Dr. Betty Murray explores how genetics shapes hormone biology during perimenopause, examining production, activation, receptor interaction, metabolism, and elimination. She connects hormonal shifts to changes in thyroid function, mitochondrial efficiency, and detoxification capacity, showing why this transition requires asking more specific questions about how your body actually works.
I think that one of the things genetics does is to help us ask better questions. How are hormones being produced and activated? Can they communicate with the cells? You know, what's, what's the receptor like? Can they be metabolized and eliminated efficiently? What are they binding to and how strongly? And then there's the rest of the environment that this is happening in. And I think that perimenopause and menopause time of life is when a lot of other things shift. Thyroid can shift. Metabolism can shift, not only because of the hormones, but just because sometimes that can happen. For people where they're aging a little bit, there, maybe their mitochondria has gotten to a point where it's a little tired and the detoxing that they've been doing up until this point that may not be as strong as they'd like it to be, it catches up with them. Right. And so it's sort of this sweet, special spot that we can get ourselves into where sorting all of that out becomes a lot easier with more information and different kinds of questions.
