Dr. Joshua John-Ram SchacterDr. Joshua Schacter, DO FAAOS, is America’s Holistic Orthopedic Surgeon, with nearly two decades of surgical expertise.

Overlooked Hormone for Women’s Health

22 Sept 2025 · 1 min

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Transcript excerpt from Dr. Joshua John-Ram Schacter arguing that naturally occurring estrogens (notably estradiol and estriol) are powerful and underused in women's health. He states estradiol can be safe and effective in women with breast cancer—particularly when combined with progesterone—and asserts estriol is non-proliferative and very safe, including for receptor-positive breast cancer survivors. The speaker criticizes over-reliance on isolated, non-significant study results.

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And this is a powerful hormones that occur naturally that we should be using.
There could legitimately be some concern about estradiol use in women with breast cancer, although to be honest, the studies are showing that it's safe and effective, especially if we have progesterone on board. But estriol is non proliferative. It's a very safe estrogen to use in women, even with women with a history of receptor positive breast cancers, because it's not proliferative. So there's options for everyone. And this is a powerful hormones that occur naturally that we should be using and be thinking about much more critically than. Oh, this one study showed a not statistically significant. I mean, it was just a travesty that what we've done.