Histamine, Mold, & Menopause: Why Your Symptoms Suddenly Change

14 Oct 2026 · 47 min
46:44

In this Menopause Mastery episode Dr. Betty Murray interviews functional nutrition practitioner Marika Sterng, creator of the SENSE framework, to explore why many women experience a sudden onset of allergy‑like, neurological, and digestive symptoms during perimenopause and menopause. They explain how fluctuating estrogen and progesterone remove natural buffers, allowing histamine and mast‑cell activation to surge. Environmental factors—especially hidden mold and mycotoxin exposure—add to the histamine load, while genetic variations in enzymes that break down histamine (DAO, HNMT) and detoxify toxins (GSTM, GSTT1, COMT) determine individual susceptibility. The conversation covers how conventional medicine often misses this multi‑factor picture, and they outline a diagnostic hierarchy (comprehensive blood work, organic acid testing, gut microbiome panels, DUTCH hormone testing, and targeted genetic panels). Practical management strategies are discussed: low‑histamine diet, mast‑cell stabilizers (quercetin, luteolin, vitamin C), Epsom‑salt foot soaks, gentle detox methods (castor‑oil packs, infrared sauna, lymphatic drainage), and careful, individualized hormone replacement (progesterone as a natural antihistamine, micro‑dosed estradiol). They also stress the importance of lifestyle detective work—food and symptom journaling, stress reduction, dental and trigeminal nerve considerations—and offer a free 7‑day Calm Energy Reset guide that provides daily, low‑effort actions to calm the nervous system and build a personal symptom‑management toolbox.

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