Dr. Betty MurrayHelping Women Navigate Menopause | Speaker, Author, and Advocate for Women's Health Over 40

Obesity Is More Than Calories In, Calories Out

3 Aug 2026 · 1 min

Watch on YouTube

0:44

In this candid monologue, Dr. Betty Murray argues that obesity should be classified as a disease rather than a simple behavioral issue. She emphasizes recent scientific insights into brain‑mediated mechanisms—particularly the roles of GLP‑1, GIP, and glucagon pathways—that underlie weight regulation and are targeted by modern pharmacotherapies. Dr. Murray sharply criticizes the prevailing "calories in, calories out" narrative, using a provocative analogy to chemical castration to illustrate how hormonal changes can dramatically affect metabolism, especially in women. Her tone is confrontational and impassioned, underscoring the need to recognize obesity’s complex physiological basis.

Chapters

We're still calling obesity a behavioral problem and a follow-through problem, which makes me crazy. It is a disease state because we now understand, especially with the GLPs, GIPs, glucagon, all of that, that there's mechanistic things going on in the brain, which is where those drugs primarily act, that make it very difficult. And I get super pissed off at the Chad, you know, influencer gym guy who's 27 that says it's just as simple as calories in, calories out. And I was like, okay, let me remove your testicles. Right. Well, we'll castrate you and you tell me how well that works, sweet pea. Right. Because the reality is, is women go through chemical castration that is equal to castration for men. And if you don't think that there's a metabolic effect of that, we already know the difference.