Dr. Betty Murray explains that GLP-1 drugs like semaglutide don't automatically cause muscle loss. A meta-analysis found about 25% of weight loss is lean muscle, but it depends on protein intake, resistance training, dose, and hormone therapy.
And I hear this a lot from women. They'll be on GLPs and their— the first question is like, am I going to lose muscle with fat? And the answer on is, is really it depends. It depends how much you're taking these medications, whether you're getting enough protein and lifting weights, and also what kind of hormone therapy you're using. So a recent meta-analysis that looked at body composition changes with different GLP drugs So they looked at both Wegovy or, or tirzepatide, and they also looked at semaglutide. And here's what they saw. Yes, you will lose some lean muscle mass. On average, about 25% of the total loss would be muscle mass, but the degree varies.
