Methylation & Detox: The Missing Link in Chronic Fatigue and Poor Immunity

Hi, good morning everyone. Thank you so much for joining. If you can just give me a minute, just a slight technical snag where I need to be the host. So appreciate your patience if you could just give me a minute while my tech team makes me the host of this.

Hello everybody.

Till the time Dr. Ritisha is coming, um, please share in the chat box from where have you joined and what, what do you do. Hi everybody, in the chat box please, from where have you joined and what do you do? Can you hear me? Great. Hema, welcome. Good to see you here. Gunjan from Nida, thanks for joining, Gunjan. Hi Madhu, happy to have you here, ji. Who else is there, guys? Dr. Vishnu, thank you for joining. Good to see you here, Dr. Vishnu. Yes, please, others also, please. Good morning, Dr. Vishnu. Great, thank you for being here. Malini from Gurgaon, thanks Malini. Monica from Bangalore, Ash from Goa, great. So I think Dr. Riti has sorted her technical glitch, but before that, anybody here who understands methylation and what is it that you want to take back with you after these next 30 minutes? In the chat box, please. Hi Rashmi, good to see you. Over to you, Dr. Ritisha. You are muted. Thank you. Ritisha, your voice is breaking.

So can you hear me better now?

Yes.

Am I Ma'am, can you hear me now?

Yes, loud and clear, and over to you.

Okay, so, um, thank you for attending. I appreciate that you've taken out the time and I mean, good to see a big number. Would appreciate if you all keep your videos on so that I know I'm not just talking to a wall. It'll help with the, with the participation and keeping me motivated as well.

Uh, in case Dr.

Rikisha, you have muted yourself. Just give Ritesh to 3 more minutes. Okay, by the time Ritesh is coming What is it that you want to go away with after this class today? Anything in particular? What is that one thing, if you understand in more detail, you would feel happy?

Methylation.

Thank you. I think methylation is such a topic that the more you read it the more confused you become, right, Dr. Vishnu?

Very true, very true.

Yeah, and at the same time, it is so powerful that mental health, energy, fatigue, detoxification— everything works around, um, you know, methylation. And, um, and we study it very early in our medical times But I think every time I see that graph again, I get one more click. So over to you, Ritisha. You are muted, and we are very excited to be learning from you something today.

Great, thank you.

You can share your screen.

Are you in Kobolona? You're in Kobolona. Hey, I'm really sorry everyone for all these technical challenges, but I hope I'm sorted now. And we can— okay, if I could just request the other participants to be on mute as well. Sorry, could I— could you please be on mute? Okay, thank you. Yes, uh, so as I mentioned about Dr. Preeti, um, she also holds a fellowship in functional medicine, um, and also has done a specialization in anti-aging. She's also a certified executive coach, uh, from, from Florida, and has been trained, um, by a Howard graduate, um, closely on that. Now this is image showing the basics, the fundamentals of functional medicine. As you can see, we look at it from a very holistic pattern. It's just not your basic symptoms. Now, how functional medicine differs from traditional medicine is that usually when you go to your physician, you talk about the symptoms that you're having, and then basis your symptoms is what your physician will normally treat you. However, functional medicine, we kind of work back, back ways. We take a very detailed history, you know, starting, starting from, from the bottom. So if you can see, uh, we're personalizing everything about you. So we need to know everything about your lifestyle, of who you are, your stress, your relationships, everything, what makes you tick. And basis that, we try to understand how is it that these other external factors are having an effect on your internal body. And basis that, we try to identify the root causes, and that's how we treat patients in functional medicine. Functional medicine is not alternative therapy. It's not about yoga and massages. Yes, that is a part of it, but functional medicine is proper medicine. We are very research-based, and we are a newer branch of medicine, so to speak, because we've implemented a lot of the newer research that comes in. Now, how many of you associate with this picture? Like, if— I mean, I would love to see if any hands— if you have woken up full of energy and you're right now probably at 50%. Does anyone want to have a show of hands? Okay, thanks, Gunjan. Anyone else? Yes, thanks, Babna. Okay, thanks, Deepa. Thanks, thanks, Moncia. Okay, more. I'm seeing more hands, so thank you. So guys, I mean, you have to be very honest here because like I said, functional medicine analyzes you as a person and, you know, your lifestyle and all the external factors. So yes, this is a lot of us, including me. I mean, there are days where I am just exhausted. So it's everyone, I would say, who goes through, or maybe I would say 90% of us who do go through fatigue. So despite this fatigue, I mean, are you getting enough sleep? Do you have brain fog? Are you always suffering from low energy, mood swings, but have not really found an exact reason? This could be because your biochem— your body chemistry is off. Now, when I talk about body chemistry, it's about all those small, you know, biochemical processes that happen in your body. So this is where, uh, we are also slightly different from a functional aspect, and we will talk about details. Okay, so like I said, if you are someone suffering from fatigue despite sleeping, you know, your 8 to 10 hours, you constantly have brain fog, low energy, mood swings, it is possible that something is off in your body chemistry. Could this be a toxin buildup? It definitely could be because we are exposed to so much toxins around us, like we have from the air we breathe, industrials, like the paint in our houses, even cosmetics for that matter have some amount of trace elements. So our body is constantly, constantly exposed to toxins everywhere. We try, you know, thinking that, okay, I'm in a very toxin-free environment, but that is not necessarily so. Like I said, even personal care products that you're using inside your house could be having some amount of toxins. Besides environmental toxins, even bacterial and viral loads are also considered as toxins. The air we breathe, obviously so much pollution. I mean, so many people have air purifiers. So yes, toxins are all around us. Our body in itself also has its own detox system. You know, for example, lungs. You know, we are taught in school that we breathe in oxygen and we breathe out carbon dioxide. So that is a kind of body doing its detox effect. Passing of urine, passing of stool, these are also other mechanisms of detox. Sweat, sweat is also detox. Now another, what we do as well as part of detoxification is regular exercise, eating a healthy diet, anything to improve your lymphatic drainage through, through massages. These are the things that we personally also do. To detoxify. However, sometimes we fail at it. I mean, I wouldn't really say we fail at it, but no matter how hard we try, there might be some challenges we're not aware of, and because of this, it leads to a poor detoxification, and this in turn leads to fatigue, inflammation, and hormone imbalance. So before I actually get into it, another question that I wanted How many of you have suddenly have like increase in weight gain, or, or are you exercising and you feel that, you know, you're not losing weight? Anyone want to share? Okay, so even weight gain is also something, um, that is a, um, that's caused by, by poor detoxification. Now let's come to the star of our show, which is the methylation connection. Now, with— now, what is methylation? Um, it's, it's become a pretty, a pretty common topic, uh, so to speak. I mean, if I, uh, if you even on, on, um, on social media and even on Instagram, uh, YouTube, uh, Shorts, I have seen people talking about methylation. I'm— in fact, when I was doing my research, I was surprised to see so much information is already there about methylation. So it's becoming a pretty common topic these days. So what methylation basically is, it's a, it's one of the very essential chemical biochemical processes that happen. It's actually the second most important. Your very first important biochemical process is actually oxidation and catabolism. That is the, you know, energy production is your very first and most critical biochemical process. Second is methylation. Now, what methylation basically does, it's in a very layman's term, it's kind of like an on-off switch. So we have a methyl group called a CH3. So it's a single carbon and 3 hydrogen molecules bind together. So it's called methyl group. And this methyl group is then added to, I mean, it attaches itself to, you know, your DNA or different protein blocks in your body. And once this methyl group is attached, it in turn leads to another essential process. So kind of like a domino effect, okay? And like I said, it's like an on-off process in very simple terms. And if methylation doesn't happen, it leads to detrimental issues that we will talk about later. So what does methylation help in? What are the processes that it switches on? It turns your food into energy. It helps to remove all the harmful toxins and chemicals in your body. It balances your mood because it helps to produce, um, your serotonins. And it keeps your DNA and cells healthy. Which again leads to slower aging. So if this process, the cycle, or the switch in itself is broken, everything slows down. So have any of you heard of MTHFR? It's a very long word— methyl— methylene tetrahydrofolate reductase. Has anyone ever come across this term? Okay. Uh, yes, uh, it's, it's not a common term that probably your physician would have talked to you about, uh, but it is actually one of the very, uh, important genes, um, that is relevant to our body. Okay, it is the most important gene that relies on, on methylation. Okay. Because this gene helps in the conversion of folic acid to methyltetrahydrofolate. Now, what this folic acid is, it's one of our B vitamins, which is very essential to initiate these processes that we talked about. So that it's basically converting an inactive form of folate or folic acid into a more active a more active state of it. Uh, and because— and if this methylation doesn't have— if, if the MTHFR gene is not there, your folic acid remains inactive, and this can disrupt a number of, of action which also feeds your nervous system. If your nervous system isn't supported, obviously this will lead to a lot of global consequences. And also, if you notice— I mean, if you realize um, like in a pregnant woman, if you see that the very first medication that she is given, she's given iron tablets and folic acid. And folic acid is given because it is detrimental to the healthy growth of a fetus. So if you can see, I mean, if you're giving folic acid, uh, at the time of pregnancy, you know, for the, for a, a good healthy child, it means it has a very important role in our body. So The active form of folic acid is what starts and creates a series of countless critical enzymatic reactions in our body. So here, this is just, uh, some of the biochemical, uh, stages that happen. One of the, um, Sorry, just— okay. Yeah, so one of the compounds that are created in this methylation cycle is called SAMe. Okay, and this SAMe is required to create CoQ10, carnitine, and creatinine. These are again some very common nutrients you would have seen in some of the supplements, especially cardiac patients these days. If you look at some of the, the medication that a cardiologist prescribes, it always has CoQ10. So CoQ10 is an, an antioxidant that is very, uh, commonly prescribed these days. Now, um, homocysteine is a byproduct of SAMe. If you have looked at your blood reports, especially recently, you would have seen that homocysteine is one of the, the lab markers, you know, for which you've seen in your report. And homocysteine is basically an inflammatory marker. What it means is that if your homocysteine levels are high, that means there is inflammation in your body. And one of the reasons why your homocysteine is high is because of a dysfunction in your MTFHR gene. So methylfolate, which is the active form of folate or folic acid, If it is not present because of a mutation in the MTFHR gene, it will lead to increased production of homocysteine. And because of this increased production of homocysteine, it will not be also excreted properly out of your body. This is just the biochemical process so that you know that, you know, this is all science-based, you know, uh, it's not, it's not, uh, just made up. So this is all factual science, um, that shows that, you know, and this is also telling you that, you know, we are actually looking at the root cause as to why, um, you have such issues. You know, if your folate is not here, if you see folate is one of the starting point of this methylation cycle it helps with your DNA synthesis, it helps with methylation of other proteins and DNA. And here you see other byproducts that come. So you have homocysteine, and if B6 is not there, then it is not able to convert homocysteine into cysteine, which is another compound that can be utilized by the body, and it is not harmful. So also you can see, you can see your B12, B6, B6. So vitamin B, your B vitamin groups are very essential for this process. So yeah, like I mentioned, what nutrients power the cycle? So we have your B2s, commonly known as your riboflavin. It activates folate, which I showed was the very first step in your methylation cycle. And it supports the MTFHR gene. Then you have your B3s, known as your niacin. It makes NAD for energy and detox. So you would have heard about NAD in your school time, in the chemistry classes. NAD is required for energy. B6 is known as pyridoxine. It helps to convert homocysteine into cysteine. Then you have B9, which is known as folate. Uh, folate again being one of the most critical, um, first steps of your methylation cycle. And then other essential cofactors are magnesium, zinc, choline, and methionine. So what breaks this methylation cycle? What are the causes that could slow down the process? One, as I've mentioned already, is the MTFHR gene mutation. Poor diet, so which means that, uh, you're not eating diet that is sufficient in your B vitamins. Stress, uh, we think it's not important, but it definitely is. Gut issues. Now, in gut issues, we talk about absorption, because a lot of times you might think that I'm eating healthy, but if your body is not able to absorb it, then there's no point in it at all. And obviously, which I've mentioned right at the start, are your environmental toxins. If you're wondering how toxins impact us, it's because there's something known as epigenetics. So what epigenetics is about is that these toxins alter the gene expression. In the sense, it does not alter the actual nature of your DNA, but it alters the gene expression, meaning how it will behave. So epigenetics is the effect of toxins and environmental factors on our, on our DNA. So which is by stress and, and toxins, these are equally, um, important because this does— research has shown that it does impact, um, our DNA. So coming to the MTFHR gene mutation, uh, the most common types There are two common types, which is your C677T and A1298C. It can reduce the methylation capacity by 70%. And obviously, like I mentioned, if this is not there, it leads to very high accumulation of homocysteine, poor detoxification, and mood issues. Mood issues is actually one of the most starting symptoms of gene mutation. Again, this mood issues is because there's a reduction in serotonin, dopamine, and norepinephrine. And because of a reduction in the methylation by 70%, this will lead to neural tube defects. Okay, this happens, uh, at the time of pregnancy, uh, clotting of blood, heart disease. If you have a very high level of homocysteine, you're at risk of, of a heart disease. It can lead to stroke and certain psychiatric disorders. You may need methylated B vitamins to bypass the defect because, again, as I've shown you in the, in the biochemistry, you know, our B12, the group of B vitamins, is what helps. What are the common symptoms of methylation? You have fatigue, brain fog, anxiety, mood swings, hormonal issues, infertility or miscarriage, poor detoxification, sensitivity to smells and chemicals. So if you're sensitive to smell, you know, you might think that, um, okay, this is something weird about me, but it's actually a sign of poor detoxification, skin issues, headaches, and even ADHD. So here we are talking going to talk about the supporters that, uh, make your methylation cycle more efficient. So vitamin B2, it plays a crucial role in energy production. Um, it acts as an antioxidant. It protects your cells from free radicals. Uh, it's also known to improve migraines, and, uh, B2 also helps, uh, to reduce the level of homocysteine A deficiency of riboflavin is actually quite rare because it's very commonly found in a lot of foods. So, uh, it's, it's not a very, uh, common case to see riboflavin deficiency. Um, and like I said, it's also available in dietary supplements. So sometimes dietary supplement is not necessarily taking, um, an actual supplement per se, but, uh, you find a lot of, uh, some of the like cereals and, um You know, it's written like fortified, like even for example, salt, you know, they said fortified with iodine. So it means that they have added extra nutritional supplement to the food item. Then your B3 is known as niacin. It is a vitamin that is made by the body itself. It works as a coenzyme. It helps to convert um, the food that you eat into energy. It helps to create cholesterol and fats. Uh, now you're saying it's creating cholesterol, fats— this is not bad. You— your body actually needs cholesterol and fats for a lot of its processes. So, um, it's a good thing that we have niacin in our body. It has to create and repair DNA and also exert its antioxidant effect. So because it creates cholesterol and fat, it actually helps to reduce your bad cholesterol and helps to increase your good cholesterol, which is your HDL. And it also is known to reduce the amount of triglyceride in your, in your blood. The most common deficiency, the disease that is caused by niacin deficiency is called pellagra. The, the symptoms of pellagra, first and foremost, actually inflamed skin. So you'll have a lot of rashes, itching. So inflamed skin is one of the first physical signs that you see, but also poor mental function and digestive problems. Then we come to vitamin B6, known as pyridoxine. It's responsible for breakdown of proteins, carbs, and fats. It assists with production of your red blood cells, supports immune system, brain health, and maintenance of nerves. Deficiency of B6 is usually— it doesn't happen independently. It usually happens, you know, I mean, like not seen alone. So a deficiency of vitamin B6 would probably be associated along with folic acid and B12 deficiency. Then folate, which is your B9. Folate is also known as folic acid. Both of them— folate is a more naturally occurring form in foods, and folic acid is what is found in supplements and fortified foods. One of the most essential nutrients, it helps in cell growth, DNA formation, and red blood cell production. Particularly important during periods of rapid growth. So like I said, pregnant women are given folic acid supplements because of this. Deficiency can lead to anemia, birth defects, and increased risk of heart disease. Symptoms include fatigue, weakness, shortness of breath, heart palpitations, and difficulty concentrating. And our last, vitamin B is B12, known as cobalamin. Excuse me. Vitamin B12 is a nutrient that your body does not make, so you need to take— make sure that you are having food sources that are very good. And actually, animal sources are a better source of B12 compared to plant-based. So if you're a vegetarian, you'll have to look for other options that have a good source of B12. This is also involved in your red blood cell formation, DNA synthesis, and nerve health. You would have seen, like, even again in your blood reports, B12 is the most common— I would say it's the only B12 that is actually tested for in your health packages. And Mainly because B12 needs to— the deficiency, the most common symptom is your nerve degeneration. Deficiency can be due to— main issue being that it's not being absorbed. So like I said, if you have gut issues, you will have a problem in absorbing B12 from foods. Lack of intrinsic factor due to pernicious anemia or the prolonged use of certain medications. So yes, some medicines are harmful. I mean, I wouldn't be— sorry, not harmful, but they do inhibit the absorption of B12 from foods. Like I mentioned, the deficiency or neurological changes is very rampant, palpitations and fatigue. Also, symptoms of B12 are not immediate. They take a very long time to manifest. So again, this is one of the reasons why we do a lot of early testing for for B12. So now that we know that your, your B vitamins are essential for, for methylation, and as you've seen, you know, from the symptoms, uh, most of it is very common. So we've talked about, um, fatigue, uh, brain fog, lack of energy, mood swings. So these are very common symptoms across the deficiency of the B vitamins. Hence, what is the answer? So a supplement, your B vitamin complex, but it has to be methylated. Now, why we talk about methyl— why does it have to be in a methylated form? All this while we've been talking about a methylation cycle. It's about converting folate into methyl tetrahydrofolate, which is a more active form. So your body needs a methylated version of folate because if that methyl is not there, if that CH3 group is not attached to folate, then everything is just useless, right? So, um, I, I'm, I'm a, uh, I'm an MBBS. Um, I used to practice allopathy medicine. I'm now, I'm a functional medicine practitioner, but Now I understand the difference. So in the past, I personally have recommended B complex to a lot of patients, and I see their vitamin B12 being low, but it takes a long time, you know, for these B12, B, B levels to recover. However, if you're giving your body the right, the right active form, then only it will— you're helping your body because you already have an issue, and having an inactive form is not going to help it. You know, so which is why it is very essential that you have the correct form of, of a B supplement, and that has to be methylated. I've also shown you an image of what a supplement looks like. Now see, in functional medicine we say read your labels. So here if you see, you have folate. Folate is in the methyltetrahydrofolate form. So this is the form that we One. Okay, so whenever you— the next time you take up any supplement, especially— so since we're talking about vitamin D right now, see what is written at the back of the supplement. Is, is methyl mentioned? If methyl is mentioned, then you know that this is right for you. So why, like I mentioned, why, why do we need, uh, the methylated ones? Because it is the active form. What are other things that you should see, um, on your label is that it will also mention other, um, your B vitamins. So you'll have B1, B2, B3, B5. So we'll mention other groups of B vitamins. It'll also mention other ingredients like choline inositol, uh, then trimethylglycine, because these are additives, uh, it helps to increase the functioning, um, of, um, of your B vitamins. And then also, it will also mention that it is non-GMO and gluten-free. Um, this is also very essential because, uh, obviously it's not genetically modified, and gluten-free because, uh, gluten also tends to interfere with some of these, uh, biochemical processes. Uh, so which is why, uh, we— the label should read gluten-free. And with that, I have come to the end of, um, my presentation. Uh, this is just, um, a slide showing what are the services that we have, uh, at, um, at our clinic. So like I mentioned, uh, while main— essentially, yes, uh, patients come here, we do a consultation, um, it is a very, uh, intensive consultation. We don't just spend 15 minutes We spend a good hour or more, you know, understanding everything, you know, about what, what ails you. And along with that, we also provide other services as well. Your hydrafacials, your PRP fillers, Botox. This obviously comes under derma, but specifically to our functional, we have gut health healing, we have colon hydrotherapy. IV nutritional therapy, ozone therapy, Thyroflex, and EECP. EECP is for your blood, blood, any issues in your, in your blood. And then we have an oligoscan. Oligoscan is, is a very important tool because it will help you to identify if your, if your body has toxin. So I would say that along with all your, your annual health checkups, it's, it's becoming very important to know, uh, how much heavy toxic heavy metals you have in your body. So because with this you'll also get the right treatment, you know. So, um, please, um, if you are someone that resonates with what I have spoken about, uh, do come and look for a functional medicine practitioner because like I said, we work from the ground up. We look at root causes, uh, and help you heal better. Uh, now I shall open it for questions. Um, I have Dr. Preeti with us who will also help to, um, answer whatever queries we have. Ma'am, over to you.

Thank you, Dr. Ritisha. And for the first time, it was a good discussion. Great. Uh, so you can stop the screen share. And guys, I must tell you that I told Ritisha that I want her to speak on methylation just Monday evening, right? And methylation is something, as I was telling in the beginning to Dr. Vishnu, that you, you don't know enough, right? So Ritesha, you can stop screen share.

Yes, ma'am, I'm done.

Yes, any questions if anybody has? I have shared some sources of B vitamins in the chat box. I feel bare minimum, if any patient comes to us, these sources we should give them. In my practice, I have seen infertility cases being helped only by making sure that we— I'm using methylated B vitamins and checking their methylation. Two people with depression and ADHD getting very good results. And 2 days back, I was speaking to one of the psychiatrists who works in integrative space, and I asked her, uh, what is your USP, or what have you learned, you know, what works for you best for your patients? You know, her answer was, Preeti, I don't have to do chelation on all because I work so beautifully on methylation and it is giving me very good results. And I definitely agree with her. Right, so, um, keep this chart or the flow in mind. Have a printout kept on your OPD table, and this is where you must start. Yes, Deepa, very good question. So, you know, where does B12 come from? Anybody here who can tell me? What are the sources of B12? One is food. Any other source from where we can get B12? Anybody, please? Gut bacteria. So basically there are two things which we have to make sure that, you know, they happen right for us to have good B12. One is of course your diet, but second is your gut health. Uh, Dr. Risha, please copy paste and send what I've sent in sources to everybody here, right? Risha, from the chat box, if you can copy and send the, uh, sources to everybody. So, um, one, without doing any gut health test You can know whether the gut microbiome is good or not for your patient. Simple clue is add B12-rich foods and check B12 after 3 months. If the B12 has not increased, means the gut microbiome is not good. Second, I have patients where I give them B12 and still their B12 does not increase. Too much. Again, gut microbiome. So guys, there is a shortcut for a short time. So you can give supplements for short time, but you have to make sure that you work on the gut health. You have good pre and probiotic mixes, and they are in a combination where short-chain fatty acids are made in the colon. Because all of that will help the body and these bacteria produce B12s. And that's what we want, because another thing we want to remember is that these are all water-soluble vitamins, so they cannot be stored too much. So fat-soluble can be really stored in the body, but water-soluble can't be. So everyday in diet you need to have a bit of it, and the gut health has to be extremely good. Uh, so this question, um, Deepa had asked me. So Deepa, you need to work on your gut health. If you can let me know what is your monocyte, eosinophil, and basophil, um, total, that will give us an idea. If you can let me know your lymphocyte-neutrophil ratio or the numbers, that will give us an idea. But I can tell you with 100% confidence that the gut microbiome needs work. Shedra, we will share this. So somebody, Emma, has written spirulina, but what is the question? I could not get. So Monica, what means when body is not absorbing? What it means is that when you are taking cyanocobalamin form of B12 or when you are taking non-methylated form of B12, you increase one step in the process where it becomes effective. Now that step needs MTHFR gene to be active. With that MTHFR gene, it gets converted to methylcobalamin, and then it works what it needs to work in your body. Now the bad or the sorry state today is that about 40 to 60% of people today, their MTHFR gene is not working actively. I do genetic test for me, myself, and for my patients, and I see MTHFR gene is almost not actively working in 50% of the cases. And that's the reason you want that you do a lot of methylated stuff. Yes, it is expensive. But it is worth the money because if you're taking the other one and if your MTHFR gene is not working right, then what will happen? Your homocysteine will increase, body will not detoxify, you will have anxiety, ADHD, ADD, OCD, all of those things. So it doesn't help you at all. Yes, and if some point of time your patient can afford it, you can afford it, then doing an MTHFR gene is a Great idea. Means there are few tests in genetic testing which I love. First one is MTHFR, second is vitamin D sensitivity. I have people who I give 10,000 IU vitamin D every day, but their vitamin D is 12 in the beginning and 15 after 3 months. So you know that vitamin D sensitivity is not there, but when you check it, then the patient agrees to take high doses for a longer time. Otherwise, they keep questioning and thinking maybe your supplement is not of good quality, right? So simple things, and they can make a huge change. What is a good brand of B12? I generally use either international brands or Total, uh, B Complex from FMD. That is giving me good results. In allopathy also, you will find methylated versions. If you go on 1mg, you will see that you have good methylated versions. Just remember to read. Like Dr. Ritisha said, if it's a cyanocobalamin, doesn't help. If it is methylcobalamin, great job. If it's methylated B6, perfect. So just read the label and you will know what is needed. Right, and we will have— we will share the link with all of you of the B complex I use, uh, for you to know all the details there, right? Any other questions? One. And second, any other topic you will want us to cover? I have decided that my team members will take 20-30 minute webinar 2 to 3 times a week so that we can spread information and knowledge, whatever we know. Choose the topics you want and share with us the topics you want more information on, and we will be happy to, you know, do the next webinar on that topic. Thyroid, good, Hema. So this Sunday I am doing a webinar on thyroid, especially autoimmune thyroid. Hema, you could have asked for anything else too, right? So please join us. I will let you know the time, and, um, we will talk about thyroid and autoimmune thyroid in detail. Yes, Asidar, we will take infrared sauna in the coming times. We are going to take a session on colon hydrotherapy on Friday. Anybody here who has not done colon hydrotherapy must attend so that you can do it for yourself. I, coming from allopathic background, never believed in enemas and colon hydrotherapy and stuff like that. But now I am telling you, I love it because of the type of result it gives me. Gunjan, next time I will do it on that. But keep sharing your topics. You have my office numbers also so that we can plan. I will continue teaching till the time you are ready to learn. Okay, bye-bye everybody and have a great day. Thank you.

Thank you, everyone.