that stabbing in.

My back for hours.

Yeah, yeah. So like, you know, as Harry Adelson does in his clinic, I remember way back, looking at Harry doing the bone and the adipose. And we had been doing the same. I called it Maripos. And so we were doing the same protocol. We were doing a lipo, and we would inject the fat and the bone marrow. And I mean, we had people with just emaciated knees, bone on bone knees that were back out playing tennis. And I'd see them 10 years later, they would come in and they'd do one knee. They'd be saying, hey, I need to do this other knee. So the durability on the treatment.

Every time I get a treatment on my knee, it gets better and better. Three years ago, I could barely walk. That's how bad it was. And it was constantly swollen. I couldn't play tennis, couldn't play pickleball. Now I would rate it at like, 85 to 90%. After what we did the other day. Kind of like settles in and everything, I'm very curious to see how it continues to progress. But, yes, this works. And I haven't actually had to get surgery. These are minimally invasive procedures. So, you know, I know that there's a lot of little areas that we're diving into right now, but this one, I really want to talk about holding it up. It's called blue eyes. Methylene blue. Silver eye drops. You sent me these a month ago. Yeah, I started using. They're fantastic. I wake up in the morning, I have my big glass of water, and before I go down and flip on the red lights in my office, I've been putting two or three dots of methylene blue into my eyes. And I'd rather you explain why this is. I know it comes back to the protocol that I butchered. Gashen Garshan.

Ganesh.

Ganesh. I was close. And it's not a doctor. It's a Hindu God. Ganesh. But why the eyes with methylene blue? What's going on?

Well, so I had a friend, and she owns some. Layla Sentner. Some people might be flying.

Yeah, I met her the other day. She's fantastic. She was that whole academy, that EMF free school that she's building in Miami. Nuts.

Yeah. So she sent me a picture. She got an eye infection, and there was a strain of COVID that was affecting the eyes. And so I had. It just immediately popped into my mind that we need to make a silver Blue methylene blue with silver eye drop. And then I thought, well, some EDTA would be really good because that will help push it into the, the tissues better. And so we immediately sent that to her and she had a bunch of teachers and students, and so they were like, oh, my gosh, this stuff is just clearing it up. Like the next day, people were much better. So it was originally something that was just for acute infections, which we're seeing some positive results with that.

You mean like if I get the sniffles and feel like I'm starting to come down with something?

No, it would be an infection in the eye.

Infection in the eye. Specific.

So after making that, I started to think, well, why don't we put some gold? And I was able to source a really quality gold, which was very difficult to find. And I started to utilize it when I was sun gazing. And I just started to realize, like, this is really magical because it's photobiomodulation. So I'm at the beach, I'm grounding, I'm watching the sun come up, and I've got the rays of the sun coming up through the silver gold and methylene blue. And I was just noticing I was seeing a lot better and my brain felt like it was turned on.

Yeah. If any of you are listening and you haven't had a chance to do breathwork, Dr. John Style, we did this the other day. You do the methylene blue in the eyes while you're looking at the sun or red light. And then we had a special, like, minty oil stuff that he applied to our perineum to kind of like the root lock in the. Yeah. Called Rootzen. This is another one of his products. He put the root Zen on your perineum with the methylene blue in your eyes. And then you had the breath honey, which is. And I've been actually doing that when I oil pull in the morning, doing a couple drops of breath honey because it seems to really freshen up the mouth pulling, which I actually mouth pull or oil pull with ozone oil from this company called simply O3. But I combine it with your breath honey now and then when you are getting up into a state where you're really ready to pull in all the energy and oxygen. You've got the Zen spray, which is very similar to like Hop Bay, mixed with essential oils. It just blasts you off. And so you've got the perineum, the eyes, the mouth and the nose all locked in with special compounds for breathwork. You just got to come up with something for the Ears now?

Well, you can put the. We're going to be launching Blue Ears.

No kidding?

Yeah.

Blue Ears. Sounds like a food stand at Disney or something.

Well, it'll be a similar drop that you can place into the ears. And we're going to start doing some of our own research on the impact that that might have on hearing loss and tinnitus. And as you know, we already are pioneering a lot of things with the inner ear with our sunove protocol, which is that lunar Lumimed laser treatment that I brought here from Germany. And then we started using stem cell injections into the ear. And so we're using the combination of both of those. And of course, we want these patients to be taking methylene blue while they're.

Going to the table. I talked with a couple people at your clinic the day I was kind of doing a tour of everything, and they said their hearing had actually improved from whatever protocol you were doing for hearing restoration, which is incredible.

So.

And a lot of people don't think that you can do that without an implant, you know, or hearing aid. So the thing with the eyes, though, when you're doing the eye drops, is this related to the part of the brain that you're talking about, like the blue spot in the brain, or is that related to something different?

So, well, the. I'd love to dive into the blue spot. The pineal through the suprachiasmic nucleus is going to have the biggest impact with the blue eyes.

Okay.

So the photons are going to pick up the signature of the substance, and it's going to carry it through information back to the pineal. And I think that's why there's more of a neurological effect that you feel when you do those drops.

So the locus coeruleus is in the brain stem. It's in the pons. So it's a very primitive area of the brain, and it's command central for stress, basically. So this is where it's the norepinephrine release in the brain, which is like that neurotransmitter that excites. Right. And anybody that's had a lot of anxiety, they know sometimes too much norepinephrine is not so good. And this is a real problem today is that a lot of people, they're overstressed. There's too much neuroscience, norepinephrine, the brain is too excited. And this causes a lot of premature neurodegeneration, a lot of different.

Psychiatric disorders and anxiety and phobias. And ultimately, I think our spiritual practice for all of us is the ability to be more deeply relaxed and more present in the moment. And this is going to be directly related to how well we can calm down the blue spot or the locus coeruleus, because otherwise that locus coeruleus is just signaling. Any area in the brain that is going to be producing norepinephrine is going to be triggered by that blue spot. There's a frequency that the blue spot pulses at. The faster it pulses, the more norepinephrine is released, the slower it pulses, the less. Right. So this is where we're, when we meditate and we're really calm, we do breath work, right? After breath work that you just. In that Zen place, you are completely slowing down your blue spot, right? So the blue spot also stores short term memory. It's like a little thumb drive. So as you're going through your day, you have experiences and you have that short term memory of your experiences. And in order to consolidate those memories or integrate, like if you have, let's say you have a session with a psychologist, right? And you take all that new information and you're trying to make sense of it, and you want to take that information and integrate it with all the things that you've experienced before that to integrate it so that you can really learn. Right? And the ability for that memory consolidation to occur is where the short term memory from the locus coeruleus gets put into the higher brain centers. And in order for that to happen, the blue spot literally has to pause to 0.5 or 1. And that happens at night, and it happens during REM sleep.

Okay.

So if an individual's not getting REM sleep and they're not adequately pausing their locus coeruleus, they're going to probably have problems with phobias. PTSD is really commonly related to this because you're perseverating over. Like you could have an experience where something really scares you and then you're just thinking about it over and over again. But if you're able to consolidate that and start to integrate it, you start to make sense of it and it kind of starts to take some of the norepinephrine release, right? Because you think about like, oh, the trauma and you get that hit and then the heart starts to beat.

That cell danger response type of syndrome that you were talking about, very similar to that.

Well, the cell danger response is at a cellular level with an energy production, but it's.

This is more on the nervous system level.

It's related because these are all stressors and all these stressors ultimately are going to shut down your life force, because if you have a lot of norepinephrine, you're going to be producing more inflammation in a lot of indirect ways.

Okay, so the locus coeruleus, how is that impacted by methylene blue? Or is it?

Well, that's what's fascinating. So I first was diving into the locus coeruleus when I wrote my book. It's all in your head on endonasal balloon manipulations. And what I was finding was when you breathe, your respiratory cycles would go and pace other centers in your brain. So if you slow your breath down, it actually starts to entrain the locus coeruleus to start to beat slower. If you start breathing faster, that respiratory rhythm will speed up the pulsing of the locus coeruleus and you start to have more norepinephrine released. So what happens is that a lot of us, our craniums start to collapse. It's a part like. Weston Price did a lot of research on this, and he was able to see that primitive people had wider skulls. They had much wider opened nasal passage. And those sensors are really high up in the nasal passage. And so a lot of times people, because their cranium and their nasal passage is smaller, you're not getting.

That signaling of that respiratory. And so a lot of people could be suffering from anxiety and different types of conditions where there's overexcitability of the brain because the air's not getting up high enough. And so what we do in my clinic is we take a balloon. You've experienced this?

Yeah, it's fantastic.

And we do this expansion technique called functional cranial release.

Yeah, but what's the methylene blue do to the locus release? Or does it.

So I was looking at this when I was writing the book, and then I found this research on methylene blue where they were treating phobia patients and they would expose them to something that they're afraid of. Like, if you're afraid of spiders, they do exposure therapy. And they found that they would give people one dose of methylene blue after the therapy session, and it was enhancing memory consolidation. So these people then could integrate that experience. Experience. And the results were exponentially better.

No kidding.

So, like, anybody doing, like, is that.

Because you think it's actually slowing down that pulse rate of the locus coeruleus?

Okay, so this is where it really gets fascinating. So the locus coeruleus has very fragile mitochondria. The mitochondria are a little bit different. Than most areas of the brain. And.

One of the primary, and this might be rabbit holing a little bit, but.

The primary stressor that really affects the mitochondria and the locus coeruleus is endotoxins, lipopolysaccharides, which come from infections generally.

Right, Infections, or even eating foods that are a combination, from what I understand.

Of sugars and like a gut dysbiosis.

Yeah. A lot of processed foods, packaged foods, added sugars, combinations of sugars and fats that you would find in a lot of modern processed products, and I believe seed oils as well, contribute to lipopolysaccharides.

Yeah, I mean, I think it's the primary cause of disease in the body because it's the most inflammatory substance. And once that inflammation shuts down, the life force disease expresses itself, like we talked about, in a unique way, depending on our genes. So what happens with the lipopolysaccharides, with the mitochondria in the locus coeruleus is they produce this NOX2, which is like a really. It's a chemical that really shuts down the mitochondria. And so because those mitochondria are fragile and the locus coeruleus, so it literally has. It's so chocked full of mitochondria, it's like too many million mitochondria. Kind of like the substantia nigra is really, really high, which is with Parkinson's disease. That's the area that goes south.

Okay.

So we're talking about cells that are incredibly metabolic, demanding, like a bunch of mitochondria, because they need so much energy. And so when our mitochondria start to go south and they're not as effective like we talked about earlier, then the locus coeruleus starts to have some problems. So methylene blue goes in there and enhances mitochondria, and therefore you have an enhancement with the blue spot in the locus coeruleus.

Interesting. And does it not necessarily relate to locus coeruleus, but just in general? Do you think methylene blue impacts sleep? Because I've seen some information that it doesn't. I feel like it energizes me and keeps me up a little bit. Maybe I just have low tolerance. I don't know.

What, do you take it at night? Yeah, yeah.

I recently actually. Yeah, this was a few nights ago at your place. I took one of your melatonin products, but it had some methylene blue in it. I don't feel like I slept as well than when I take melatonin without methylene blue. So is methylene blue something that's contraindicated for everybody for sleep, or is it just certain people who are sensitive to it?

Well, I've worked with a lot of patients and such with methylene blue, and I have not seen many people at all have a problem with losing sleep with methylene blue. I think that when I have, it's usually somebody when they first start taking it. And so then all of a sudden you get this boost of energy at the inappropriate time. So taking it in the morning would be best when you first start. And then it's likely that once you get used to to it, you're not going to have a problem at night.

Okay.

But you have to feel it out for yourself. Everybody's going to be a little bit different.

And walk me through just because I'm curious how this works for you. You're such a wealth of information. Methylene blue, let's say somebody wanted to start using it. What would be like a great protocol that might even include different delivery mechanisms like the blue eyes or the bar or something like that. Let's say I wake up, I'm like, okay, I want to start trying out this methylene blue stuff. What's a good way to start?

Well, so we talked about the delivery. You know, you're going to want to do it orally where, you know, you're. You're going to get the release in.

The stomach first thing as soon as you wake up or you wait a.

Little while before lunch.

Okay.

Yeah.

But if you were going to do red light or light therapy in the morning, which a lot of people do within an hour of waking, you would ideally do it pretty soon after waking up.

Well, that's why I like to take it before I go to bed.

Oh, I see.

I wake up, I go in the hyperbaric chamber. And there's a real synergy with. You had asked earlier about things that are synergistic. Methylene blue and hyperbaric oxygen are epic.

Yeah.

The combination of a red light panel or a sauna hyperbaric oxygen with methylene blue is just.

I think that'd be like a protocol. If you had access to an infrared sauna and a hyperbaric chambers, you'd take methylene blue and then you do the sauna, I would imagine first, because that'll basal dilate things a little bit and then maybe rinse off real quick before you get into your hyperbaric. And then do a hyperbaric session.

Exactly. We call it the mito. Red, blue, O2. And we're literally going to launch a whole section at Mitozen Club.

I don't think I've actually ever tried things intentionally in that order, but I might need to give this a go now. Yeah, that's interesting because I noticed you have your sauna right up next to your barric chamber.

Yeah.

And the refrigerator full of methylene blue.

So it's Jason Sonners. You know, he's like an expert with Hyperbaric. And then Brian Richards with Saunaspace. We're collaborating and we're going to be putting out a lot of content, helping people to kind of create some of these biohacking, if you will, or healing situations at their home. Because this, I think this is empowering people to elevate their health to a level that I don't know any other protocol call that would be as powerful as this.

Yeah, well, it's pretty incredible. Do you ever get tired of me calling you the doctor Strange of medicine?

No, of course not.

Well, I have to admit, even though I didn't really mention it at the beginning of the show, the name of John's clinic is Advanced Rejuvenation in Sarasota. I think it's well worth a visit. John and I are getting into this habit of throwing an event there now. What was this? The second annual Elements of Vitality. Elements of Vitality event where you get to come and guinea pig and try out all the protocols and even arrive early or stay later and do some of the stuff John does with his patients. But I would recommend that if you want kind of like the trifecta of mind blowing information from John in addition to this episode, listen to the other ones I did with him, which I'll link to in the shownotes if you go to BenGreenfieldLife.com MagicBullet and if you want to try, I'm going to be a little commercial here for you, John. So my apologies in advance. I would say that of John's products, the ones that I tend to use the most is the melatonin suppository. If you don't like suppositories, the melatonin oral product called Sandman at night, if I have any day where I want the equivalent of an NAD IV without getting an iv, I do the NAD suppository in the morning. And some people can't hold a suppository in all day. But you just told me most of it gets absorbed in like a couple of hours. So if I Put it in when I get up at 5am and I'm not using the bathroom till like 7:30 or 8. I'm still getting a bunch of NAD in my system. So like the Sandman, the NAD for breath work. I really dig the Zen spray, but I'm going to start trying the breath honey and the root honey and the root Zen now because I didn't really understand how to use those. And I'm doing the session with you, plus the methylene blue in the eyes. And then the last one that I would say I probably use the most is just like the little bar that I just took because it has all the other stuff you talked about in it, the probiotics and the lutein and what's it called? The riboflavin, the egcg. So yeah, it's pretty incredible. So if you guys want to, I'll put a link to John's store and you can go shop around and check stuff out and. Go ahead, John.

Well, one thing that I'd like to just say is we did this epic breath work on Siesta beach the other day and we recorded it.

That's right.

And we're going to put that at Mitozen Club.

At Mitozen Club.

And so you're going to have a link to that. And so it's a $10 lifetime membership fee to enter that. And we have the full line of products that are available to club members.

So certain people can't buy some of these products, but if you're part of the club, you can.

You have. Yeah, you have to become kind of cheap.

$10 a year.

Yeah, I know.

Right?

Yeah. So. So we have. I do. I have done breath work sessions with a number of really cool people and we post them and so it's free to members. So if you're wanting to like kind of delve into using these products and how I use them during breath work, join, you know.

Who else did you do sessions with?

I got Gary Breca. I got Garrett McNamara in there. C.J. macias.

Yeah, there's. There's cool people.

Awesome. Well, John, incredible amount of information as usual. You always take me down these rabbit holes that I don't expect, but I learn stuff from you every week. So thanks for being you. Thanks for being weird and keep up the great work, man.

Yeah.

And for everybody listening in, go to BenGreenfieldLife.com Magic Bullet. And what do you think, man? Go play some pickle ball with some methylene glue in our systems.

Let's do it.

All right. Let's do it.

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