How to Relentlessly Prioritize Your Life – Jesse Itzler : 1121

4 Jan 2024 · 89 min
Episode

4 Jan 2024 · 89 min

0:00

In this Human Upgrade podcast episode, host Dave Asprey interviews entrepreneur, author, and ultra‑marathon runner Jesse Itzler. The conversation weaves together three main strands: (1) Jesse’s philosophy of willpower, illustrated by his ultra‑marathon and "Everesting" challenges, and how that mindset translates into business resilience; (2) his systematic approach to life organization, which includes a giant visual paper calendar, a yearly "misogi" (a single defining adventure), six mini‑adventures spread across the year, and quarterly habit‑stacking, all supported by two personal assistants who handle personal and professional logistics; (3) his bio‑hacking and longevity focus, from early self‑experiments to current investments in gene‑therapy, stem‑cell work, AI‑driven Upgrade Labs, and daily practices like infrared saunas, cold plunges, and selective fruit consumption. Dave interjects with his own productivity experiments—deleting his inbox, critiquing GTD, and emphasizing delegation of low‑value tasks. Both guests stress the importance of bandwidth, visual planning, and deliberately choosing high‑impact, low‑aggravation activities to free time for family, adventure, and health. The episode ends with a discussion of future longevity retreats and a light‑hearted exchange about personal quirks (tooth powder, humor, etc.).

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