Unlock the Master Molecule: Glutaryl for Superior Detox, Skin, and Energy : 1205

I gotta ask you something else.

Yep.

Now, I heard about this first from Korea, which is the world of like the most amazing skin care stuff. They always come up with, you know, snail serums and all kinds of things, but butthole bleaching?

Uh huh.

Do you know about this?

Yep.

So people have been using glutathione in doctor's offices to lighten your butthole. Now, I can say I don't know the color of my butthole because that seems like it'd be hard to see that I don't understand, you know, the, the need for this, but apparently it's popular. Will this bleach my butthole? You're listening to the Human Upgrade with Dave Asprey. Today is a special Upgrade Spotlight where I bring you a scientist and creator who's made something new and interesting and worth your time. You may have heard me talk over the last dozen or so years of biohacking about this compound called glutathione. In fact, back when I weighed a lot more than I do now and I was having really bad brain fog from toxic mold and chronic fatigue, I took the first commercially available glutathione product, which tasted really bad, but it did help me, and it's something that I've taught millions of people. Pay attention to, is how do you get glutathione into the body? When I was at Bulletproof, we even made a capsule that could raise levels a little bit. The problem is it gets digested in the stomach and it doesn't absorb very well. And you want glutathione because it's a master antioxidant. So what I did for you today is I've got a master of glutathione here for you. His name is Nayan Patel and he, he's the founder of gluterol. And this is stuff that you put it on your skin and it works better than an IV at getting glutathione into your cells, so it saves you a ton of money. But this, this guy knows everything about what's going on with topical absorption of things. So we're going to go deep on that for you. You're going to learn the role of glutathione and what other things you can do with this transdermal technology, especially on your face. The reason I'm into this right now, I've always been a glutathione fanboy, but you might have noticed I used to weigh 300 pounds. I'm 4.8% body fat right now, and I get to show off my tattoo, the caffeine tattoo. But, like, I'm completely cut in a way that I've never been. This is like competition level. If I was into that, and I'm not really trying to do that. Problem is, I have enough skin for a fat person on my face and I don't like it. So I'm like, how do I make my skin tighter and how do I increase subcutaneous fat and how do I just manage the toxins of flying all the time? So we've got the world's best guy for this. Welcome to the show, Nan.

Well, thank you for having me today. I appreciate your time and what you've been doing. So I'm a big fan of you. So I'm glad I'm here today with you.

All right, this is your second time on the show, and we're going to repeat a couple questions for new listeners, but for the most part, we're going to talk about new things that people don't know.

Okay?

All right. RO Wellness makes gluterol, Gluteril, Gluterol. Gluterol. This stuff is ridiculous. You spray it on and you've got clinical studies that show it raises glutathione in the cells. Why do I care?

So your body has no receptors to actually accept glutathione, or for that matter, any kind of peptides or anything else into your cells inside your body can take the peptides, break it down, absorb the amino acids and use it up inside the body. But there's no receptors to accept in full as complete. So we have figured out technology now that can mask the whole system and basically deliver through the into the intracellular levels using the dextrin technology, put the glutathione inside, or for that matter, I can put 2, 3, 4, 5amino acid chains, whatever you want, into the system and deliver intracellularly for the very first time for the body to be ready to use up right away.

Wow. If you've heard me talk about liposomal glutathione in the past, this is glutathione in these fat bubbles.

Yeah.

And the reason that you would do that is it can absorb past the gut lining, but. But it gets into the blood and it can't get into the cells.

That's right.

And what you've done is made a next generation delivery system which uses your dextrin technology to make smaller things that will go into the cells directly from.

The blood, into the cells, into the intracellular levels. Yes.

I gotta think about this. If rubbing this onto my skin can do that. What do you think of these endocrine disrupting sunblock creams people use?

Well, yes. I mean, there's a potential that you can send different molecules through this technology into your bloodstream really fast.

Well, it looks like any kind of fat rubbed on the skin with toxins in it. The toxins go in?

That's right.

It follows that you could then rub good things on the skin that would go in. And if you're using the delivery system that you invented, it'll go in not just to the blood, but into the cells. What happens when you raise levels of glutathione inside a cell in the body?

So that's been very interesting because the first thing we look at it is, what if the glutathione goes into the cells? What does it do for us? First of all, it raises the glutathione levels. But more importantly, the body sees that raising glutathione levels is so high that it doesn't need to produce this tripeptide. So he uses that energy to produce other peptides, other molecules, other proteins that he has to do. For example, glutathione is just a small three amino acid. Peptides uses two ATP and one molecule of nad. So now if it does not need that two molecules of ATP and one molecule of nad, it can use that energy to produce other peptides. For example, muscle, muscle needs what, 6,100amino acid chains coming together to produce muscle acting. Right. It's a lot of energy required. Anything that I can spare on making glutathione, we can use to make some other things in the body.

I love what you just said there. So there's a certain amount of electrical energy available every day. If your mitochondria work better, you can make more electricity. But end of the day, the body says, do I make stress hormones? Do I fold proteins? Do I make muscle? Do I make inflammatory signaling molecules? Do I make a melanin or melatonin inside the cells? And it's gotta decide. And there's a very elegant system that does that. So if you're saying body, you don't have to worry about making glutathione right now. What else will you make?

That's right. So when you do that part for the first couple of weeks, you don't notice much difference other than everything starts functioning normally or better in two weeks. Within a very short amount of time, you're going to feel an excess ATP in your body. So you have this extra energy. It's not the coffee energy, but I feel better. And they cannot pinpoint down. I get calls every single day. I said, you know, I've been using glutathione for a couple of weeks now. I feel good about it, but I cannot pinpoint down what I'm feeling.

It's like. It's like more life energy.

More life energy, Exactly.

It's kind of strange, but the body says, do I make a protective antioxidant or do I make ATP? And if it has more energy available, it can make more ATP. Assuming everything else is working.

Exactly. And the body produces a lot of ATP every single day. And so it needs to divert the energy to do the right things. Of course, glutathione being the most abundant molecule in the human bodies, it uses to produce that. First, it's a very simple reaction. 2 ATP is very easy to do that part, so it produce abundantly. But if it does not have to.

Do that part, it frees up longevity behaviors. Yes, got it. Now, what does glutathione do for your skin specifically?

So skin has the highest amount of oxidative stress. Besides, your brain is in your skin, right? Well, skin is probably the third organ. The second one is probably liver, I would say.

Yeah.

But skin is exposed to the environmental toxins the most. And so the highest exposure that we have to oxygen stress is your skin. Unfortunately, the skin, you can feel the skin that not being so healthy, but you can also see not being so healthy. So we can see age spots, you can see liver spots, you can see discolorations of the wrinkles or not having the pinkish hue or skin seeing all dried up. So glutathione actually does not do any of those things to help it. But what it does removes reduce oxidative stress down, and so the skin cell starts healing better. And the skin can basically heal in about 30 to 45 days. So it's much, much faster that way to do that than. Than other parts of the body.

And this is why you've launched. In fact, this was just in Vogue, the RO Wellness antioxidant serum, which is glutathione for the face. People use this for a month or two, then they see less dark spots, less pink, or at least less unhealthy red spots.

Unhealthy red spots, fewer dark spots, fewer discolorations. They wouldn't say the fine wrinkles go away. And of course, Vogue is all about beauty, health and beauty. For them to launch a whole article on glutathione specifically, my technology, we are very Happy to do that part. But at the same time now people are looking and say, hey, what is this glutathione? I've been using vitamin C my whole life. What about this glutathione now?

And vitamin C has a really big downside that no one talks about. Oxalate is a major toxin in humans and it comes from spinach and raspberries and almonds and kale and all that kind of stuff. And different people get it from different sources. But it's in my opinion a major untalked about cause of aging. And if you're taking more than about 250 milligrams of vitamin C, it'll raise oxalate, which causes kidney stones and causes a bunch of other health problems. So. So if you can get vitamin C in through the skin to protect the skin, it's gonna make a difference. Which is why vitamin C is in one of your serums. But it's not at the doses that cause this problem. If you just take a bunch of pills of it.

Right, exactly. And you nail it. Right, exactly right. 250 milligrams. So my glue, my vitamin C park is how much?

Nice.

250 milligrams.

And it's topical. It's almost like you did your research because you're very knowledgeable. It's one of the reasons I love interviewing you.

We did the exact same thing and we use the pure ascorbic acid and something that we don't talk about it all. Ascorbic acid in United States, guess what it comes from?

Comes from black mold fermentation.

Yeah. Mainly from corn. Right.

With all the free glyphosate you can mark.

Exactly. So guess what? Being a pharmacist and I know what the downside for that is going to be what I did my ascorbic acids, Guess where it comes from.

Are you getting it from a sugar molecule from beets? Probably.

That was my second option.

Okay.

That was a little bit more expensive to get it out.

So where do you get it from?

Tapioca.

Oh, interesting. And let's see. Do they spray glyphosate on tapioca? They don't.

They don't.

Right. And there's no reason to get it from beets besides a lot of beets or GMO these days.

Anyway, that was the biggest thing I wanted non GMO products into my, my product line. And so now I don't tell this to everybody and anybody because nobody understands what I do. I'm basically self regulating myself because nobody asked me these Questions. But I just do it because it's the right thing to do for myself. And if it's good for me, it's going to be good for my patients. And so we use the highest grade ingredients in our products for the very reason, because as I said, if it goes to your skin, it can go in place, can go to your skin as well. So I had to make sure all the ingredients that I get are injectable grades or pharmaceutical grades, so to speak.

Do you mind if I ask how old you are?

53.

So look at your skin. This is ridiculous. You have an unfair advantage. You have dark skin. The more melanin you have in your skin, the less it ages. So us white guys have probably the worst skin aging. It's pretty well known. Some of my black friends say black don't crack. I'm like, you guys are right about that, man. But I mean, your skin is just like flawless on your arms. And how often, like, do you put the serum on your arms? You just spray it. Like, how does it work?

So I do use serum on my arms. That's why I shave my arms too, because I don't like the hair to mess up my glutathione regimen. So I just use the glutathione in my arms. I use it on my belly sometimes. But I also use the morning cream on my arms every day because that has the CoQ10, the Carnosine and the DME. And so that really helps smooth. I feel very smooth on my skin every day.

It's funny, I talked to Brian Johnson about this. He was on the stage at the biohacking conference and he's removed all of his body hair. I'm like, why? Personal preference. And I will tell you, I don't like getting all the lotion stuff that I use all over. Right. So keeping the hair at a minimum. I'm not that hairy anyway, so I think there's actually a case for that. Also. This will get super esoteric and outside what I was going to talk about, you've heard about possibly the stories from the Vietnam War where they hired, I guess recruited American Indians, which is what they called them at the time. I'm not sure that appropriate word. Different Native American friends of mine want different names. So whatever you like to be called that. But they brought them in and said, you're the best trackers in the world. But they made them cut their hair and they. When there's. I can't track, right, because they're using their hair as like an electrical Sensing thing. So then the next round of recruits, they let them keep their long hair and then they can track. So I think hair on the body is picking up all these non native EMFs and it's probably not something that humans want right now. Plus, if you're using electrodes, which I do all the time, or you're using transdermal delivery systems, hair is a pain in the ass.

It's. Yeah, it is.

I'm with you there because, like, greasy hair is gross. Haven't quite shaved my arms, but who knows? What do you think about that? The EMF hair connection?

That is a little bit far out of my wheelhouse because as a pharmacist, I'm wired to look at chemicals versus the electricals. Yeah. But in the electricals I'm a little bit of. Wait a second. My brain is not wired up to think along those lines right away.

It's so fascinating to me because it's clear right around the founding of the AMA that there was a war between the electrical medicine people. And this is like Royal Rife and Tesla and then the chemical people, backed mostly by Rockefeller because he figured you can turn oil into chemicals, into pharmaceuticals and sort of like the. The chemical people won. But the reality is we're both electrical and chemical.

That's right.

And I'm always working in biohacking to bring in light and magnetism and all of that. And those don't work if you don't have the right chemicals.

True.

So it's this complex system. All right, now how many sprays of this is your. Your primary spray, the gluterol spray? How many sprays do I need to do?

4.

All right. So I'm going to do, if I can, the lid. I should take the lid off. There we are. All right, now I just rub it in. How long does it take to absorb?

Takes about 30 seconds to 2 minutes, depending on. I mean, your skin is pretty dry, so it should be really pretty fast.

I mean, I did put lotion on this morning, so.

Oh, that. It might take a little bit longer. Take about minute to two minutes. It'll completely dry up.

Okay.

So right now it's still wet. It's still wet. So that means you keep on rubbing it in. Okay. Until. Until it completely died. If it gets too sticky, that's when it gets activated. Then you to pet it down or just gently rub it.

Okay.

And.

Yeah, it's getting sticky.

Yeah, it's getting very sticky. So the sticky part is actually what's getting activated now. That's the dektrin that's the dextrin molecule. And so we don't talk about dextrin molecule a whole lot because there's nothing too much published articles that's out there right now for the dextrins. But the whole idea behind dextrin is that it needs to get activated to get into the intracellular levels because it binds to the ACE2 receptors on your lipid rafts on your cells to deliver the molecules through that channel. Now, that particular channel is how we get nutrients inside of our cells.

What's the difference between dextrin and dextrose?

So dextrose is pure sugar.

Okay.

Dextrin is part of the sugar molecule, but then it comes into different formations. Some are cyclic, some are clusters. So it comes in different formations. And based on different formations, you can put it inside other molecules to kind of store them. So that's the whole purpose of it.

Now, listeners may know dextrose is corn. Glucose.

Oh yes, right.

And glucose is, is not bad for you. In fact, you die without it. That's why your body makes glucose if you need to. So I full respect, if you're, you know, on a keto or carnivore thing, you might want to cycle that. That's why I wrote the bulletproof diet. You know, it's okay to be full on keto with no glucose other than what your body makes, but doing it for a long period of time depletes things. So it's. And also your gut bacteria get off. So kind of go back and forth. And I know that I just pissed off all of the hardcore carnivores that say you only need meat. My experiments with that yielded waking up dozens of times a night without knowing it and new food allergies because I got leaky gut. Because the good gut bacteria, when they have no food, they get pissed off and they eat you. So like, you know, be carnivore for a month or something. But if you're doing that, do you.

Need more or less glutathione being on carnivore diet?

Yeah.

So I'm not sure if the diet has anything to do with being increased oxidative stress or not. So if you are on a high sugar, high carb diet, then yes, you will. Your oxidative stress is high.

So vegans need to have more.

Yes. If you're carnivore, you may need more energy to break down the. Basically unfold the proteins. Break down the proteins. So you need more energy. So you will need the glutathione to spare Some of that energy so the body can function.

So you can do gluconeogenesis more effectively.

Exactly.

I would say there's a huge amount of inflammation that comes from eating most plants. But not all plants are bad. Some of them are medicinal and useful, and not all carbs are bad. Some of them are very useful. But if, if you're in your first week of carnivore, you're probably experiencing less oxidative stress because you got rid of plants that were causing inflammation. But if you have your glutathione levels high, it's going to help you with lipopolysaccharides. That's right. And lipopolysaccharides. And we're getting really nerdy here, so I'm going to try and explain all this. When your gut bacteria are stressed, which happens when there's no carbs for most of them, they, in response to stress, they make toxins like, hey, you know, this is my cheese, this is my body, like anyone else around here. And those toxins are called LPS or lipopolysaccharides. They're what causes food poisoning and they cause brain inflammation. What helps your body process lipopolysaccharides is glutathione.

That's right.

So if you're going to change your gut bacteria by avoiding carbs or maybe by being vegan, either way, more glutathione is going to protect you from the bad things that'll happen in your gut.

True. Exactly. So you just applied right now? Five minutes ago?

Yep.

Okay.

I can't feel it anymore. And maybe slightly more tacky.

Well, no, you gotta rub it in smart water until it's completely dry. Okay, so what happens is that most people, within the first 15 minutes or so, if they have a gut issue, they'll have stomach pain.

Oh, really?

They have reversivia, nausea. They can get diarrhea from it, too. And the reason is because of what you just said. When the diet has high levels of lps, right, you're gonna have issues with your gut. And that, by the way, within two weeks that all the symptoms goes away. That's when you know that your body is now on the healing path.

It's interesting, some skeptical people will say there's no such thing as detox or detox reaction, which is. It's nonsense. Anyone who's had heavy metals or toxic mold or any of these things, there's times when you take a little bit of activated charcoal or some glutathione and you don't feel better, you feel worse. Because the body says, finally, I can drop this stuff. So it actually releases more of the toxin because it's now able to metabolize it. And so if you did try glutathione and you're saying, wow, this is a lot, you just do one spray for a little while instead of four sprays.

And you ramp up, you ramp up so you had no side effects, so you're fine. But most people, if they have an issue, they will do maybe one spray twice a day, then go to twos, then the three and fours. But we always said, hey, go four first. And if you have any problems. So most of the issues are what? Headaches, because high oxidative stress is in your brain. That's the first thing that people notice. The second thing people notice is the stomach issues. Stomach pain, nausea, things like that. Diarrhea maybe. The third thing is rashes. That's a herx type of reaction that's happening. Either one, whatever happens, produces a dose down, really just goes down to what your body can tolerate because there's no point plowing through the problems. There's no gold medal at the end of the problems when you solve it. Right. So please don't suffer. Reduce the dose down, be safe, and then increase it slowly over three to seven days and then you're fine.

One of the things that I learned when I was really deep in toxic mold and chronic fatigue syndrome and all that, is that there's no reason to suffer as you're healing.

Yeah.

The first time I went through all this stuff, I mean, I felt like crap for a couple years as I was trying to do this, because I didn't understand detoxing. And one of the issues is that if you take a substance orally, like say liposomal glutathione, the old form, you take that and you take activated charcoal, which absorbs toxins, it absorbs the glutathione, it doesn't work. But with the new form that you have this gluterol, what you can do is you can use that topically and you can still take charcoal. Stomach.

Yeah.

And then the charcoal will stop a lot of the detox reaction that you could have. So all of a sudden, you know, there's very high performing people. I was talking with one very major actor who had just profound levels of toxic mold. Like, how's he gonna get better? Well, getting glutathione. And you could do it intravenously, which is expensive and you gotta get stuck, but it doesn't enter the cells as well.

No.

If this sounds interesting, I think it is. Go to ro wellness a u r o wellness.com, use code DAVE10 and get 10% off. Just as a way of saying thanks. So is there an upper limit to how many sprays of glutamel I can do? What happens if I just cover my body in this stuff every day?

No, you can't do that. What happens is that you're going to get herxheimer reactions.

Or.

Either that or what you're going to happen is your body's going to go overboard and you have zero oxygen stress.

Yes.

When you have zero oxidative stress, the reaction is identical. You will have rashes, itching all over the body.

Zero oxidation means you're not making energy. Right. So if you suppress the ox redox reaction that is the foundation of life by over consuming antioxidants, you are going to run into problems.

And that's exactly what would happen. So I experiment all the time. Like I flew in yesterday. So I used almost 20 sprays because when I fly, I need a lot more. But when I get back home, I'll go back to four sprays twice again.

Imagine that when you're doing something that increases oxidative stress, you should do more gluterol.

That's it.

Same thing. I use something called ketone IQ when I fly because we know that ketones protect you from ionizing radiation. I don't take it every day. Right. I take it if I'm going to fly. And I love supporting myself with glutathione when I fly. I haven't made a practice of spraying this on airplanes, but you've convinced me to do that now because I fly a lot.

Yeah.

Now what about after a workout? Is a topical glutathione like this, is it going to suppress the benefits of stress or oxidative stress from exercise?

So it's not gonna suppress the benefit. But the thing is, you don't apply it before you exercise, you have to apply it afterwards. Because exercise is actually you're consuming a lot more oxygen, you're breathing heavily, your heart rate's really high, and so you are gonna produce a lot of oxygen stress. Now that extra stress is actually necessary for you to become resilient. But what happens is that once you're done exercising, then you go into recovery mode and you can only exercise tomorrow again if you recover today.

Wow. You should be a spokesperson for Upgrade labs. We've got 30 locations either open or in the process of opening. And we're Blowing gyms out of the water. It's like I've been a gym and there's no mirrors there. It's like, guys, let's get the signal in and then let's recover. Because the speed of recovery drives speed of adaptation. That's right. Right. And you're showing the same thing with glutathione. So you exercise and then you use glutathione afterwards.

So most of my athletes, they use the Viva plus version of this thing much, much stronger than. We don't recommend this for everybody, but people that have very high needs of glutathione, especially my super elite athletes, my Olympic athletes, my NFL players and NBA players, they will use post workout so they may work out, they may do the cold plunging, whatever they want to do, and then they'll spray on the glutathione. And literally in about half an hour or so, doxy stress is completely quenched. And when that happens, the recovery is much, much faster. They can, I mean, I have a 40 year old NFL quarterback that used it for a couple of years and amazing results happen because he could, he can actually keep up with those 20 year old kids.

Sounds like Nick Foles. You probably can't say no. Nick's a friend who just retired and has been on the show a couple times. And when he got the super bowl mvp, he was using pretty much all of my products. And I love it when I see these professional athletes in their 40s who are using natural abilities of the human body to perform at a level that was unheard of. Yeah. We've also got the Bryant brothers in tennis. Same thing like how are you beating people half your age? It's because they understand oxidative stress and recovery.

Most of my 35 year old ball players, I tell them one thing, I said, hey, if I can give you one more season to play, what is it worth to you? Yeah, one was seasoned.

Yeah. And I mean it, it's not unreasonable for a professional athlete to spend a couple hundred grand a year on their, on their biology because they're making way more than that. And I, I'm getting up there. I've spent $2 million actually probably closer to 2.5 now over the past 20 something years. I don't think it takes $2 million a year. No, that's a little bit excessive. But investing that over time, the, the results are, are compounding. You get compound interest. So I, I am grateful that I did some of the early stuff and now I'm doing gene therapy. I just did a Circadian, a central. A central aging clock reset, which is, you know, focused ultrasound and stem cells in my hypothalamus. And the differences are incredible. And I'm willing to do that because I'm a professional biohacker and I write books about it. But also I think it's worth it. But for listeners, what I also used to do was spend $500 on a Glutathione IV. I've done probably, I don't know, 500 of those over my life. And now we're like, oh, look, a spray. What does this stuff cost anyway?

120 bucks.

120 bucks. And this spray is enough for.

This is four sprays twice a day, basically getting two IV treatments per day. Literally.

Got it. And this lasts for how long?

30 days.

Okay, so a 30 day supply for 120 bucks, which is less than the cost of one IV.

And.

And you're getting more into your cells than you get from the IV twice.

A day, every day.

Guys, do you remember when, over the last years, I keep saying we're doing the crazy billionaire stuff to show that it works, which always brings the cost down. And this is one of those things where four sprays of this is going to cost, doing my math, right, two bucks. About two bucks. And this replaces something that was probably 200 bucks if you got a good deal on your glutathione.

Yep.

Right. And some of my functional medicine followers, and there are many, and thank you doctors for listening, you might be like, what the heck? You know, I make money on glutathione. You can still do Glutathione IVs.

You can still do it.

Yeah, in fact, I do. I get a phosphatidylcholine IV and I follow with glutathione because the needle's already in me. But that doesn't mean that I don't use Aura Wellness as well.

Yep.

Is there a risk of turning down my endogenous production of this?

So that is only an issue if you're dealing with endocrine hormones.

Okay.

This is not endocrine hormone. Okay. So endocrine hormones like thyroid or testosterone.

Thyroid or something.

Insulins, cortisols, hormones, all those things. Testosterone, estrogen, progesterone, all those things. Because turning down endocrine hormones, there is a signaling method that come from the pituitary, which is get signal from the hypothalamus. So if you disrupt the signaling pathways, then the body will tend to forget when it comes to glutathione. There's no signaling. It doesn't get a message from pituitary to hey, produce more glutathione. It's a built in system that we already have to produce peptides or tripeptides or quad peptides or muscles. I mean, you don't have to get a brain to tell you to produce muscles. No.

Okay.

So that's why there is no negative feedback, so to speak, to produce glutathione. And if you do shut down your own production because your body has enough, is going to use up all that energy to do something else.

And you're not going to lose the ability to make it because it's such a foundational system. You can't lose that ability.

You can never lose that.

Okay, that is really cool because that's something I've always been concerned about. Some of the older advice in glutathione was, you know, don't take it on weekends or something. And I think that's true of general antioxidants like vitamin C or something. Take a break, you know, once or twice a week. But I don't think you need to take a break with this. And it may even be beneficial though, you know, every now and then. Let your body feel some stress. Right. So should I take a day off a week when I'm using topic I.

Forget to take once in a while anyways.

Okay.

Plus if my stress levels are low, guess what, I'll go to hyperbaric chamber. I'll go to something else. I'll do something crazy anyways to increase my stress levels.

You get this. At such a foundational level, doing the same thing every day is a terrible strategy for almost anything. I set aside about an hour in the morning for biohacking and I don't know what I'm gonna do. I'm gonna do something right, and it doesn't have to be the same. And if I'm working on a certain part of my body, I'm gonna do more of that. But you could spend eight hours a day on longevity. The problem is then you need to live 33% longer just to catch up because you weren't spending that time doing something you wanted to do.

The live experiences.

Yep. So for me it's about how do I have the most benefits per minute per unit of suffering and per dollar. That's what I'm teaching people. Because if you have to suffer a lot, like if we say, hey, you will live 20 years longer every day in the morning, wake up and punch yourself in the face as hard as you can. 10 times. No one on earth will do it. That's right. Because it just sucks too hard. And recognizing that friction and pain and inconvenience are real expenses in longevity and human performance. It's there. And I'll tell you, getting an IV and driving to a doctor's office is a lot of work compared to spraying something.

True. Okay, true.

But I gotta ask you something else.

Yep.

Now, I heard about this first from Korea, which is the world of, like, the most amazing skin care stuff. They always come up with, you know, snail serums and all kinds of things. But butthole bleaching. Do you know about this?

Yep.

So people have been using glutathione in doctor's offices to lighten your butthole. Now, I can say I don't know the color of my butthole because it seems like it'd be hard to see that. I don't understand, you know, the need for this, but apparently it's popular. Will this bleach my butthole?

It's not a bleaching cream. So let me put it this way. So we have. Actually, we have a lot of ladies using it for the genital area as well to lighten it up a little bit. So they have used that for that area as well.

Probably absorbs better. Right, Right.

Absorption.

It doesn't matter.

It doesn't matter. It doesn't have to go through mucosal membranes at all.

Most of the steroids, things like progesterone, things like testosterone, any of those things, estrogen, you put them first on your vagina if you're so equipped. And if you're a guy, it's the scrotum, followed by perineum because there's more mucous membranes there, followed by armpits. Yeah, like, that's where you would do it. But there's no reason to put this there unless you're trying to enhance that part of the body.

Exactly. And so we have a lot of ladies. I have a lot of customers in South Florida, in fact, I don't know why South Florida, but that just happened to be a few doctors over there using it to bleach vaginal areas.

Interesting.

Yeah. It's not a bleaching cream, by the way, but it just lightens the.

Lightens?

Yeah, yeah, it lightens the skin up a little bit. So they are using that up. But nobody on a butthole yet. So I'm sorry.

Oh, got it. So I probably won't be your first guinea pig there because I don't even know how you track results or, like, get in the mirror and bend over. But I do know that that's a thing. And it's not a small thing.

It's not a small thing.

I'm probably the opposite. I'm more of the butthole sunning kind of guy. Where. I was in the New York Post for that a while ago. It was a humorous post saying, you know, warning, don't get a sunburn. And it just. It's become a thing. But is there any effect on tanning? Like, if I. I do spend 20 minutes in the morning in sunlight, sometimes I even take a peptide that causes more rapid tanning. So I have a protection. Is it going to block tanning effects from the sun?

No, it's not, because the tanning is actually coming from the UV exposure. So that is not gonna block the tanning effect. What it is gonna do is gonna block all the oxidative stress that's caused by the UV lights.

Okay?

So that's the only thing that's gonna happen. So, yes, I do recommend people to go in the sun every day.

Okay.

In fact, a little bit of sun exposure will also increase your glutathione levels in your body. Right. Because what happened? The sun gives enough energy to. There's an oxidized glutathione in your body that gets regenerated again with the help of sunlight. But just 5, 10 minutes, 15 minutes at the most, is enough to rejuvenate all the glutathione back in the system. So am I going to use glutathione right after sunbathing? Yes, totally. Yes. But for sun exposure for 5, 10 minutes? No. Because that is actually going to raise your glutathione levels naturally.

Anyways, I believe that sunlight is necessary for life. I don't use sunscreen except mineral sunscreen on my face if I'm going to be out for a long time. And we know that even normal doses, you know, up to 20 minutes of ultraviolet light reduces wrinkles, it reduces nearsightedness, and it raises dopamine in people.

Yeah.

So it's like if sunburns are bad, that doesn't mean no sun is good. And if you did get extra sun, having extra glutathione is a really good idea. If you've got normal sun, you don't need it.

So what I do. I have a morning routine. So if I have the. Yeah, I have the morning routine.

Okay. You have a bunch of new products that are kind of cool.

So. Yeah, let's talk about that one. This is my morning routine. I Have the vitamin C and the cream that goes on top of it. And the reason is because I'm not here to block the sun coming to me. But what I'm doing, I want to neutralize all the harmful effects that the sun causes. That way, there's no chemical left on my face. So I've washed the face, put the serum on, put the cream on top of it. The cream is CoQ10DME carnosine. So basically, keep on regenerating glutathione. This also helps regenerate glutathione. And so in the morning, all I'm trying to do is trying to protect as best as possible without using any sunblock or sunscreens. And my skin is a little darker, so I can afford to do that.

Okay.

If a little bit lighter, maybe you may need some minerals to kind of block some of the waste. Yeah.

You don't have a problem with sunburn?

I have no problem. I have never used a sunblock, and.

I. I don't get sunburned anymore because I got rid of the omega 6 fats in my. My body. My ratio is appropriate. I eat mostly saturated fats and some monounsaturated in trace amounts of omega 6s, and I take my astaxanthin. So for me to get sunburned, it would probably take eight hours in the sun.

Yeah.

And I have a tan because I use tanning hormone. So my. My. My body's production is very good. My kids live in Canada, though. God, they're butt white. I mean, they. They can't be in the sun for very long. It's going to take them a while to build up a tan. I'm like, that's embarrassing because you got to get some sun. But they're like, there is no sun in Canada. I have a practical question. So we've got, okay, the. The gluterol spray that you use just to raise glutathione. It's like a replacement for an iv. Okay. That one's easy, but you've got four bottles of stuff. I smear this on my face. Can I just mix it all in my hand and put it on my face? Or I put one on, then the other, then the other.

So this is a day. This is the day routine.

Okay.

This is the night routine. And there's a madness behind this thing, because in the day, I don't want to use cyclonestrogenol resveratrol in the daytime because this thing actually takes time to repair the DNA. So this way, I want to work it overnight. So this is a nighttime routine and I don't want sun exposure to it. So I use the glutathione and the resveratrols and the cyclonestrogenol to help repair the DNA. During the daytime I want to protect as much as possible because daytime we're exposed to sun pollutions, chemicals and things like that.

It's still two creams though. Can I mix them in my hand and smear it on?

This is serum and a cream. There's only one cream.

Okay.

There's other ones. Serum. So you like the insulin.

What goes on first?

So if the serum goes first, the serum is sticky and all those things. So you put the serum on first, dries it up, put the cream on top of it and you're done.

And if I'm lazy and I mix them in my hand, this may or not. Is it gonna work still?

It'll still work. It'll still work. It will not mix very well, but it'll still work together.

Okay.

Yeah.

I'm always about saving two minutes in the morning.

I know. And so for guys, by the way, this is the first time it's been recorded. I'll tell you. I have a cream that's ready for the guys because I'm a one cream kind of guy myself. I have it ready. I have been told not to launch it yet because it's just too expensive for the guys to buy it. And I would not cheapen it because I will not reduce the chemicals in there.

For a certain kind of person who listens to this show, you value your time and energy. So would you be willing to spend twice as much for one cream that does what two creams would do? Well, you're actually not spending twice as much because if it was 60 bucks for each of the two creams and then you spend $120 on one cream that had both in it. It's the same cost, it's just less time.

Well, the problem that I have is that I don't. I do not want to reduce the number of chemicals inside or the ingredients inside at full concentration. And so the production for this product is actually more than double to time. So it is more expensive to combine them together than to use separately because the reaction time in my bioreactors that I produce in it, it is a beast. So that's the only problem I have.

You're also reducing packaging and pollution and also.

Absolutely.

I'm all about, especially on skin care, make it easy. Because I know a lot of my women friends, they have Seven different things. How do you even know which one to put on first? It's kind of overwhelming, right?

Yeah. So this is for. Mainly for women. The four is maximum. Two serums, two creams. Hopefully they can do it.

I don't think it's mainly for women. Maybe women are more willing to do it. Guys, if you start doing this in your 20s or 30s, you will look like you're in your 20s or 30s for an extra 10 or 15 years. It's totally worth it. Just make it easier.

Make it easy. I would love to. I would love to.

All right, sign me up for the. The all in one.

I have in my bag my stuff.

Nice, nice. Custom made stuff.

Yes.

All right. You talked about cycloastrogenol, which is in this one. This is a one of the first compounds that was shown to increase telomeres. This is one of the seven pillars of aging. If you read Superhuman, my big longevity book. And telomeres get shorter, like wicks in your cells. Every time they divide, they get shorter. If you can have longer telomeres, it's one of the things that says you might live longer. So there are studies showing this stuff works. I spent about $25,000 taking a high dose cycloestrogenone over three years, maybe eight, nine years ago.

Okay.

And that was a discounted price compared to what it would normally cost for the doses I was taking. I didn't really notice a difference. My telomeres are longer than normal, but not like knock on 12. Right. So this is a lot of money and a lot of pills, and it didn't work very well. What makes it work topically versus orally?

So if we look at the science behind telomeres, and you can talk to anybody that has worked on telomeres, or longevity protocols for that matter, they all will tell you one thing. The telomere lengthening only works if your oxygen stress levels are near zero, which is nobody. Which is nobody. And so combining them with the G serum, which is to reduce oxygen stress down, this would reduce it down like literally within minutes. And then you put this extra adrenal on top of it. There's a potential of having better results in a shorter time because you took for three years. What if I can do the same thing in less than six months for you?

And just by doing it topically?

Just by doing it topically, and literally fraction of the cost, Instead of paying 25,000 bucks, it literally costs you less than 5, 600 bucks.

Okay, I'm going to ask you an inconvenient question. Now, I've had a couple other guests on the show with really innovative skincare things that have entirely different pathways than glutathione and cycloestrogenol. Is there any harm of, say, taking a mitochondrial stimulant topical thing and putting that on and also doing this at the same time?

Like what kind of microchondra things like.

Urolithin A or things like anti aging peptides? You know, there's good clinical evidence for these things. Like I want everything. I want to have the skin of, you know, 20 year olds and I have really nice pliable skin. Like it? It's good. I just have a lot of it from having lost all this weight. And so I'm like, I kind of want to do everything, but I, I'm concerned. A, it's a lot of time and B, like if I put this on, am I canceling this out? Is there a lot of interactions or can I handle different aspects of skin aging? I think antioxidant reduction and using glutathione is foundational. So I would do that, but can I put on some other compound afterwards?

And yes, and so that's, that's what my research is right now, so to speak. So we are working on a few molecules right now. I was gung ho about four years ago about NAD being one of the molecules too, because when I use glutathione, it spares nad. So, hey, can I increase more nad? Can I get better results? Not so much. I'm okay, I'm okay. It's not earth shattering at this point.

It seems like NAD will get results for about a month or two. And after that, if you're not suppressing CD38, CD38 will eat all of the NAD you give it, which is a problem.

Yeah.

So do you know offhand, does glutathione reduce CD38 levels?

I have not measured those.

That would be very interesting to find.

That would be something for my researcher to work on it. We did measure the CD4, CD8 counts, the T cells and all those things in the lab and show marked improvement in the immune markers within three days. Only to do three days to reduce NK cell activities and T cell counts and all those things. It just shows that improving gluten levels so fast has a profound impact immediately. But then having it doing concurrently for a few months in a row, you can have really, really good outcomes data from there. So that's what we look at. CD38. Not yet.

Okay. You are very diligent in Your science and guys ro wellness a u r o wellness.com use code Dave10 and you get 10% off as a way of thanking you for listening to the show. All right, one more question. We know that one of the things that causes you to. To lose hair is excessive oxidative stress. Now, you don't have any hair.

No.

So can I take gluterol and just spray it on my scalp? Is it going to help my hair?

Okay. So I've been using glutathione in my patients for 15 years. Probably over 100,000 people that we have tried on. Not even one has come and told me that my hair has got thicker or better.

Okay. That would be. Probably not going to help you.

Not going to help you. So please, if you're using for hair loss, look at me. Right? If you.

Most honest answer ever.

Yeah. So yeah, don't use it for hair loss. I don't. So what that tells me is that we still have to dig into more detail as to what the cause of hair loss is.

It seems like there are. There's a DHT buildup in some people, but it's maybe not the primary cause. We also know oxidative stress can lead to reduction of mitochondrial function, but it seems like that's more of a peroxide and peroxy nitride effect. As far as I know, glutathione doesn't help with peroxy nitrate.

It will help them a little bit, but peroxy nitrites are mainly for getting your hair gray from dark. Right. So does it help with greenness? It will stop. Will stop it, but it will not improve it any better because it's already done. It's like. Seems like vitiligo, right, the skin disease, it will kind of stop on the progression. It's not going to do much more than that because it's not really a medicine for that one. But yeah, all these theories about hair loss is, I think we still have not figured out yet.

The good news is I know a couple people working on actually stem cells that are differentiated to become hair follicles. So they'll be able to within three years. If you want to go to one of the few countries that allows medical freedom, places like Costa Rica or uae, you'll be able to go there and instead of getting a hair transplant, they'll just put stem cells on your head that turn into hair follicles and you're go like the world is changing so fast.

It's so cool.

And maybe after that procedure, which is going to be inflammatory, you probably should put some glutathione on it.

Yeah, all procedures are inflammatory, so having glutathione on board is absolutely necessary.

It's super cool. Well, Nan, I appreciate you being on the Human Upgrade again. You are very, very focused on the science people listening. The way you're talking about bioreactors. I love being able to talk with a real scientist, not a marketer. It's clear you believe in what you're doing and, you know, you've done a lot of things that people don't know about on making. Making the world a better place. And I. I appreciate that as well.

Thank you.

And so I think you're one of the good guys. And if you're listening to this and saying, I have mold, I have metals, I'm tired all the time and I can't afford to get glutathione and all these other things, and you're saying, why, I want to buy a sauna and I want to do this. And, well, $2 versus 200 bucks. Raising levels in the cells more than an IV. This is one of those things that just radically lowered the cost of getting access to these molecules that are profound. Longevity molecules. And if you are still someone who says, I'll just have a couple drinks every night, or just one drink every night, you should be spraying this stuff religiously because alcohol makes you older, faster. It is not good for you. Yes, it's fun. I'm not saying I never drink. I might drink a couple times a year. Good sake is my favorite. If I do, I'm going to be kind of taking 20 sprays, right?

More than that.

Sometimes more than that. Okay, got it. All right, guys. Ro wellness a u r o wellness.com, code Dave 10. This is the real deal. I'll see you next time. See you next time on the Human Upgrade podcast.

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