#351: Unlocking The Secret To Age Reversal with Carolina Oliveira Co-founder & CEO at OneSkin

4 Nov 2025 · 55 min
Episode

4 Nov 2025 · 55 min

0:00

Podcast episode #351 (host Heather Monahan) interviews Carolina Oliveira, PhD, co‑founder & CEO of OneSkin. Carolina recounts moving from Brazil to Silicon Valley (joined IndieBio in 2016), early company pivots (lab-grown skin for testing → product testing → developing a peptide-based longevity skincare product) and the 3–4 year R&D effort to discover a peptide (OS1) that reduces senescent cells. OneSkin’s approach targets cellular senescence rather than surface-level effects (e.g., retinol); lab data cited include testing ~1,000 peptides and a reported ~2.5-year reduction in measured skin biological age over five days in vitro. The brand launched commercially in 2021 and offers a concise line (face moisturizer, body moisturizer, cleanser, eye product; sunscreen forthcoming), refillable packaging and subscription options (30/60/90 days). Clinical endpoints are measured at 6 and 12 weeks; consumer anecdotes report visible changes as early as 2–4 weeks for texture/hydration and up to ~3 months for collagen-related changes. Carolina emphasizes safety, gender‑neutral branding (~30% of customers are male), sustainability, and combining OneSkin with retinol on alternating days if desired.

Questions this episode answers

Around 2014.

2016.

Nearly 1,000 peptides.

A reported ~2.5-year reduction in measured skin biological age over five days in lab-grown skin (in vitro).

About three to four years of research to identify the main peptide.

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