Having testosterone circulating isn't enough if it can't bind to your androgen receptors. Sex hormone-binding globulin (SHBG) traps hormones so they can't reach muscle tissue, like keeping them stuck on a roller coaster instead of letting them work.
If the androgens are floating around, but they're not really binding well, if that sensitivity isn't there, people may have a harder time putting on muscle. And then you have to also look at SHBG, you know, and then how tightly are these things bound? How much is actually available for tissue use versus being trapped by this binding globulin and just hanging out like a little bit like they're on a roller coaster that they can't get off of and they're not— Right. It's not making it to where it's going to be as useful as you might want it
