The speaker explains how insulin resistance interferes with the release of brain hormones, which then disrupts the timing of ovulation and throws ovarian hormone levels out of balance. This hormonal imbalance further worsens insulin resistance, creating a self‑reinforcing loop that perpetuates PCOS. The key message is that this vicious cycle must be interrupted in order to effectively treat PCOS.
Insulin resistance negatively affects the proper release of the brain hormones. Now, when ovulation doesn't occur on time, the downward hormonal balance— the hormones which have to come from the ovaries, they also go off balance. Now, this creates a domino effect. So insulin resistance causing hormonal imbalance, and hormonal imbalance causing insulin resistance, and the insulin resistance causing further hormonal imbalance. So you see, it becomes a loop, a cycle, and we need to break this cycle. We need to out of this cycle to break this PCOS thing.
