Dr Laszlo Boros on Deuterium Depletion for Optimal Health

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Hey guys. Cribbin Govender from the Gut Health Gurus podcast. I've got a background in food science. My colleague James Shadorak, who's all things psychology, is unfortunately not able to join us today. He's got another appointment. But I've got an amazing guest for you today. It is some. If you recall, I, I did interview Dr. Jack Cruz a couple of weeks ago and today I've got someone who I equally follow very closely and all his work, especially around deuterium. And I have the pleasure of introducing Dr. Laszlo Borosh. Dr. Laszlo, welcome to the show.

Thank you very much for inviting me.

It's an honor.

And typically when we start our shows, I like to set the scene for our audience and to introduce our guests. And what better way to introduce a guest than from the horse's mouth. So who is Dr. Laszlo Boros?

So I do teach biochemistry at UCLA and this is the University of California, Los Angeles. And I'm a physician. I'm a doctor by training. I got my medical diploma in 1987 from Szeged, Hungary. I grew up in a smaller town in Hungary and then I went to practice medicine for a short time. Then I left for Germany and then to the United States and I was appointed in 1998 as one of the faculty members of the University of California. And I've been working for the Department of Pediatrics. But my work was mostly research related and studying metabolism using glucose molecules that actually have a special tag on it. We call them 13C tagged glucose. And we follow and I followed the fate of glucose in many disease scenarios.

In many disease processes.

And then around 2002 I came across with the team working with Dr. Gabor Shomyai who is my dear colleague from Hungary. And we have worked on various clinical applications of dute research. And then now we are delivering deuterium physiology or deuterium biochemistry as part of our education process at ucla.

And we also have a clinic where.

We teach how to practice deuterium biochemistry or deuterium awareness for your health in.

Los Angeles, in Brentwood we have a.

Clinic called DD Centers and so that we are getting into the clinical or.

The health applications of the topic.

Sure. And look I think it's a good opportunity now to just take a step back and define to our audience, who are very much a lay audience, but some of these terminologies that you introduced onto the podcast. So the first thing is, how about we define deuterium, which is, I think it is a hot topic. It's going to be even more prominent in the coming years. I think we're very much at that early adopter stage with people learning about deuterium. So what is the lay, I guess, explanation of deuterium?

Yes. So in very, very lay terms, deuterium is like a heavy cricket ball or a heavy football that destroys the game, practically.

And this is what deuterium does in.

Our cells when it gets into proteins.

And spinning proteins, working proteins, and particular.

Parts of mitochondria, for example, these nanomotors that produce ATP. By definition, it's a heavy isotope of hydrogen. It has a proton and a neutron in its nucleus, while hydrogen only has one proton. And this extra neutron makes deuterium twice as heavy. And as in any biological process, the transfer of atoms or transfer of energy in the form of hydrogen slows down. Then it becomes a deuterium. And that would actually devastate some of.

Our basic fundamental cellular functions.

And that's, in lay terms, that's probably.

How I could summarize the best what deuterium is.

Sure. So it's an isotope or a form of hydrogen. It's heavier than typical hydrogen and it can interfere with the biological processes within the body.

Indeed. And it's twice as heavy. So it's significantly heavy, heavier than hydrogen. And this, this is why it makes it such a bad heavy isotope, because there is no other atom or other biological constituent or other biological component in the atomic scale that has such a dramatic 100% increase or twice as heavy characteristics when it comes to biochemistry and physiology. For example, carbon, which has 12 particles in the nuclei, it also has a stabilized dope, which we call 13C, but it's only some 10% heavier.

Some are over 10, you know, close.

To 10% heavier than its 12C counterpart. So deuterium is bad because it's much heavier than its isotope counterpart. Yet it would participate, or try to.

Participate in every chemical reaction that hydrogen would.

So it's really a large increase in isotope effects.

And this is why deuterium has such obvious and very prominent biological and heart related devastating effects.

So what are some of these devastating effects that having excess deuterium in the body can elicit?

So the most difficult part, where deuterium can be processed is the mitochondria. Mitochondria are little cell organelle that produce water and energy from the oxygen of.

Air and from the hydrogen of food.

That we burn and oxidize in our cells. As we know, the result of this.

Is carbon dioxide, which we breathe out.

And also water, which we don't see much of it because it's recycled in.

A biochemical chain of reactions called Krebs Sanduity cycle.

But truly, hydrogen is very active in mitochondria. And more importantly, it actually drives or powers protein nanomotors, which produce ATP or.

Energy for our cells.

And these nanomotors are spinning at high velocity.

About 9,000 at maximum speed, about 9,000 rotations per minute. And at twice as heavy hydrogen isotope. You can imagine what it does to a very delicate protein system moving at that speed.

It makes it unbalanced, it starts wobbling.

And after all, it breaks.

So deuterium compromises our.

Mitochondrial energy production significantly. And it also slows down many other.

Processes in cells that relate to biochemistry. But it also.

Alters the structure of proteins and also the structure of DNA.

Because hydrogen bonds are very important in the holding together two helices of DNA.

And when these helices are bound by.

Deuterium, DNA repair enzymes can go through. It's like when you like mowing your lawn and there is a big chunk.

Of grass somewhere or there's some kind.

Of a physical barrier, then you have to kind of go around. So deuterium physically damages cellular components that.

Are necessary for energy production and also for for healthy functions. And for that reason, mitochondria is the prime and life.

And peroxisomes, which also a place in.

Our cells or cell organelle that produces.

Water from dissolved oxygen and oxidizing fat or burning fat. Those are cell organelles that are very sensitive structurally and functionally to the effects.

Of dt.

Peroxisomes are those akin to mitochondria. So small little organelles inside the cell?

Yeah. So mitochondria uses elementary oxygen, or just oxygen carried by hemoglobin. It's a chemically very active oxygen because it is looking for a kind of.

A partner or counterpart.

And deuterium and oxygen react very quickly, very fast. You probably remember from school, the exploding.

Gas oxygen and hydrogen mixture makes water very quickly and practically. The reaction is so quick that it.

Sounds like an explosion. And that's what happens in the mitochondria in a very controlled fashion, obviously. And peroxisome, on the other hand, they use molecular oxygen, which is O2, which is in air it does not require hemoglobin for carrying, for that matter, and not necessarily for that reason, peroxisome can use this molecular oxygen and hydrogen from fat mostly to produce peroxide. Hydrogen peroxide first, which is very rapidly.

Very quickly broken down into metabolic water.

Or water in our cells by the enzyme called catalase. And this is the enzyme, for example.

Which melatonin in mitochondria and also in peroxis on would activate.

So it seems that after all, it's all about deuterium and hydrogen capturing by.

Our oxygen in either form, molecular or elementary form. Yet both organelles deliver metabolic water which will have certain biochemical roles, very fundamental biochemical roles. For example, running the TCA cycle through recycling this water, or even becoming part of DNA by various, for example, gluconeogenesis.

Or pentose or 5 carbon sugar synthesis.

And it seems that they are all connected, they are all linked and they all originate from this water producing water production process in mitochondria and peroxis.

So to give the audience an indication of what, what quantity of water as a percentage is produced by peroxisomes and mitochondria?

Yes, so this is actually a very dramatic and large number in the sense that actually we produce our mitochondria and average human being produces about 7,200 liters of metabolic water a day, which is immediately recycled. And this is equivalent with the volume.

Of blood we circulate.

So it's not that surprising if you work with a physiologist or cardiologist just.

To see how much work you're doing, your heart performs as far as circulating.

Blood through your body, it's practically 7.2 cubic meter water getting produced and recycled.

In the form of protons each day.

An average human being. And if you look at an average lifespan, it's about 700, some around 700,000.

Cubic meter of water, which, for example, it's almost like a river flow, meaning.

That it's very significant amount of protons.

And water that we produce and recycle.

And this is just to run the system. It does not mean that it's net production.

It means that it's recycling the same.

Protons and with new oxygen and new carbons.

But it's, it's practically just a more like your car's, you know, cooling water.

Practically just recycled so many times through.

The engine and not necessarily a huge.

Volume yet because of its flux, because.

Of its recycling, because of its chemical activity, by the end of the day you circulate about 7 to 200 liters of this metabolic water on an average day with like moderate activities.

That is a staggering number of the sheer amount of water per day. I'm absolutely stunned.

Well, and you recycle it. And you know, if you look in your physiology book, there are other like shocking numbers. Like for example, your kidney produces about 800 liters of primary filtrate a day.

Which are recycled back into your circulation. Your heart pumps about 70200 liters of.

Blood throughout your body a day.

And indeed your mitochondria produce and recycle about the same amount, 7,200 liters of.

Water which has to be nutrient free to function properly. So it cannot have this semi heavy.

Or heavy water that we know from.

Atomic like physics in the sense that, you know, heavy water is so different in its physical characteristics that they use.

Heavy water to control atomic reactions in atomic power plants.

So it is a very fundamental and a very critical knowledge, but it's never.

Been applied to medicine until Dr. Gabo Somniai started working on some cancer models and treatments with depleted water. And sure enough, the observed effects were quite dramatic in cell culture and also in humans as far as their well being is once their deuterium level is controlled and brought down to the physiological level.

Absolutely. Now let's set the, I guess the level of deuterium that's normal versus something that's elevated from an environmental perspective. If we take tap water from Hungary for instance, what's a typical number in PPM that it should be?

So we measure deuterium by parts per million. And that's just a very simple number. It would tell you how many deuterium.

There is in and amongst a million hydrogen atoms.

In Budapest, drinking water has about hundred, somewhere around, somewhere around 146, 150 parts per million in drinking water. And this is very typical of like a middle European city. Usually coastlines have a little bit higher deuterium content because the team comes from the ocean after all, in the form of rains and vapors. Because the oceans are the largest bodies.

Of water in our planet and contain.

The most and the highest concentration of deuterium in water or open water surfaces. And because of temperatures, this evaporation and.

Evaporation of deuterium from oceanic water that after in the formal rain becomes part of crop and part of the vegetation.

Has shown certain kinetics and certain patterns.

Based on temperature, wind direction, speed and so on.

So it's this physical kind of fractionation or discrimination of deuterium because it's heavyweight depend on physical processes. Yet my logical Systems try to filter it completely out using these nanomotors, these protein spinning proteins that I mentioned a few minutes ago. And after all, when you look at ancient times and probably this is, I should answer your question. Back in the paleolithic time where actually humans and all like warm blooded species adopted to the environment. Like if we look back 15 to 20,000 years ago, deuterium was in vapor.

By 1015 ppm lower.

So meaning that if you drank water from a river 15,000 20,000 years ago.

Instead of 150ppm, it only had maybe 140 or 135 ppm deuterium.

And that's what we consider as drinking deuterium from external extracellular water sources, external.

Water, then it should be in that range below 130ppm.

We think that probably going back to.

Like 100,000 years when most of the warm blooded species have evolved in or have adopted to the environment, that's probably in the range of 120 ppm.

And that's what we consider biologically relevant. And this is why we believe that.

Depleting deuterium back to those levels benefit after all human health.

And to that matter of our warm water species. And again, it doesn't seem like a big difference. But because of the velocity and because of the transfer of protons in our system, this small difference between goes very far as how often proteins and DNA.

Needs to be repaired or deuterium needs to be removed from our system simply because of the kinetics of protons and deuterium in biological processes.

And the burning question I have is why has the deuterium level increased from those Paleolithic times to the modern era, it's by temperature.

So if you, yeah, so if you warm up the ocean water, just like you know, from ice ages, if you consider, well it's, it's very kind of easy for you guys because actually these studies were done in New Zealand. So physicists, they captured volcanic ash 15,000 years ago that was actually part of a volcanic eruption. And because New Zealand is a relatively small island, it's always covered by oceanic vapor. And when this ash, this explosion captured.

The oceanic water vapor and they measured deuterium contents, they were actually 1015 ppm lower.

So we know that these are actually, this is hardcore data in the sense that we, you know, we do publish, I publish about 100 papers in medical.

Literature, pre review papers in the medical.

Research and we also look at peer reviewed papers when we interpret deuterium related findings. And this is just like part of It. So the measurements, it's not a guessing game. The measurements show that ancient times or Paleolithic times, lutein was significantly lower in the environment.

And the result of that is because.

Of the lower oceanic temperatures once we went through geographical and also environmental changes because of the sun's earth distance and activities and the sun's activity.

And there's a climate change, which we believe is part of our. Mostly it's part of our.

You know, relationship with the sun. Deuteum may alternate from time to time based on oceanic temperatures.

And we believe that we would be better off if, like in ancient times, deuteume would be lower in the environment.

And I'm considering some industrial processes that definitely enrich deuteum in food products.

And we believe that these are also part of epidemiological scale of human diseases like diabetes, cancer, obesity, and some degenerative diseases. We believe that the team has a big role in these.

Absolutely. And I think that's a perfect segue. So if we summarize that the environmental conditions, things like climate change, warming of the oceans, have resulted in a level now that's higher than our ancestors would have been exposed to. Now, if we segue onto the food products, are you able to give us a bit of, I guess, advice on what foods are higher in deuterium and which ones could perhaps be lower?

Yes, indeed. And this is again a very interesting topic because it seems like nature figured it out, because in nature or. Okay, so there are two basic type of food or substrates that we burn.

Or oxidize in our mitochondria.

One is called a carbohydrate, which, as its name says, it has carbons dissolved in water. Water exists in hydrogen and hydroxyl groups, or OH groups. And this is.

But, for example, glucose is.

It has six carbons and 12 hydrogen, six oxygen.

So it's practically, you know, six carbons dissolved in six water molecules in a chemical form, meaning that the hydrogens and the hydroxy groups are attached to carbons.

And this is typically a carbohydrate. On the other hand, fat is more of a hydrocarbon, meaning that there is no water in it.

It's just only carbons and hydrogen.

And those are the best source of hydrogen, simply because fat or these hydrocarbons can only produce from citric acid, which.

Is part of mitochondrial metabolism.

So because mitochondria can deplete deuterium by.

Filtering it out using these protein nanomotors.

Biological systems produce their own fat from one of the metabolites that can only.

Be synthesized in Mitochondria called citrate. And the enzyme citrate synthase is a mitochondrial bound enzyme.

So there's no really other way of producing fat.

In the most robust pathways de novo from carbon and hydrogen than using mitochondrial deuterium depletion.

For that reason natural fat, grass fed animals fat is low in deuterium. Carbohydrates proteins depend on various other biochemical reactions, but those are usually high in deuterium. So carbohydrate diet may contain about 150, 140, 150, maybe the higher end of 140s ppm. Yet a natural ketogenic diet would only contain like 115 or 110 parts per.

Million of hydrogen deuterium.

I'm sorry, so that for deuterium burning, making metabolic water from fat in mitochondria is a lot more efficient and it's.

A lot more, and it's a lot more beneficial for our cells because it's low in deuterium and it gives you.

The highest rate of carbon to hydrogen.

Which powers our ATP synthase nanomotors, the most efficiently in molar turnarounds of the tco, TC or krabsandury cycle.

And this is what we call a.

Ketogenic diet or natural ketogenic diet. When you consume mostly fast and mostly fat and you kind of use the benefits of these very basic fundamental biological biochemical principles.

Sure. So I'm hearing ketogenic is perhaps a better strategy in terms of deuterium depletion than say maybe a diet that's higher in carbohydrates. How about fruits?

Again, let me add just one sentence here.

It has to be grass fed fat or natural.

Yep, sure, like naturally produced fat. And the reason for that is it's very important that the deuterium discrimination process starts in grass. So photosynthesis, because the photons or the.

Electromagnetic resonance that is carried in light.

Especially in red light, cannot break the oxygen deuterium bond. Therefore, photosynthesis discriminates against deuterium, because as we know, photosynthesis is practically breaking water.

From the ground that is soaked up by the tree leaves, by the tree.

And the tree leaves break this hydrogen.

And oxygen bond in water and the hydrogen will be attached to carbon dioxide and oxygen is released. And this is why the trees produce oxygen and use carbon dioxide.

So actually the circle of life starts with this very robust deuterium discrimination process in plants and animal fat that we.

Burn back into metamorphic water after we ate them with the use of oxygen. Again, this is Why I was saying this is like a circle, biochemical circle, magical circle.

So that's practically the best way of.

Producing raw deuterium water that is produced or discriminated against or the heavy water is discriminated against light water in plants.

And because, and this would best way.

This was the best way to answer.

A question because fruits, on the other.

Hand, are synthesized or produced by trees and plants using other biochemical reactions. They mostly use glucose or sugars to kind of wrap these very important like.

Seed material of the trees that as for their propagation or propagating the species or kind of establishing new faunas through the seeds. That's practically carried in the valley of.

Animals after eating the, the fruit.

And it has to be high deuterium. So it's not going to be absorbed, it's going to be filtered out by.

The gut flora or the gut bacteria.

And with that the animals would have more like a diarrhea.

And after that they would actually spread the seeds.

And plants purposely produce high deuterium fruits simply to spread their seeds because hydrothereum sugars, hydrogen food or hydrogen content proteins.

Are not very efficiently absorbed.

Into our circulation simply because bacterial gut flora and.

Also because of the transport processes are affected by deuterium. It seems that high deuterium sugars, they like to stay in the, in the bowels. And after all, deuterium munch on them.

And for that reason fruits and high.

Fructose, which is fruit sugar, high fructose nutrients in that form, like high fructose corn syrup and so on, are not very desirable for human consumption, we believe.

Sure. And this is the Gut Health Gurus podcast. So I wouldn't be doing the podcast justice if I didn't go back to that, that exploration of the gut bacteria. Now, what does, what, what's the effect of high deuterium levels or deuterium levels in general on, on your gut microbiome?

Yeah. So. And that goes back again to a very fundamental biological principle called the prokaryotes. Those are bacteria. Those are actually life forms, usually single life forms, which cannot control their deuterium content. Or actually they retain deuterium by spinning these protein nanomodels to the opposite direction. And actually that was the first paper in 1988 published in Nature by scientists from Italy. They showed that in bacteria, in yeast, to be more precise, these nanomotors spin in a direction that retains deuterium for these yeast cells.

And as a result of that, their.

DNA is constantly contaminated with deuterium.

And, and for that reason, they grow constantly this is the prokaryotic life and.

This is what's in the gut flora.

Practically. These bacteria, they use deuterium.

They do us a great, a great.

Favor simply because they filter out deuterium from our food. But for that, you know, in the.

Meantime, they keep growing constantly.

And that's how stool becomes homies. I'm just, you know, I'm a doctor in that sense. I want to explain this so you understand.

So stool looks pretty much similar of like, you know, it's not really dependent.

What or how much you eat primarily. It's just practically bacteria and high deuterium food products.

Yet low deuterium fatty acids and triglycerides and so on.

After digesting enzyme activities, they actually get, you know, absorbed in our circulation. And low deuterium food usually, or ketogenic diets usually deplete, decrease the bacteria amounts and so that it is less of stool production. But with high fructose, high glucose, high deuterium foods carbohydrate, and flour and bread and, and grains so on, you can actually increase or fibers, you can actually.

Increase.

The number of bacteria in your gut.

But those are prokaryotes.

So they retain deuterium to grow constantly.

Doing us a great favor to the eukaryote cells, which have actually mitochondria that.

Can deplete deuterium in water.

And their DNA is less contaminated with.

Deuteum and so that they can actually wrap it up in a cell nucleus, meaning that those DNA particles, compartments can rest for a while while the cytoplasma or the cell is differentiating or delivering some more sophisticated functions and more precise and more transfer.

We call them differentiation.

When cells become more and more precise in their function instead of dividing constantly like bacteria do.

This is a big difference between prokaryote and eukaryote cells that eukaryotes because they can control their deuterium with the help.

Of prokaryotes in that sense, which actually absorb deuterium or process deuterium in the gut.

And this is why your podcast is.

So interesting, because we are just learning this new function of deuteum on gut flora. And I think this will be very critical in understanding what the gut flora does after all, for us.

But it seems that, you know, deuteum explains the two major cellular phenotypes as.

Far as far as prokaryotes, just like bacteria and eukaryotes, just like human, like liver cells do, practically the size of their DNA is different. And for that reason they can specialize if they are less Saturated with deuterium.

And this role, this very important, you know, kind of switching or splitting duties is between the gut flora and the.

Rest of our body. Practically the gut flora will normalize or try to process deuterium in the gut before it gets absorbed.

And obviously, if there's too much in.

Food, if there's too much in, there's.

Too much luteum in the crops that.

We eat or in the food that we consume or the routines that we elaborate around healthy eating or eating in general. Deuterium, after all, would be just too much for the bacterial gut flora to deplete it completely.

So our body can be more and.

More saturated with the disease processes appearing in that metabolic or degenerative or cellular proliferative or.

Or even our human cells can become bacterial or prokaryote phenotype in that sense.

That they accumulate between them and start going in an uncontrolled fashion. Form of cancer, for example.

Sure. Now we're pretty much coming up to time. Dr. Laszlo, there's just a couple more questions that I'd really like to get through. And firstly, is there a level of deuterium where it could be damaging to prokaryotes?

Prokaryotes, we don't know necessarily how far they can go as like very high deuterium concentrations. We believe that anything above 165,170ppm is very damaging to eukaryote SARS. But for prokaryotes, I don't think there is a. There's an upper limit yet. They actually waste the tune back into the soil or back into the environment.

Simply because they are not stable life forms. So rapid growth is always followed by rapid death.

So usually bacterial cultures or yeast are famous of making things rotten or producing.

Pus or, you know, after all, dismantling.

Themselves because of the high deuterium saturation. With low deuterium contents, we know below 40 ppm, like nothing would grow. Even prokaryotes slow down significantly.

Their growth rates and the lower limits are much more kind of precisely defined.

Than the high range, especially when it comes to prokaryotes.

But this is definitely a very important biological information of how we distribute deuterium among different cellular forms and cellular types and how we split the duty of controlling, you know, deuterium content in our.

Cells deplete as much as possible when.

It comes to mitochondrial functions.

And the full understanding of these systems.

Go through, start from knowing these very basic life forms, prokaryotes and eukaryotes, and it seems that it works very well. For it have it has worked very well for biology, biology for a long time. And the future is questionable simply because we have now epidemiological population scale disease processes, which we believe after all, would be much better handled once deuterium biochemistry or deuterium physiology or deuterium based medicine is taking roles.

Absolutely. And there's a couple of, I guess, additional strategies I'd like to explore in terms of deuterium depletion Breathing. Now, how does breathing affect deuterium?

So by breathing you carry oxygen to your tissues and your breath is deuterium.

Depleted in the first place.

So humans in, by gathering and breathing fume or their own vapor, depletes deuterium. After all, simply because human breath, if it's a healthy individual, it's probably in.

The range of 140, 135ppm. And simply because our metabolic water, which.

Come from our tissue and being exhaled.

Through breath, through breathing, is lower in deuterium, as we, as we mentioned.

So this is measurable, so this is.

Easy to measure these biological principles.

And by breathing, by decreasing oxygen tension somewhat can actually dilate your vessels. And as a result of that, there.

Is more efficient.

Oxygen delivery, especially when.

There'S increasing carbon that dioxide partial pressure.

So breathing controls metabolic water production through dissolved oxygen in your plasma, oxygen that.

Is bound to hemoglobin and carried to cells to the mitochondria, and also by carbon dioxide, which is released as a result of biological substrate oxidation.

And these factors, they all control metabolic water production with some very important hormones.

Like adh, which is an antidiuretic hormone that retains water in our cells or in our body if we don't dilute it, if we don't drink external water, too much external water, especially when we are not thirsty, it's really useless to drink so much water. Breathing is much more important. And light is very important because light, especially red light, can.

Resonate the oxygen.

Hydrogen and carbon hydrogen bonds. Red light makes water more viscous, easier to flow. In our mitochondria.

Mitochondria has this surface or tension water.

That has to be controlled by its viscosity to regulate cellular functions. And red light actually helps our cells, our mitochondria, and also carbon hydrogen resonance in the form of cholesterol and fat.

Fatty acid free fatty acid molecules or.

Triglycerides are also very important to kind of resonate with light and communicate energy with our cells through these hydrogen bonds. And deuterium compromises these functions of both light, oxygen and carbon dioxide.

For that reason, this is just an.

Additional physiological level that hydrogen deuterium physiology comes very handy. Deuterium does not resonate efficiently. Deuterium does not absorb the energy of light. So this is why deuterium depletion is also important. And also breathing is very important. Light and breathing are very important to maintain health.

Absolutely fascinating. I think just one final loop. Now you mentioned light. Now with light and something that we were discussing earlier with light and sleep and melatonin. Now how are these three individual components involved in deuterium depletion?

Yeah, so it seems that sleep is practically a deuterium depleting process. During burning fat at night, using mitochondria, melatonin is released in dark, just in lay terms. So light exposure usually decreases melatonin release. Yet when it gets dark, our melatonin.

Gets high and it accumulates in mitochondria and peroxisomes.

And for that reason when you fall asleep, then you very quickly use up.

Your glucose in your circulation.

If you were awake, you would be hungry and you would eat. But make sure took care of this. So you actually felt unconscious while you're sleeping.

So you don't feel your hunger.

So you allow your body and your melatonin to oxidize fat, low deuterium fat.

To produce metabolic water during night's sleep to deplete your deuterium that you accumulated when you were awake.

So for that reason it seems that the light cycle regulates this deuterium depletion process.

Simply using hormones that activate in our mitochondria and our peroxisomes, water producing enzymes or water producing biochemical architecture or a number of enzymatic steps. After all, in the morning time when we wake up, we have less gluten in our circulation. We have burned fat during night sleep efficiently in peroxisomes, which is low deuterium, which results in low deuterium metabolic water. So we are ready to go again until in the light cycle until it gets dark again and we start the process all over.

Wow, that's absolutely fascinating. We'll link to I guess the article that you sent me earlier today about the, the, I guess the impact of light on melatonin and potential links to breast cancer. Do you want to talk very quickly about that?

Yeah. So Endocrinology 2019, the conference features a talk this year from the University of.

New Orleans Medical School.

And it shows that actually if there.

Is light during sleep, many people like just to leave lights on actually compromises melatonin secretion. And the result of that in a cancer model, scientists were able to show that breast cancer injected in mice metastasizes through the bones much more rapidly when there is light in the cycle and continuous light exposure even at night, night at very low, dim or very low light sources is present. The behavior, the biological behavior of breast cancer in this animal model would dramatically change.

And I would encourage people to look.

At the Endocrinology 2019 news releases because.

This information is so linking light and melatonin with cancer progression through bone metastasis and also adding deuterium and understanding of.

How the system work from our side. Listening to this podcast, which is an.

Honor to me, would explain how and.

Why this model turned out to be a light related cancer propagating cancer growth promoting process.

Yet if we follow the natural light.

Patterns, meaning that we sleep in dark and allow our melatonin to hit high concentrations in our mitochondria and liposomes, then.

We may need less time to sleep.

We are rested, more rested when we wake up and we depleted more due to more efficiently. So we preserved our health during these very interconnected, very fundamental biological processes. And this is what is demonstrated in this abstract. And it's absolutely a fascinating study to linking light, melatonin and cancer growth. And I'm very happy we were able to add our biochemical interpretations to this. And obviously with the help of your podcast too, explain this to some very kind audience and people who are interested in the topic.

Sure. And we'll definitely link to the article in the show notes. And just one final question. Deuterium depleted water. Now I think you kind of started to talk about the process of removing, mechanically removing deuterium or there's some sort of chemical process to remove deuterium from water and get it down to around 25 ppm. Now, in what situation would people be needing to I guess use a type of water that's I guess that depleted?

Yeah. So my advice or my like teaching curriculum is focused on water simply for its deuterium content. And this is a very good question simply because this relates to how much water we should drink and when we should drink water. In healthy individuals usually, and this is.

What I recommend to drink when you are thirsty and wait a little bit.

And you're still thirsty because antidiuretic hormone.

Is very important in many physiological processes.

So for healthy individuals drinking rainwater to.

That matter, which is somewhat deuterium depleted or drinking deuterium depleted water around that or somewhere in the surroundings of 120ppm or below, that's desirable.

If somebody has a disease, for example.

Cancer, diabetes, or has obesity and they.

Want quick start on deuterium depletion, then.

We recommend them or we suggest to learn about how lower deuterium content, like 85 ppm or even 50 or 40 ppm deuterium depleted water may get them on a quick start and start depleting deuterium very quickly to slow down cancer growth, for example, or maybe get the glucose or metabolism in a better shape, glucose status.

So we use this ketogenic diet, deuterium.

Depleting ketogenic diet now, to even treat type 1 diabetes. So it has a dramatic effect on the American Pediatrics Associated Association. Just the paper. The journal of the American Pediatrics association called Pediatrics, just published a paper treating type 1 diabetes successfully using ketogenic diets. And my colleagues in Hungary, Dr. Chabotot and Jophia Clements, you may want to talk to them sometime in the future. But definitely they use ketogenic natural diets, lodithium chemicals, ketogenic diets, they call them paralytic or evolutionary medicine to treat a number of disease conditions. And they are clinicians, they can elaborate and they publish in the field. So there are case reports which show the beneficial effects of deuterium depletion, but as you said, mostly cello proof proliferated like cancer diseases and also metabolic diseases like obesity and the metabolic syndrome. They all benefit from a ketogenic low deuterium ketogenic diet and also consuming luteum depleted water in like low ranges like 85 to like 40 ppm.

Sure. And Dr. Laszlo, just because most of our audience are going to be Australian, we do get a lot of US listeners as well, but particularly for Australian audiences. Now, our deuterium level in our drinking water, in our rainwater, I would say is on a higher end of the scale. So if seawater was 155, our drinking water is 153ppm. So what's, what's your take on that?

Yeah, be honest with you.

It's not appropriate for human consumption. Wow.

You know, that's just. You are in a very dangerous zone in that.

Yeah, absolutely.

So what Australia should do is eat.

More beef, more pork fat, or more.

Like meat that is high in fat.

And produce their own water in their mitochondria instead of drinking water like bottled water that is sold in stores and wait till they get thirsty and don't drink just because somebody told them to drink based on, you know, economically motivated suggestions.

You should, I think biochemically you should learn again.

We are a teaching facility. I teach biochemistry of deuterium so my.

Recommendation is to produce your own water.

When you trust, don't trust or can't trust your external water, your mitochondria are perfect to produce the optimal amount of the best deuterium depleted water for your physiological and biochemical reactions and health to that matter.

And for that reason it's just stay.

Away from, from water, bottled water that is very high. I think that's a fair statement.

You should learn about this by exploring.

Additional information what you hear in this podcast. I'm just covering the very basics but practically like in, in the ballpark range, you should not drink water even when you're thirsty. Anything above like hundred, like 35 ppm, which is rainwater and that's practically the cleanest and that's the lowest team as far as external water goes because that's fractionated.

And Australia, unfortunately, because the island is.

In the middle of the Pacific, middle of the, in, in the ocean. It's, it's, it's, it's you. Your external water will be through the vapor and the evaporation. It will be high in deuterium. Unless there are high elevations in Australia, which I don't think.

Do you guys have big mountains?

We do have mountains, but certainly not like in Europe. And you've got these in other regions where you've got the glacial type waters. Our water from what we've tested.

Yeah, yeah. About this problem in Australia. So just keep eating and keep producing your own water. I think that's the safest.

Yeah. And what we'll do is we'll certainly link to the deuterium depletion center as well, which you're part of because I think it's an amazing resource and particularly for people in Australia and in New Zealand and island type nations that have the luxury of having rainwater at 135. We need help. I mean you can see it in the rates of cancers and obesity and illness in Australia. We need your help, Dr. Barash. So I'll definitely be linking to your website. Yeah.

Thank you so much yet again. One of our colleagues, Dr. Cooper, is from Australia and she is now definitely.

One of the experts clinicians in deuterium depletion. We are very happy to help or study this question or this problem further with our Australian friends and colleagues. We are there for you guys anytime you need us and I hope we.

Can give you some very useful and.

Beneficial advice based on biochemistry teaching and you can actually go after this information by yourself. As we point to the source of.

Literature or published studies that we use.

For our own interpretations. We definitely have studied this for over a longer period of time and we teach this accordingly. And hopefully this type of information will be helpful to our friends and our colleagues in Australia.

Absolutely. And Dr. Laszlo, one final question before we start to wrap. If there was one thing that you would recommend for our audience to improve their health, it could be gut health, mitochondrial health, any health. What would be your top tip?

It's practically listen to your own body as far as hunger and thirst and.

What to desire to eat.

With the knowledge of how to sense deuterium in the environment, animals can differentiate.

Among water that high enduteum.

Now we also can as we have studied. It was funny because I was in China and they gave us blindly water.

With deuterium depletion, I think 105 tap water and 50 ppm. And we picked them up correctly several times. Blindly mixing.

Because you have to learn. I think humans lost their ability to kind of sense viscosity of water or acidity of water that is controlled by protons and deuterium. But you can learn this very quick and you can actually guide yourself in your environment.

What you should or what you shouldn't drink.

We can't really by taste or by smoothness of water. You can actually learn how to differentiate.

Among water sources with different deuterium concentrations.

Again, you have to learn about this.

Process and you have to kind of live with it or have to kind of live a lifestyle. Is more like deuterium conscious yet you know, I think after all, if you.

Eat what you desire, it's mostly ketogenic.

Like fat and meat based with some vegetable and some greens that are also grown naturally, you know, excluding industrial food processes or processed food. And you drink water when you're thirsty and you also drink as much as.

You need to cure your thirst without.

Supplements because those are really not necessary unless you know you are in a you need it medically unless you're deficient. The best way to handle your mitochondrial health is to be exposed to light.

As much as possible in your local growths and local environments.

To consume food that is local, mostly fat based, mostly ketogenic, and drink very little if necessary water and allow your body to produce its own water and retain its own own water by the combination of antidiuretic hormone, light exposure, melatonin. Sleep good, sleep in the dark, not to be exposed to electromagnetic waves including lead and so on.

Everything that Dr. Jack Cruz and Dr.

Gabor Shomiyai were mentioning with my biochemistry background and teaching are very important after all to maintain your health in a good state. And obviously this is the main goal of our activities at the centers to team depletion, to bring this knowledge and some experience to people.

Wow. Amazing. And what a beautiful way to finish the podcast. I just want to thank you for bringing this revolutionary information to our audience here in Australia and across the world. Thank you so much Dr. Laszlo Borosh.

Thank you.

And if you have questions or you want to follow up, if you connect with our centers, then you can explore this further for your pattern and good life. Thank you so much.

Wonderful. Thank you. Dr. Leslie hey guys.

We hope you enjoyed this episode of the Gut Health Gurus podcast with Dr. Laszlo Borush. You can find show notes and links@www.podcast.nourishmeorganics.com au. If you enjoyed this podcast, please give us a positive review at 5 stars on iTunes and share our podcast with your friends and family members. If you're interested in learning more about deuterium depleted water, head to www.nourishmeorganics.com and search for preventer that's P R e v e n t a preventer.