Controlling Genetic Destiny with Synthetic Biology, Part 1 – Andrew Hessel : 913

You're listening to the Human Upgrade with Dave Asprey, formerly Bulletproof Radio. You're listening to the Human Upgrade with Dave Asprey. This is going to be a really fun show to record and just a fun interview because I am a futurist. A big part of what I do. The very, very early E commerce and cloud computing and so creating any biohacking thing, I kind of see a direction, I go there. So I self identify as a futurist. I don't know what pronoun that makes me. It's a. Then is my pronoun. But what we're going to talk about today is the future of biotech and what that means and synthetic biology. And this is a double episode where the first part of the episode we're going to talk about the science of it, and the second part of it we're going to talk more about other aspects of it, about what does the future look like. But, but first let's roll up our sleeves and figure out what is synthetic biology, what does it mean to us. And later, with a different expert, co author of the same book, we're going to be able to go really, really deep on what's the world going to look like in five years, in 10 years, in 20 years. And these interviews are based on the Genesis Machine, which is a book about what's going on with synthetic biology.

And.

And our first guest here is Andrew Hessel. Andrew, welcome to the show.

Thanks, Dave. It's great to be here.

I promised listeners that I would tell them what they're going to get from listening to a show so they can decide whether they want to invest an hour or so of their life in listening to you and listening to me and learning from us and what my promise is, and I'm sharing this with you so that you know and we can deliver on that promise, is that we're going to teach them about synthetic biology and about how we can use computers to gain access to cells of something and maybe write better biological code. And that by the end of this episode, people will understand enough to at least think about the implications in their life and maybe even to think about what they want to do next with their life. Things like infertility, diabetes, depression. And to think about that hard question of if you actually could upgrade the wiring in your body, the code in your cells, would you and should you sound like something we can cover in an hour?

I think we can cover some of that, yeah.

Some of it, yeah. I mean, you'd write a whole book on it. That takes more than an hour.

It was written in two hours. Yeah, right, right.

You must have used some AI for that because one of the great joys of being me is that I get to talk with you after you've spent your career doing synthetic biology and then you spent thousands of hours writing a book about it and you've distilled all that wisdom and now we're going to get like three drops of the most pure essence of all of that work. So it's highly effective. Let's get going though. Okay. You work on genomics, bioinformatics and synthetic biology. Most people don't know what any of those are.

I can walk you into how I got started because it's really not that complicated because I started in the early days when things were pretty straightforward. I think they're getting a lot more complicated fast, and that's part of the story. I started in the early days when things were pretty straightforward. I think they're getting a lot more complicated fast, and that's part of the story. But my. When I was younger, I took a look, you know, at the world and thought, what am I going to do in this world? And I realized I'm. I'm a minimalist by nature and stuff doesn't matter to me. So I wasn't really interested in most of the things that, that other people were interested in. It narrowed down to. I was just interested in life, like all life. And I knew enough biology that all life is based on cells. So I thought, well, I, I have to go and learn about these cells. So I went to school and started learning cellular, molecular and microbial biology. It's like starting at the ground floor in life and saying, how does all this work? You know, my colleagues that were more interested in, at the other end of the spectrum, humans, which are trillions of cells, all organized into the most complex biology we know about. They went into medicine. I stayed working down in the trenches with cells and molecules and what I. And at the time, it was still pretty early. What was starting to happen was we were actually know people have always dissected animals. You know, you may have done a frog in high school. We start to do molecular dissections, which was really interesting, really getting down into the guts of these systems. And. And we started to do the first sequencing, which is again, one of the molecules in the cell that everyone knows about. It's the most well known molecule is the DNA molecule. And, and that's like, it's like magnetic tape in the sense that it's the Molecule that stores the program that runs this biological machine called the cell. And we started to digitize it with sequencing technology. Literally a machine that takes that molecule and starts to read the information that's encoded on it. And that information is digital in the sense that there's four chemical bits of information that can be ordered to produce the program ATGC instead of 0 and 1. But a lot apart from that, it's a lot like computers. And. And I just started watching the world of computers and the world of biology start to intersect. And this was decades ago, and I realized, wow, the more I was starting to use my computer more than any other biologist, just processing this information. That's where the bioinformatics comes from. I was building databases and dropping information in, and I realized, wow, everything I'm learning about computers and networks seems to have a biological analog. So my brain just kind of naturally loved this, and it totally does. Yeah. And so I just kept getting more and more interested in this and what I started to realize. Well, all life has basically the same machinery in the cell. Doesn't matter whether it's a single celled organism like a bacterium, or you and me. The core machinery is the same, the programming language of DNA is the same. And all the diversity we get in the natural world around us is really just different software. And I was hooked. After that, all I wanted to focus on was genomics. And so being genomics, being reading the DNA code, getting it into a computer, software programs for analyzing that DNA code because it just looks like a string of letters, you know, how do you put meaning into that? And then, and then synthetic biology is where it gets interesting because now you actually start to want to program that code. You actually want to start writing programs. And that sounds a little weird, but once you've sequenced an organism and got that information into the computer, it's like using a word processor. You can start to cut and paste and delete and duplicate, no problem in the computer. The fun part with synthetic biology is once you've finished any manipulations and analysis, we start to get a machine that printed out DNA. And once you decide, I want to write a program, whatever that program may be, I'm going to hit the print button and go and write that biological program and try and load it into a biological system. So that, in a nutshell, is what synthetic biology is. It's a suite of tools and protocols that now allow us to read genetic programs, analyze genetic programs, and now start to write genetic programs to do something use useful, hopefully.

Well, last time you Were on the show, it was about 2018, maybe around episode 500. We talked about hacking cancer viruses and using a virus as a vector to rewrite your genome. And a lot of people listening are like, but we have to do things naturally. And like guys, viruses have been rewriting our genome naturally for the entire history of multi celled life like that. That's kind of how it works. We're just saying maybe we could do it purposefully instead of accidentally.

Yeah.

Is that an accurate statement?

Well, you know, again we started writing programs and you know, the early days of writing programs were more like cooking. You know, you've, you've heard of recombinant DNA technology. Remember that that DNA molecule is like magnetic tape or film. And so we used to have to splice it. We used to literally have to cut the DNA molecule and put it together to, to get a new combination of letters. And that's how we wrote programs. Back then it was really slow, but we did some useful things like make a few drugs. All of that has been moved just like film and music into digital world. So now we can do this digital editing really fast. But we have a problem once even now we can manipulate that, but now we have to print out that DNA. We have to synthesize that DNA. That's the core of synthetic biology. And it turns out our synthesizers aren't very good yet. Like when I, 20 years ago, we could only write a few hundred nucleotides of DNA bases of DNA. Think of it as the letters that was and we had to string it together to make a longer program. The very first genome that we ever wrote using this technology was, and I mean by we science was a virus. In 2002 it was about 7,500 letters of DNA.

And that's, that's only 20 years ago. And you say only 20 years. That's a tiny drop in the bucket of the amount of time we've been on the planet.

So.

But it's changed a lot since.

Well and you know, the trend lines have changed. But that was the very first genome we ever wrote and it was for a virus called polio virus. But viruses have very small programs because they're not living organisms in and of themselves. They need a cell to be their computer. They're more like a USB stick. They load a program into, into that cellular computer and that cell has to run that program if it's a virus. Usually the program is make more viruses. But, but yeah, so I started, I fell in love with that particular paper where that scientists had Made that program and I realized people are going to start working from the bottom up. Anything less than a genome is just a cellular component like a protein. And that has a ton of value. Some proteins are medicine, some proteins are structural, some proteins are catalytic. They're enzymes that'll that, that actually do a biochemical activity. But I was interested in writing genomes, so I just realized people are going to start to do this. Well, that was 2002. The first genome I ever wrote from scratch and booted up was 2014. So it took 12.

When you say you booted it up, you wrote it. You created the virus via synthetic tech and inserted it into a cell.

Well, here's the cool thing. It's the cell that makes the virus. All I have to do is write the string of DNA that encodes a virus. And that of course is already packaged up inside the virus.

So what do you write the string on? So you write the string of DNA. You're creating the DNA with some sort of 3D printer.

There is basically a 3D printer for DNA. We call it a synthesizer. And we don't have desktop synthesizers yet. There are companies that specialize in doing this type of synthesis and assembly work. Actually there is a pretty good desktop synthesizer yet, but they don't synthesize the DNA in that machine. It's more of a desktop assembler of DNA. But, but yeah, that's exactly what it is. You, you take the program for a virus that you're working on literally on a computer, and when you think, okay, I've, I've, I've adjusted it just right. You hit, you hit a button that is essentially like print. And a molecule of DNA is synthesized. So now you have a molecule of DNA. What does it look like? It doesn't look like anything. It's a, it's a little pellet in a tube. When you get it, it's literally freeze dried DNA. And you, you add a little bit of liquid to it, a little bit of water, and you take that now with the DNA in solution and you have to get it into a cell. The cell is like the actual printer. So it's a factory. So if you get that DNA into the cell and there's, there's some tricks to do that, it's not hard. Then all of a sudden that cell goes, oh, I have a viral genome inside of me. It's like adding an app to a phone. And it starts going, and it just starts manufacturing virus. So the cell does all the work. The hard part is actually writing for us is Just writing the program. So I wrote my very first virus program in 2014 when I was working at Autodesk and that was great, but it was just a virus that infected bacteria. It didn't have any real utility. It's well studied, it's how biologists learn about the mechanisms, but it didn't have a utility. So then I started to go, well what, what do I want to write a virus for? And there's an entire field of virology called oncolytics, which just means cancer breaking. And these folks were making viruses or tuning viruses to, to recognize and kill cancer cells. And I thought that's it, that's where I'm going to direct my energy. So I was very fortunate. I ended up starting a company in 2018 to focus on building cancer fighting viruses. And it's still going strong in New York today. I'm just an advisor. I'm off to do other things. But there's a great team of people for that.

So there's a crowd of people who say you should get all of your nutrition from Mother Nature and we should all live in caves. And I actually don't support that because if you're going to get all of your nutrition from Mother Nature, you should get all of your toxins from Mother Nature. And you should probably only be exposed to viruses from within 100 miles of where you're born and bacteria as well. But that's not actually how the world we live in works. So biohacking literally is changing the environment around you and inside of you. So you have control of your own biology. Now, synthetic biology is the next level of control over your own biology. Just straight up. Right. I've said for years, if I could rewrite my mitochondrial DNA to do what I wanted it to do, I would absolutely do that. And there's probably some HLA Dr. Sequences in the rest of my biology I would love to modify so that I could look at toxic mold and just laugh in its face instead of collapsing in its face as my biology is want to do. How soon will I be able to do those things? And can I be the first?

Well, let's just say we already have the technology to write a mitochondrial genome because it's pretty small. Actually. Let's just say we already have the technology to write a mitochondrial genome because it's pretty small. Actually.

Yes. They think they run us. Well, I'll see you, Mr. Mitochondria. There we go.

So it's always a tricky question predicting the future as you know, especially with these exponential technologies. Which have these dramatic S curves. They're doubling at the beginning, but it's going from two to four is not all that exciting. Eight, six. It's when it's really got. You hit the knee of the curve and it really starts to take off. We haven't hit the knee of the curve yet. We are absolutely in an exponential phase. And if you're tuned to what's happening in synthetic biology, it's magic. Like, you just go, oh my God. The breakthroughs are coming at this incredible pace, but we haven't even gotten started yet because to kind of give you a sense of where we're going, you have to look outside at nature and the incredible diversity of all the creatures out there. Whether you're into play plants, whether you're into insects, whether you're into, you know, pets, livestock, it doesn't matter. All of that, all of that diversity is built on one chassis, the cell, with one core set of operating systems inside that cell, all created using one programming language that we are reverse engineering faster and faster as a species, where humans are hacking all living things and understanding how all that works. So we are going to have, in the move, when we hit that knee of the curve, we are going to start a Cambrian explosion of engineered organisms. And now that could be a small tweak adjustment, or it can be a complete rewrite of an organism, or it can be the creation of an organism that nature could never put together because nature has firewalls. You know, we once you once, especially with multicellular organisms, you go off on the tree of life over here. You cannot reconnect with an organism over here and make a new connection. That's. We have, we have firewalls in our genomes. But going back to biohacking yourself, you can. The hard part of genetically biohacking yourself is that you've got, you're essentially 50 trillion little computers all working together. Each of those cells have their own program. So how do you load a program into 50 trillion computers at once? We don't. It's not.

Or how do you load it into some without it crashing the whole system?

Right. And making.

It doesn't have to be simultaneous, by the way. Managing the Internet is exactly what you're talking about. That was my whole career was, how do you manage 50 million computers all from one consol without, you know, state management being an issue? It's the same in biology.

Right.

There's quorum sensing for mitochondria. If half of them aren't the same as the other half, how does Quorum sensing work. So are we, are we gonna be able to do this?

Yeah. So, so the easy way to reprogram a 50 trillion cell organism is to load the program when we're just one cell. So, so, so I'm so, you know, I'm talking here, the fertility CL clinics and ivf. Now I have two IVF babies. I, I, the, we cover a little bit of this in the book. I was not going to have kids. I had my taps turned off when I was 24 and in Canada, that's, that was tricky. I had to talk to a lot of doctors, but like, I never expected to have kids. And then, you know, life changes. I meet an incredible woman. I suddenly I, she hacked my biology. I wanted to have kids with her. So I end up in the IVF clinic because my taps have been turned off for so long. Let's just say my little swimmers weren't swimming so great. But the, it's a candy store for me. Like, this is some of the most incredible cell biology we do on the planet where we can literally harvest eggs and, and, and essentially fertilize them to make a single cell that now becomes a human being. I was a kid in the candy store. Now if I wanted to change a program, that's the point where you do it and you don't have to rewrite the whole human genome to do that.

It's, I'm, I'm laughing right now because even though I'm an anti aging guy, my first book was on fertility and preconception. It just disconnected. That is the easiest time to get stuff right. But okay, everyone listening to this is already kind of past being a single cell. Right? So if you're looking to have kids, you can do things to reduce their chances of diseases. It's still not legal to do that in much of the world. It hasn't stopped people from doing it. And it'll almost certainly have negative consequences we didn't think of and positive ones we didn't think of because that's how evolution works. So what do we do? Okay, I'm a walking bag of meat with too many cells right now. How do I upgrade them?

Well, that's tricky right now because again, it's the problem of loading the programs into the right thing. Now you can reprogram some of yourselves now and people are starting. There's different ways to do this, but let's just say we're the, these technologies are still in development. Everyone parses it through humans, but you kind of, you have to have, you have to start working in animal systems before you go to humans. It's just kind of the ethical thing unless you're a biohacker. And by the way, there was a, there was a whole chapter in the book that we didn't put in, but I, I'm happy to talk to you about it. It's, it's the rise of the biohackers because oh, how could you not put that in there?

Like I, I made us rise for a reason.

I, I, it's, it, I think it, I don't know. I'll have to talk with Amy actually.

Talking about the other. There's two kinds of biohackers. There's the like the bio curious people, you know, hacking your hat, hacking your cat to glow in the dark. And that actually started in 1993. The use of the word for hacking other biology. And then I used it for hacking our own biology. So you were probably talking about the former definition.

Right. Well put this way I look at. Some of the biggest medical advances have been done by self experimentation.

Yeah.

And we're all, I think you agree with this. We're all experimenting on ourselves in our lives. We have a lifelong experiment in trying to achieve whatever it is we want to achieve. Some people climb Maslow's pyramid to the top of self actualization. Others are just happy just at a certain level, friends and family. But we're all hacking our lives to optimize whatever it is we're trying to do do. Or we're giving up and just sliding to the bottom and hopefully someone will feed us.

Yeah.

But the I, I, the, the, the biggest challenge in doing, in doing medical research or biological research on humans is, is informed consent. And it's really hard to inform people when things are getting more and more complicated and often guided by AI.

It's easy. You just mandate it and then it's not a problem. Don't even know. True.

That's a whole different, whole different.

You aren't supposed to laugh. Come on man.

But, but you know, okay, but it's self experimentation. You have to be able to have some freedom to play with things. But, but you don't want to be the earliest adopter of these brand new technologies. So biohacking and freedom to operate is really important, particularly as these technologies become more accessible and you want to try doing search and occasionally you see the biohackers inject something into their eye or into their skin and you get a program into cells, even if it's in your arm. Theoretically you've loaded that program now, some of the cells in your arm can behave differently, produce a drug, for example.

And it looks like from what we've learned is that when you inject. And one of the synthetic bio technologies that I'm really excited about is MRNA vaccines for anti aging and living a long time. The fact that we used one now for a certain medical condition, we'll see what the results of that are. But it's one experiment of a technology platform. But what they found is they injected into the arm. But it looks like those. It doesn't stay in the arm and it looks like most injections kind of move around so keeping it local. Like lots of studies that showed, oh, other cells in the body were making the protein that the MRNA was supposed to make. But what's an example of completely not, you know, turning on the immune system? What could you do with MRNA as a synthetic biologist saying, oh, I can do an MRNA vaccine, what could you do?

So I want to be really clear. I think the MRNA vaccines, the fact that we took MRNA and got it into the world into literally a billion injections, I think that's such a game changer for this technology. So for people that don't know MRNA is essentially the working instructions to produce a protein. That's. That's all it is. That's all it is.

It's not evil.

So it's a shovel. It is.

You can take a hole with that or whack someone with it. Right.

And it's easy to program like, so it opens the door to programmable medicines and programmable vaccines. So it is really the. I don't hate using this word because it. But. But it's the killer app of synthetic biology. It's what pushed synthetic biology into humanity's, into humanity at a broad scale. No other, no other synthetic biology product to date has, has had such. Has been such so far reaching. Food is catching up, by the way. So. So food is kind of the first medicine. But. But MRNA is so powerful. But the MRNA vaccines that they used were kind of stupid. Number one, it's the first time we've written these programs, so. So I want to be clear. And the first time you do anything, it might work.

They deployed beta code on a large number of compute modes.

Well, it's the first time we've done it. I'm just saying there's room for improvement. It works. There is, but there's room for improvement. The second thing is it was just wrapped in what they call a lipid layer. So it's a lipid nanoparticle that protects that rna. Because RNA tends to degrade very quickly, just keeping it stable was a biochemical feat. But putting it in a lipid nanoparticle essentially is very non specific. When you inject it, it will fuse to different cells. It has no targeting ability. It will fuse to cells, it will drop the program in and it'll run the program in which case, in this case make the spike proteins for coronavirus which stimulates an immune response. So a great application. Whether you, whether you support vaccines or not, this is probably the technology that will be used for all vaccines in the future.

It's one of those things whether you support breathing or not. I really don't support breathing carbon monoxide, but I support other types of breathing. So I don't think at this point unless you know exactly what you're talking about. I also don't support eating protein if it happens to be a protein that will kill you and I support eating protein if it's one that's good for you. So you clearly know this. But just for listeners, if you say you're anti vaxx, you're dumb. Right? Because there might be one that's good for you. There might be 10. Right. And if you say, you know, you're pro vax always, I promise you there's some vaccine out there that some crazy scientist is probably thinking of that might not be good for you. So like that's why we have informed consent. It's not a big deal. But for all of the synthetic bio, our informed consent frameworks and our regulatory frameworks are kind of broken and I think Amy's going to talk more about that. Right.

And I'll leave. She speaks eloquently about it and yeah, I think look, the world is, needs an upgrade in, in a lot of the regulatory structures and that's because things are happening faster, they're more powerful. The individuals and small groups can today can do what used to take nation states. So the rules have to change. Yeah, and, and biotech is probably the most accessible technology and one of the most powerful. Like it's, it's often compared to nuclear in its, in its potential for causing good and bad. But let's face it, if, if you know the kid down the street working in their backyard could produce a nuclear weapon, we would have a problem. Kind of the challenge that we have with biology is the kid down the street using some of these tools could potentially build not an atomic weapon, but an atomic scale weapon.

Well they could build smallpox pretty easily. Basically even get funding from people who are looking to learn more about it or something that's.

Let's just say they probably, he would, probably, he or she would probably have difficulty making smallpox because there's so many red flags around that sequence. No one will synthesize in terms.

Maybe it's built into the 3D printers to stop it. Like you can't make a photocopy of a $20bill. It comes out with little stripes on it for a reason. I hope, I hope there are. Well, this would be cool.

So there is no universal digital layer of protection. And this is with synthetic biology today. There is a, there is an industry organization that self published polices that the, the groups that do the synthesis. Look the, the. One of the big protection areas is when you may have a design on your computer, but until you hit print, it just stays on your computer. It's not going to hurt anything. You hit print now, it becomes a biological program that could be a problem. So there's a, the industry is focused on, on that compilation layer, essentially that translation layer. And that's, that's good enough for today, but it's not going to be good enough for tomorrow. Because the synthesizers that I talked about which limit the complexity of the program you can write today. Those synthesizers are services. But when they become desktop devices capable of printing out viral genomes and bacterial genomes or yeast genomes or human genomes, because eventually writing a gigabase billion based genome like a plant or an animal is going to be within reach of a desktop device like we know that the trend line is clear because every, the, the cells in your body are able to, every time they divide, write a human genome. And that's in a few hundred microns. So there will be biochips in the future that do things today that require large automated laboratories like right DNA.

One of the things that I believe, and I haven't really talked about this, but you're probably the right guy to talk about it with. I think humans are a failed species. We need some core hardware rewriting in order to continue growing and flourishing because we have core behavioral things that allow us, once there's enough of us to just do a lot of really dumb shit as a collective organism. And it's relatively simple prioritization of simple things and probably mitochondria. But maybe we'll do it, maybe we won't. But I think I should be able to upgrade myself even if other people don't. But I don't think I should be able to make other people upgrade themselves. Themselves. So let's assume that I'm a script kitty and I'm going to go out there and write my own code and do all this stuff. And let's say I succeed radically. Is there a way to share how do people know that their stuff worked? If you did something crazy in your lab and like, oh my God, this could change the world, how do you get it out there?

Well, it. So let's unpack this a little bit. I actually think that we're moving in that direction. So the closest technology we have to synthetic biology is the is the technology it stands on, which is digital computing.

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The closest technology we have to synthetic biology is the technology it stands on, which is digital computing. And today you can create all sorts of digital material and send it around the world instantly. You can keep it private, you can share it with a small group of friends, or you can publish it openly. And today with blockchain type technologies, you can publish it and it can never be deleted.

Oh, well, we can't have censorship proof things for synthetic biology could. Oh wait, actually we could. That's why the blockchain, apart from crypto, is, is. Is amazing for this. So you could share it and the world would know.

So you could send. You could send a biological program anywhere using Digital technologies. And if you had a printer on the other side, it's just, it's just like downloading a file, you know, to print out on your printer. So. Or. And of course, people are doing this with 3D printers as well. There's a, there's a site called Thingiverse that Makerbot made ages ago where you could just drag and drop 3D objects to print. So I see the. I'm getting a little bit of feedback, but Dave, I'm not sure why.

Oh, but sorry, let me turn that down.

But we're starting to see that same architecture come into place with synbio. It's still early and so I don't want to get people over excited about this, but any program that someone makes genetically and let's say, let's just, for example, use a really, really simple program. They write an MRNA program and package it in a lipid particle and they put it on their skin and it just makes it glow. It's like a temporary tattoo in the skin. It just glows. And it'll glow for as long as the cell expresses a fluorescent protein, the MRNA will degrade and it'll go away. It's absolutely temporary. Doesn't seem to cause an immune reaction. Right, Cool.

I want that.

Yeah, it's glorious. Kind of the kind of the hello world in biology is making a cell glow.

Wow, there's a great reference. So if you're a computer science person, the first program you probably wrote said hello world and printed it over and over. So, okay, so glow in the dark. I got to make myself glow in the dark is what you're saying.

Well, and yeah, just any. And you don't have to go and rewrite every cell in your genome. You just basically have to make a glow in the dark skin lotion. And wherever you put it on, it's. It's a neat idea.

Anyway, I'm up for it. Totally. In fact, my kids would love it. They'd make themselves glow quite a bit, probably.

So let's, let's just say some biohacker writes that program, does it, puts out a YouTube video and basically says, here's the program, you know, here's what I made. Feel free to go and duplicate it. That's out in the world. Now that's a very simple example. Kind of harmless and could very well happen with this today's technology and the number of people getting access to that technology. But let's take it one step further. Let's say you've just been diagnosed with an untreatable brain Cancer. And you have access to these tools and technologies as well. And the doctors already, they've done a biopsy and you've literally got the genetic information now available for that brain cancer. There is the possibility you could design a brain specific virus. There's a number of viruses that get into the human brain. And you write a program from the literature to kill those cancer cells. And you're never going to use it on anyone else. You just want to try and save your own life because you know that.

It'S untreatable, that you have a fundamental right to do that. Anyone who tries to stop you from exercising that right is a murderer. And you have a right to self defense against someone like that.

And this is where we kind of have to think about all this stuff differently because, well, maybe you don't have all the tools to do it to yourself. Maybe you actually, maybe you're the person with cancer, but your son or daughter is the one that is taking the synthetic biology training and they decide that they're going to go and, and help you. Now that's, we're on the cusp of that because there are so many smart people going into this field. It's really, it's really, you know, we, we spent the last few decades programming computers. Now the, the kids that are really looking to the future are thinking, I'm not going to program computers. That's, that's relatively easy. I did that in grade school. I want to go and program life and I want to write programs that are going to be valuable which may be the, you know, to fight a cancer. It may be to cure a disease like diabetes because that's, that's just missing a protein, you know, insulin. It might be to, it might be because you're, you just, you want, you want to make a new food that doesn't involve animal suffering. You just want to grow large amounts of chicken like protein or beef like protein like whatever it is. People are going to start using this technology more and more for things that they think are important. And as the cost drops, it gets faster, better, cheaper and more powerful. Because now there's a growing community of programmers and tools. We're going to see the creativity get ratcheted up to 100. This is what I think is so fascinating.

If I wanted to go on the offensive and use synthetic biology to control the brains of politicians, whatever brains they have, what would I do? Because that's what they would be trying to do to me. So this is what hackers do. We look at what they're going to do. And then we figure out countermeasures to protect ourselves. How does that work?

So programming brains. Brains are the most complex meat in the known universe, right?

They are.

So it's not easy to program a brain. We tend to use. Try to. And tool to tools like education and advertising.

Propaganda.

Propaganda and other manipulation that, that's, you know, what you hear and see and, and how you process it, which can be guided by education and propaganda, et cetera, is how we program brains today. Now is it possible to write genetic programs that could program a brain? My. My sense is absolutely just.

Just change dopamine receptors and things like that.

There's kind of turning the big knob. So like. So right now there's a. A growing investment in psychedelics. But as a class these are just neuromodulators. They are. They are basically just taking. I've just. I'll back up a step. I've always imagined the brain as like a music studio. The. The big mixing boards with 300, you know, sliders. And you've got a band in the studio. I call the band Reality. And, and depending on how the mix is, you get a reality comes across very differently. Everyone has their own music studio and in their. In their head everyone's got the sliders set a certain way and that's just how they perceive reality.

It's true. There's a lens we all have and it's different and you and I don't have the same lens even though we have common language. And if everyone understood that most people aren't assholes or crazy, they just have a different lens.

Right? But there's a lot of molecules you take and it changes the sliders and it can be amazing. It can open up completely new experiences and most of them tail off in eight or 12 hours and you go back to your old slider positions or sometimes, sometimes the slider stays a little different.

Could we possibly use an MRNA vaccine that turns on production of MDMA inside cells so it just pumps it out constantly for politicians.

MDMA is a small molecule that is chemically synthesized, not biochemically, but there's no reason why something.

Or psilocybin or lsd. I'm asking this a little bit tongue in cheek obviously, but you know, you could do some pretty weird stuff with synthetic biology.

Well, you can basically make anything biology can make. Like that's the. And because again I mentioned at the top of the show we, we don't have the species barrier. We can actually go beyond what biology can make because now we can mix and match from very different points on the tree of life. You know, like taking a jellyfish gene and putting it in a cow. But we're also going into this new area that I think is super fascinating and it's protein engineering. Did you see last year that Google DeepMind essentially solved the protein folding problem with their AI algorithms?

That's a huge thing because we never could figure out how proteins were going to fold and they finally got it right.

Well, to determine the 3D structure of a protein required some super heavy duty equipment that just is not commonly available. Nuclear magnetic resonance machines, et cetera, et cetera, et cetera. Sometimes we have to crystallize the protein just to get a structure. So, so this is a whole field today. All you need is the, there's 20 letters that signify the amino acids in our body. There's only 20amino acids. Now you can take that string of, of letters, it doesn't matter the size, run it through Google's algorithms, DeepMind's algorithms, and get the three dimensional structure of the resulting protein that is atomically accurate. Now that's like just as, as a display of the power of this technology, Google published the the complete protein solved protein repertoires of 21 different organisms, including humans. Essentially any protein sequence we have, we can get a structure that's pretty much as good as anything we'd get off of our actual physical measurement devices, or sometimes better. Now that's wild. But here's where it gets more interesting. That's reverse engineering protein folding. The next step is using AI tools to actually design and build new proteins. So say you wanted just this is an example I've used, but it kind of crystallizes the idea. Say carbon is one of the most plentiful elements in the universe. Obviously what if you want to polymerize carbon into nanotubes? Or what if you wanted to polymerize carbon into diamond? This is not something that nature has done, but, but using tools like Google DeepMind algorithms, the AlphaFold it's called, and AI and a protein synth, a DNA synthesizer to make proteins so that you can actually test the resulting protein in the real world in a cellular system. Now you've got a system that could potentially hyper evolve and make that enzyme. And that to me is fascinating and someone will probably do something like that very soon. Right now there's a professor by the name of John McGeehan in Scotland who for years has been working with an enzyme that was found in a bacterium growing on plastic waste in garbage dumps.

Oh, I heard about this guy. Right, yeah.

And so they found a natural enzyme that the bacteria had, had evolved or, or amplified that could use, that could chew on the plastic and degrade it. It wasn't working very quickly, but like, that's kind of wild. So then they started doing protein engineering to improve the activity. And most recently he's been working with Google DeepMind to amplify the activity. And they're just, it just keeps getting better and better and eventually we're going to be able to like, already they can digest a plastic bottle down to monomers in, you know, a day, which is, which is incredible. So now we're. This opens the door to enzymes that can really start to chew up some of the toxic waste that we thought were going to be around for a thousand years, which is pretty cool. It also opens the door to new medicines. It also opens the door to just redesigning metabolism for completely unique organisms. Yeah, like we're on the cusp of a complete rewrite of the potentials of biology.

I dare someone to use Google DeepMind to create and patent a protein that has exactly the shape of the Monsanto logo.

There is already DNA origami, where people use computational tools and CAD programs to make just about any shape using the DNA molecule. But yeah, it'll definitely go to proteins. Yeah, it'll go to proteins.

That would be funny because one of the problems here is that the way the language is written right now, Monsanto has put tens of thousands of farmers out of business by saying, oh, some of our transgenic corn ended up in your field even though you didn't want it. So therefore you're growing our corn, therefore you owe us the idea that I might either intentionally or unintentionally get some synthetic bio that's patented by someone into my system and therefore someone claim ownership of my biology. Well, those are fighting words, at least where I'm from in New Mexico. So we got to fix that right away. Where ownership is there. And I know Amy and I are going to get into that, but when you and I talk about that, that, that's a very evil idea I just had about Monsanto that would throw the legal system and the patent and IP and trademark systems into all sorts of tizzies that would probably take $1 billion in attorneys. And I love that attorneys need to eat too.

I've, you know, in general championed open source biology. And it's, it's because the, I think the entire architecture around IP and biology has to change. Because imagine like today, if you're a novice program, if you're if you're programming anything, there are great resources to do it. But there's also just a lot of code that people have written that you can use for free like you can, you don't have to. When you, when you start programming, you don't have to write every bit of code from scratch anymore. And this allows us to write more and more sophisticated programs that are, that are pretty bulletproof right out of the gate. Because the hard part, you know, whether it's a sort algorithm or payments or this is how you go and collect an address. A lot of these modules have been pre written. Now the genome is organized in much the same way. A gene is just a module for a particular protein. There are other modules that are switches to turn that protein on and off given different conditions. And how all of this comes together to produce a living cell is still kind of magical, but you know, it's spaghetti code so it's taking a while to reverse engineer. But the current IP architecture doesn't allow us to remix easily. It's not tracking ownership, it's not tracking the evol evolution of code like we get with computer programs where you have all the versioning systems.

We just need Creative Commons, a Linux License in GitHub for biology and we're pretty much done. All these are solved problems, right?

Exactly. And so people have written about this, they published a lot of papers on it. What we haven't seen yet is the complete execution of it where it's just taken for granted. I also. The thing that I think is really important to incentivize this and grow it is that it has to, I believe it has to look a little like the music industry in the sense that the creator owns the content. It's easy to remix and share or play, but you get a royalty. So if you write a really great piece of genetic code, you could retire off of your genetic code collection.

It's an NFT problem actually.

Yeah, very similar.

Made it by law that all, all biological stuff like that has to be nft. That's interesting.

Yeah. And we started to see some people playing around with it. The geneticist George Church was looking to NFT as genome. I think that may have stalled along the way for some. From some of the. No, all the NFT stuff is opening up. But I think it's really fascinating that the intersection of AI and computing where it is today, but also just the new architectures around blockchains and just open books, really. It's open books which I find so fascinating. It could be an open Book or textbook or instructions. Anything that we put on a blockchain is essentially really hard to go and just delete and everyone has access to it. That's really a remarkable technology and I think it's fascinating that it's coming together at this time. We really need to have open standards and open transparency for trust, particularly with something that's universal to us, like life.

Very, very well said and I'm hopeful we get there. So far, the chemical medical industry hasn't been particularly. Their track record isn't very good there. But we have a chance to rewrite that now and I've gone straight for upgrading humanity because that's actually the, the mission statement for my portfolio of companies. But there's other stuff we're upgrading. Like, you know, you talked about fermentation, but what else, what else is going to happen that's maybe a little bit outside of humans that synthetic biology is going to improve or maybe harm?

Well, the one that we're on the cusp of that I think is really going to be significant is the scientists that I've worked with over the years that are developing the synthetic yeast. Now yeast for, for just to give you, you know, the briefest overview is about a billion years more evolved than a bacterium like E. Coli. A yeast cell is closer to you and me than it is to the bacterium. It's, it's got a true nucleus, which is like the hard drive of the cell. It's bacteria. It's more just, it's just mixed in. It's like a bag of biochemists, chemicals. But the, the yeast cell is organized very much like ourselves. And of course, yeast is the foundation of bread and beer. So we, we know how to grow a lot of yeast and we know how to have it make things that, that many of us consume. When you have the ability to reprogram yeast to make molecules, whether it's a drug, whether it's a new flavor, whether it's, whether it's, who knows whether it reprograms your mind. Because you can certainly put any natural, any bit of biology that makes a psychedelic substance has a genetic code that describes how to make that psychedelic substance. You could put that in a yeast. So I think we are going to get a tremendous amount of yeast engineering opening up and that it's going to completely open up a whole new beverage and food industry. So which is fortified medicinal foods or foods that just change your mental state? These are, these are programming the simple organisms is where synthetic biology is today. And we've got so much Room to play with there. Like it's going to keep us busy. But all of that knowledge can be transferred to us and I think we'll start to reprogram us, I mean, humans sooner than most people think. I'm not going to say we're going to do this tomorrow. The first gene edited humans was done in China. There were all sorts of problems with that work. That researcher is actually still in jail for the work that he did and the methods that he used to. But now that that seal's been cracked, more responsible researchers working with, working with parents to solve a real problem, doing genetic surgery will happen. So genetic surgery will come. Biohacking ourselves will have to come as this technology gets more accessible. And really the highest bar, ethically and morally is when we're comfortable enough to use this technology to enhance a child, you know, a child that would be born. No problems, no deficiencies. Because of course genetic surgery will be used to correct children that have serious genetic errors. You know, that's, that'll happen. There's a, we've always used our technologies to fix people that are sick or suffering. But, but enhancement, where there is no. Where it's, it's more guided by our desires is, is a whole new area that, that has the highest bar. But we're going to start to play, I believe, with, with other animals closer to us.

In my world, is unethical not to enhance your children. Well, we have, yeah.

And we do just, you know, to go back to the point of vaccines for a minute. Vaccines are an enhancement of our children. We are loading programs into them so they don't have to have the serious diseases that kids had to literally suffer through, like polio, you know, decades before.

As long as I would say it depends on which vaccine. Right. And it depends on which child, depending on their genetics and whatnot. So I'll say absolutely. Giving your children long lasting immunity against common threats is an absolute thing you want to do. And there's a whole bunch of technologies that we could probably roll out that could do that. You could modulate their cytokine receptors so that they're less susceptible to cytokine storms. You can do all sorts of cool stuff if you just have this palette of things out there. And I'm with you. Like if there was a thing I could do, you know, at conception or a little while after conception that would give my kids robust immunity to all the common things they were going to get without some unforeseen downside. I think all parents would do that. Oh, and by the way, would you double your kid's iq? I probably would, but that might make a very odd kid who can never get a date. Right? Like you have to think about stuff like that, right? I mean, Andrew, you and I know what we're talking about, right? I mean, I finally went on a date, you know, got married, but it took me a while.

Now the problem is we just don't have any experience programming humans, but we will get a lot more experience programming cells and we will start working our way up to humans fairly quickly because the rate limiting step in biology versus computers is really different. With computers, we had to invent everything, so we also had to build the factories that made the chips and we had to have the applications that could use the chips. And there's kind of a whole economic break on that whole system that keeps the doubling time around every 18 to 24 months, or as fast as you can upgrade an iPhone anyway. So.

And also not to cut you off though, just the selfish gene idea from Richard Dawkins. Humans are wired in our biology to be selfish. It's part of our code. So of course we're going to upgrade ourselves because we're wired to do that. And they'll say, that's okay. But I want to call out, in your book, you talk about the Genesis engine. Look, we have a next generation of scientists who are listening to the show and thinking about, what do I want to do with my life? And with this palette of synthetic biology, you can literally go through and repair all of the bad shit that we have done to the environment over the last thousand years, in particular over the last 50 years. And if you don't do that, your children won't survive. So you better fix our soil, okay, you better fix our oceans. And it's not going to happen naturally in your lifespan, but it will happen with synthetic bio in your lifespan, if you choose to do it. It's a survival thing, but probably not for my generation. Just for you.

Well, I want to close that just on the last point. Moore's Law. Limited by hardware, our synbio will be limited by our ability to write programs. Concels can run any program. So it's going to happen and they scale quickly. And they scale quickly, but everyone's writing the same programming language. It's not like, oh, I know C well, I use Java, like it doesn't matter. Like, every single cell runs the same basic operating system in the same operating, you know, like, so we're going to start programming faster and faster and, and already there's A number of applications that are creating billion dollar companies. And soon we'll have trillion dollar companies in the space and they'll be doing something simple that we all need. Whether it's, you know, synbio, toothpaste or what, I don't know. But that's definitely going to happen. But we will start. I agree. We're going to start to think about engineering ourselves in the future and the upgrading kids, well, it will only come when we're really confident we're not going to cause our kids harm. But that will come and it'll come after we've gained more experience engineering other creatures. For certainly anyone that's truly sick, like anyone that is really suffering or that has or will die, those are, those folks are going to really be driving this technology. And more and more people will be coming online to help them and come up with solutions. And the solutions can be today personalized to an individual. The old pharmaceutical model that we can't make a drug unless we can, you know, sell a billion dollars worth of it a year. It's just not worth it otherwise, you know, and it's going to take us 10 years to make this drug. That model goes out the window with synbio because now a small group of people could make for example, a virus to kill your cancer specifically with, you know, for a few thousand bucks.

And that's coming pretty quickly, wouldn't you say?

I would say it's pretty much here.

What's not, you know, three to five years away. Naveen Jain has been on the show as a friend.

Yeah, and there have been cases already where custom engineered genetically based, programmable drugs have been made for kids with life threatening diseases. And it's taken, it's taken a year or two to develop the drug, but under $2 million. So already we've seen parents come together to organize and fundraise and pull together a team to make a customized drug to treat a child with a metabolic disease, for example. And that is remarkable. So I like life. People say, oh, you know, these technologies are only going to be accessible to the wealthy. I always push back on that because just about these technologies when they start to run free are going to be. And I don't mean lack of standard, I just mean just fat. That faster, better, cheaper kind of takes over. It's like cell phones. Everyone's going to have a cell phone. It's just, you know, some cell phones will have more features. And so, so yeah, like this, this is actually, you say that humanity is a failed species. I don't think So I think we're on the cusp of becoming, going from human to superhuman in some ways. But I, I think there is a real big filter that we have to get through during that phase shift. I also think we have to become supernatural. I think we have to really, really defend the natural world from. Yes we do, because otherwise we've already been hurting it. But I think we become quite a lot. But I think if we can, if. I think the idea of protecting the natural world because wow, what a, what a giant library of code that does amazing things. If we become superhuman, where we literally start to re. Engineer ourselves so to remove the susceptibilities to cancer, to age more gracefully, to, to in. To increase our intelligence or balance our intelligence because, because sometimes like we, we just get mentally imbalanced, go into depressions or manic states, et cetera. I think this is, this is what happens this century.

We must be stewards of our own biology and of the environment around us. And we've been that to a certain extent we just sucked at doing it because we don't have the right tools or the right knowledge or the right understanding. And now we're cracking the code to really understand it. What we haven't figured out and what Google even hasn't done, even with DeepMind, is understand the behavior of complex systems, emergent behaviors that you don't predict, which is most of what's going wrong in the environment. You know, you introduce the species here and you didn't figure out that it would make this other species do that. But that's like herding sheep. You can't model herding sheep either very well. But you can do it if you're there and you can, oh, that one's going sideways. Let's fix it. Because you have monitoring, alerting systems and tools to correct problems and that's just how you manage anything. Yeah, so. So I'm feeling pretty hopeful that what you're saying there is true. I'll tell you, without that step of human evolution and without that step being open source and available to everyone, we will fail as a species. And we're right on the cusp. And if there's six elite people saying, I'll just reprogram humanity for my own ends, it won't end well. It just won't. So I'm feeling relatively hopeful. But I got to know, have you done any of these to yourself? I mean, not even one little one?

No, I haven't done any hacks to myself. Like, again, I feel my kids are on the cutting edge of these technologies in the sense that they wouldn't have been born without the IVF, the fertility technologies that we developed over the last 40 years. And even the difference between my daughter, who's 7, and my son, who's 4, was a dramatic shift in the technology. My daughter, who was seven, was, was. We were not offered any genetic testing as parents. We did some just because they were available, but we weren't offered any. There was no genetic counseling, There was no pre implantation screening of the embryos. They just basically the doctor said, I want to put in four embryos. I said, you're nuts. You're nuts. Like no. 2 max for. But it was just like, it was just, it was just using cell biology but hitting with a hammer. My, my son, just three years later, different spot, different clinic. It's like no full, full profiling appearance, full counseling. The embryos were made, they were all tested genetically before implantation. We, we knew exactly boy, girl, but that they'd all passed all the check marks. And in fact, we only had one embryo. That cleared all the hurdles put in. One embryo, a son. So like, that's amazing. But now just imagine two new technologies that we write about in the book that are coming online. Well, a couple of them. One is we're moving to where we can start to make eggs in the lab. Eggs and sperm in the lab. It's called in vitro gametogenesis. That's a game changer because now most of the work in IVF is just getting a few eggs. Sperm, not often the problem, but, but getting a few eggs, that, that can be, you know, 15, $20,000 worth of work. And, and with, with IVG making the eggs in the lab, you can do it from a blood sample. So now that, that opens the potential to have, let's just say a million eggs. Let's just say a thousand eggs. Eggs, let's keep it small. Now you could fertilize every one of those thousand eggs, genetically screen each of those thousand eggs, and now you can basically say, which of those thousand eggs are we going to, you know, turn into our baby? Like, that's not even genetic engineering. That's just selection.

That's just selection.

But let's just say that there's some inborn error of metabolism with those parents and everyone. Let's just say that they're just doing standardized IVF. They've got 10 eggs. They're precious. But every single one of them didn't pass the genetic testing. Now they can. Now we're at getting to the point with, with our gene editing technologies that they can say, look, we're going to take this one and we're going to correct the errors. That's amazing. And now that child will be born that wouldn't otherwise be born. That's where we're today. And that's. People are asking for that ever since the first CRISPR edited baby was produced. Now people are saying, great, can you do genetic surgery to fix the problem that is preventing my child from being born?

I know a very wealthy person who, I believe, I'm not going to disclose who it is who said that he already did that, that he and his wife corrected to genetic things that were in their embryos.

I'm not surprised. First of all, the fertility industry is not highly regulated. It's kept, it's so, so, you know, after the fact, we'll probably get these stories coming out of things that have been done that worked. But, but we're getting to the point in general, we are very accepting of technologies that allow a child to be born that wouldn't otherwise be born. And there is tremendous demand from parents for that. I think one of the, you know, when I, when I put on my future hat and think technologically, where in the future does this go? I see the addition of chromosome 24 to basically every kid that comes out of a fertility clinic. And chromosome 24 being basically another chromosome, goes into every cell, divides, is copied along with every cell division. But it's basically a set of genetic programs that can be activated on demand. And I love that idea. And it's super cheap. You know, it's just adding one extra chromosome standard to every embryo, you know, so. And the reason why, you know, this resonates with me because I remember the early days of computing, you know, when you bought a computer, but there was no Internet to download programs.

I remember.

So they preloaded every program that you might want onto that computer, and all you had to do to turn it on was by an activation code. I see the potential for that with synthetic biology and humanity in the future. But, but really we're in this phase shift where, you know, where we could very well leave this century, you know, starting to become superhuman.

We'll be a different species if we do end this century. It's pretty much written in the cards.

As I read it, man, a lot changed between 1900 and 2000. It's hard to imagine what changes between 2000 and 2100.

It is very hard to imagine. And some upgrades are just required, right? And some of it is really Superhuman level. And I'm very hopeful that we have the freedom to explore which superpowers you want. There's a reason we have the X Men and they're not all the same. You want to be Wolverine? Good for you, man. Whoever that blue chick is, that's all flexible and can. I want to be her. I think she's just got more interestingness.

Well, this is why.

What's her name? Come on. Upgrade Collective. Our live audience knows what's her name? The shape shifting blue one.

Mystique. What?

Mystique. Thank you. I'm choosing Mystique over Wolverine, even though he's my favorite. So there you go.

No, it's, it's interesting because we, like, this is probably the most exciting time to be human and it's going to challenge us. And just like with computers, there are risks associated with it that we have to learn how to essentially just turn the volume down on those. We have to conquer it. And we don't have to conquer it fully in the sense that I think cyber security is a pretty good indicator here. There are real risks with our current computing architecture, but it works good enough most of the time, not for everybody and sometimes there's horrible things happening, but it's good enough that we can, you know, we run the world on it, we need to harden it going forward. But, but I think we, we, we have to take some of the lessons there just for thinking about our biological future. But I, I see us coming out of this century with much more respect for natural systems. A completely new architecture for making medicines, a lot more creativity or medicines and other things biological, not just medicines, but a completely new architecture for programming biology and more and more examples of really cool, amazing stuff that happens. But I've also written that I think we have to have a bigger firewall between the natural world and the stuff that we're playing with. And I'm, I'm not quite sure how to do that today. But I think some of our explorations into space, where basically you're living in a bioreactor closed system, is going to help us generate not only better sustainability technologies, but also learn how to, you know, really keep a hard firewall between natural and synthetic. Because I am fully down with protecting the natural world.

One of the things I appreciate about your Genesis Engine book is you talk about nine risks and I think what you're talking about there is risk number eight. Super mice and monkey. Human hybrids. Super mice or super rats, more to the point, would be incredibly destructive of humans. Rats are already a major Problem for us. Imagine rats 10 times smarter. We'd be screwed.

Imagine cats, just straight up, imagine cats 10 times smarter. We'd be screwed anyway.

We'd have to have, we have to have dogs 10 times smarter. They could chase the cats. It's going to be a total madhouse. Right. But this is the kind of thinking it takes. If you're going to say, I'm going to upgrade my pet mouse, don't put it in the germline. Okay. Seriously, we got to, we got to be concerned about this.

Yeah. You know, I think we will see people hacking themselves, but I think there's going to have to be like an age of consent. And again, I think if you're the first person to try a new genetic program on yourself, you're taking a very big risk. But I, this is why I think that the, there's an opportunity for biohackers, self experimenters to professionalize and share code in their communities the same way, you know, software developers do. I think it'll be a, I don't know. This potential excites me. I'm sure it scares many people, but I don't see it stopping like this. We are hardwired to explore, as you say, and self experiment and hack. So I think part of it is I used to say in my presentations at su, it's going to get faster, cheaper, weirder.

It is, yes. I love that. Faster, cheaper, weirder. It's so smart. So a lot of the Upgrade collective, our live audience are saying like, when can I get this done? I have a heart issue that I really want to work on, or I'm concerned about Alzheimer's and things like that. Is this like a three year thing? Is this a five year thing?

You know, for humans it's a longer course because, because again, we can't, we're so conservative when it comes to, when it comes to humans. There's so many regulatory agencies to bring anything biological online that it's really tough. So for, for anything with humans, you're going to have a long timeline, particularly if you're not. But again, that's assuming some other group or company is doing this to eventually sell it to you as a product or service. Because all the rules there are meant to, you know, protect you as a consumer. If you are, if you have a serious health issue and, and are a technologist and are, you know, and you would be willing to go and learn computing, to go and solve a technology problem in computing. Now is now the window is opening for you to go and enter this field use this technology to essentially treat yourself and because again, no one can really stop you from doing something to yourself. That's or they can, but it gets harder and harder as these technologies are become more available. It does, but, but again products and services are different because we just have such high regulatory bars for that now that being said, we're going to, you know, I, this is one of the reasons why I ended up being so thinking dogs will lead the way with a lot of this stuff because. Because dogs are our four legged family members and we don't want them to suffer and yet their lives kind of go in fast motion compared to ours, you know, seven years per year. And so, you know the stuff around longevity, around health, around heart disease and other illnesses. I think our pets are going to be the recipients of a lot of these technologies before we get them. But we're the. What we learn from working with our pets will, will come back and help us. So it's true.

Dogs and then racehorses, that's where all the good biohacking stuff comes out to be. Truly, almost every laser and electrical device I have was not licensed for humans when I first got it.

But it works great. I like to say I believe in dog. Yeah, yeah.

Very, very well said, Andrew. Thanks for writing a fascinating book along with Amy. And for listeners, this is the first part of a two part interview. So in a couple days we'll release the interview with Amy. So I'm getting kind of both sides. We got our deep tech dive here and we're going to get our futurist dive in the next one. And is there a webpage or place where people should go to learn about your work?

You know, right now I've just got it. No, I've taken down most of my web profiles just because they were starting to get stale through Covid and writing.

Yep.

But really you should I. This is what I do for most of the time. I just make a list of keywords for Google alerts, Synthetic biology, whatever you're interested in. And I just get pretty much every major news article pointing to a paper, et cetera, just from those alerts. If you Google synthetic biology you'll find amazing things. If you're young and a student you're wanting to learn about this, check out the IGEM program International Genetically Engineered Machines. They have. Basically they have. It is based on the robot competitions Us first. It is an amazing community and it's the entry point for many young people to get into the community of synthetic biology. If you're an entrepreneur. The money flowing into Synbio is nuts. More money was invested in 2021 than in the previous 11 years. So it's a really good time to start thinking. If I want to solve a problem with biology to go and build a business.

Well, the time is right and I'm working right now on putting together some AI newsletters for my Dave Asprey page. And I may end up doing a synthetic biology one because Google feeds are relatively limited in what they can do. And so I'll hopefully be able to announce those so we can get some really good stuff around biohacking and all. So if guys, if you just go to DaveAsper.com, sign up for my list, as soon as I get the AI add ons there, you'll be able to say, I want curated news, not just stuff that I write, but very, very focused on just the stuff that I pay attention to based on my lens of reality instead of yours and that we talked about lenses of reality earlier. I always like getting a chance to see your reality through your books and anything else that you end up writing. Are you active on Twitter? I see you've got an account or.

I haven't. I shut everything down to actually write the book and I've just started to post a few things I should say, by the way, if you're really interested in this stuff, buy the book. It's a great entry point. Yeah. And you don't. It's a book about science, but it's not. It's not written for scientists. It's really meant, it's readable. Yeah. And it's about some amazing people and stories and we've got some fun scenarios that help you think about where some of this stuff is going. But really, this is a technology that we're all building day by day. And I think the voice of the biohacker communities in general, you need to be part of the discussion. You need to be communicating to others that might have more the technology skills, what it is that you want or need. Because. But for too long, the folks that were responding to your needs were just really picking and choosing the things they could make the most money with.

Well, I wish you fantastic luck and good fortune in all of the things you're working on. We need the tools for synthetic biology now. We need the right frameworks and the right freedom to talk about them and deploy them because we got to fix a lot of problems in the world and in ourselves right now. And this is probably the only thing we can do. I don't think space lasers are going to do it this time. That's a little bit too 1980s for me, so thanks, Andrew.

Oh, you're welcome, Dave. And I just. I'll leave one last note. You know, one of the easiest things to do is just back yourself up. Biologically, I have this strong philosophy that as long as you have cells in a tube somewhere, you're never really quite gone. I'll leave, I'll leave. I'll close on that note that, you know, there's always the opportunity in the future to to do upgrades.

Yep, we're going to build superhumans one way or another. Upgrade Collective Live Studio Audience thank you for helping me crowdsource the questions that we got to ask Andrew, are you listening to this? It was the Genesis Machine by Andrew Hessel and Amy Webb. A book really worth reading. You think that knowing about crypto makes you cool? No, that just makes you average. Knowing about synthetic biology makes you cool. I'll see you for the second half of this interview. You're listening to the Human Upgrade with Dave Asprey.

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