How much more concentrated are healing materials in bone marrow aspirate compared to whole blood?

Dr. Joshua John-Ram SchacterDr. Joshua Schacter, DO FAAOS, is America’s Holistic Orthopedic Surgeon, with nearly two decades of surgical expertise.

60x More Healing Power

22 Jul 2025 · 1 min

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Dr. Joshua John-Ram Schacter explains that bone marrow aspirate contains roughly 60 times more mesenchymal stem cells and healing proteins (growth factors, interleukins) than whole blood, making it a powerful orthobiologics treatment. He describes processing (spinning down bone marrow to isolate desired cells) and tuning formulations for specific tissues (e.g., tendon vs intra-articular joint) to match patient needs.

Questions this video answers

About 60 times more.

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There's 60 times more of that in bone marrow. So bone marrow aspirate is our most powerful orthobiologics treatment. Mesenchymal stem cells also have about 60 times more of those healthy materials that we need to heal your injury. So as far as human growth factor and interleukins and all of these proteins and substances that we need to get tissue to heal and inflammation to lessen, there's 60 times more of that in bone marrow. So bone marrow aspirate is our most powerful orthobiologics treatment. What we do is basically we take the BL, or bone marrow, just like we did with your whole blood, and we spin it down and we isolate those cells that we want, and we can tune that concentration to actually the type of tissue that we want to treat. So that if we want to treat a tendon, we use a certain type of formulation of the stem cell or platelet that if we want to treat inside a joint, we use another type of formulation. So we can actually customize that to the location and to the patient's needs.